Results 241 to 250 of about 25,845 (281)

The Effect of Chloroform Inhalation on Hepatic Glucuronidation and De-Glucuronidation Mechanisms

Drug and Chemical Toxicology, 1980
The effect of 2, 4, 6 or 8 exposures to chloroform vapour on hepatic glucuronidating (UDPGA transferase) and de-glucuronidating (beta-glucuronidase) levels has been studied in rats. Successive treatments progressively decreased hepatic UDPGA transferase to a minimum of 53% of the control level.
H M Dorrell, D.C. Williams, M. Jenner, Ifor D. Capel   +3 more
openaire   +3 more sources

The synthesis of O-glucuronides

Natural Product Reports, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Andrew V. Stachulski, Gareth V. Jenkins
openaire   +4 more sources

Decreased Expression of Multidrug Resistance-Associated Protein 4 (MRP4/ABCC4) Leads to Reduced Glucuronidation of Flavonoids in UGT1A1-Overexpressing HeLa Cells: The Role of Futile Recycling.

Journal of Agricultural and Food Chemistry, 2015
In this study, the role of futile recycling (or deglucuronidation) in the disposition of two flavonoids (i.e., genistein and apigenin) was explored using UGT1A1-overexpressing HeLa cells (or HeLa1A1 cells).
Hua Sun, Xiaotong Zhou, Xingwang Zhang, Baojian Wu   +3 more
semanticscholar   +1 more source

The mechanism of glucuronide formation

Biochemical Pharmacology, 1961
Abstract The mechanism of formation of simple glucuronides in animal tissues is reviewed. So far glucuronide synthesis has been found to occur in liver and to a lesser extent in kidney of a number of animal species. Of the mammals studied cat liver slices formed very little glucuronide. More recently glucuronide formation has been discovered to occur
openaire   +3 more sources

GLUCURONIDATION OF HMR1098 IN HUMAN MICROSOMES: EVIDENCE FOR THE INVOLVEMENT OF UGT1A1 IN THE FORMATION OF S-GLUCURONIDES

Drug Metabolism and Disposition, 2003
HMR1098, a novel KATP-blocking agent, is metabolized to form an S-glucuronide in rat and dog bile. Synthesis of the S-glucuronide metabolite was studied in human liver and kidney microsomes. Recombinant UPD-glucuronosyltransferases (UGTs) were screened for activity, and kinetic analysis was performed to identify the isoform or isoforms responsible for ...
Herbert Jantz, Heinrich Englert, Jens Riedel, Brian Burchell, Brian T. Ethell, Raymond Oekonomopulos   +5 more
openaire   +3 more sources

Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo

Archives of Toxicology, 2020
Icaritin (ICT), a prenylflavonoid derivative extracted from the Epimedium genus, has exhibited antitumor effects in hepatocellular carcinoma (HCC) cells and safety and tolerance in clinical settings. However, ICT exhibits low blood concentration and the in vivo dominant plasma species of ICT is glucuronides [icaritin-3-glucuronide (G1), icaritin-7 ...
Yi Rong, Yifan Tu, Taijun Yin, Zhiyun Meng, Guifang Dou, Ming Hu   +5 more
openaire   +3 more sources

Modulation of metabolic effects of morphine-6-glucuronide by morphine-3-glucuronide

Brain Research Bulletin, 1995
Modification of pharmacological effects of morphine by its glucuronides has been recently reported. Morphine-6-glucuronide (M6G) is a more potent opioid agonist than morphine, whereas morphine-3-glucuronide (M3G) has no opioid effects and has been suggested to be an antagonist of morphine's antinociceptive and respiratory depressive effects. This study
Naji N. Abumrad, Yojiro Hashiguchi, Patricia E. Molina   +2 more
openaire   +2 more sources

Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9.

Journal of Pharmacy and Science, 2015
In this study, we aimed to determine the glucuronidation potential of psoralidin in humans and to perform validation on use of psoralidin-3-O-glucuronidation as a functional marker for UGT1A9.
Hua Sun, Zhiguo Ma, Danyi Lu, Baojian Wu
semanticscholar   +1 more source

Rapid glucuronidation of tri- and tetraiodothyroacetic acid to ester glucuronides in human liver and to ether glucuronides in rat liver.

Endocrinology, 1994
T3 is the principal bioactive thyroid hormone, although its metabolite 3,3',5-triiodothyroacetic acid (TA3) shows higher affinity for the nuclear T3 receptor. However, TA3 has a low in vivo potency because of its short half-life in both humans and rats.
Maria Moreno, Ellen Kaptein, Fernando Goglia, Theo J. Visser   +3 more
openaire   +3 more sources

Sex differences in the excretion of glucuronide conjugates: the role of intrarenal glucuronidation.

The Journal of Pharmacology and Experimental Therapeutics, 1983
Female Fischer 344 rats administered p-nitrophenol (0.05 mmol/kg) excrete more p-nitrophenylglucuronide in the urine than males (35.9 +/- 2.9 vs. 14.1 +/- 4.0% of total urinary metabolites, respectively). In contrast, hepatic microsomes prepared from male rats have higher UDP-glucuronyltransferase activity toward p-nitrophenol than hepatic microsomes ...
G F, Rush, J F, Newton, J B, Hook
openaire   +2 more sources