Results 231 to 240 of about 25,845 (281)
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Drug Metabolism and Disposition, 2012
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
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Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
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Synthesis of the glucuronide of Carazolol
Carbohydrate Research, 1988AbstractRacemic carazolol (Ia) is converted into its N‐protected derivative (Ib) by treatment with di‐tert‐butyl carbonate (II).
Hans Steinhart +2 more
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Drug glucuronidation in humans
Pharmacology & Therapeutics, 1991Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-glucuronosyltransferase family. It is believed that a number (unspecified at present) of glucuronosyltransferase isozymes, which probably differ in terms of substrate ...
Peter I. Mackenzie, John O. Miners
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Glucuronidation and its impact on the bioactivity of [6]-shogaol.
Molecular Nutrition & Food Research, 2017SCOPE -shogaol (6S) from ginger has been reported to have diverse bioactivities and can be widely metabolized in animals and humans; however, the impact of glucuronidation on its bioactivity is still largely unknown.
Pei Wang +3 more
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On the formation of carbamate glucuronides
Xenobiotica, 1990(1990). On the formation of carbamate glucuronides. Xenobiotica: Vol. 20, No. 1, pp. 133-134.
L. P. C. Delbressine +3 more
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Acta Pharmacologica et Toxicologica, 1978
Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
Bo Andersson +3 more
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Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
Bo Andersson +3 more
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Current Drug Metabolism, 2011
This review on isomers or acyl glucuronides (iso-glucuronides) updates earlier reviews, and attempts to place in context the advances that have been made, especially over the last 15 years. The essential chemistry behind the intramolecular acyl migration and anomerization reactions of acyl glucuronides has been appreciated for 30 years.
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This review on isomers or acyl glucuronides (iso-glucuronides) updates earlier reviews, and attempts to place in context the advances that have been made, especially over the last 15 years. The essential chemistry behind the intramolecular acyl migration and anomerization reactions of acyl glucuronides has been appreciated for 30 years.
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Molecular Pharmaceutics, 2015
Efflux of glucuronide is facilitated by the membrane transporters including BCRP and MRPs. In this study, we aimed to determine the effects of transporter expression on glucuronide efflux and cellular glucuronidation.
Xingwang Zhang +5 more
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Efflux of glucuronide is facilitated by the membrane transporters including BCRP and MRPs. In this study, we aimed to determine the effects of transporter expression on glucuronide efflux and cellular glucuronidation.
Xingwang Zhang +5 more
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MicrosomalAcyl Glucuronidation: Enzyme-Kinetic Studies with Labile Glucuronides
Pharmacology, 1993Because of the labile nature of acyl glucuronides under physiologic conditions, metabolic rates of formation calculated using traditional methods may be confounded by concomitant rates of degradation. True metabolic formation rates may be approximated by stabilization of the metabolic product or by purifying the metabolite and calculating its ...
Leslie Z. Benet +1 more
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Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide
Applied Radiation and Isotopes, 2007A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate.
Unak, P. +5 more
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