Results 251 to 260 of about 25,845 (281)

Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice

European Journal of Pain, 1997
Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C., Olaso, M. Jesús, Horga, José F.   +2 more
openaire   +4 more sources

ChemInform Abstract: An Estrone‐Glucuronide Conjugate.

ChemInform, 1997
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Joyce M. Waters, Christopher Mark Smales, Anthony K. Burrell, Leonard F. Blackwell   +3 more
openaire   +3 more sources

Preparation of specific antisera to estrone-3-glucuronide and estriol-3-glucuronide

Journal of Steroid Biochemistry, 1984
The preparation and antigenic properties of estrone-3-glucuronide- and estriol-3-glucuronide-bovine serum albumin conjugates in which the hapten is linked to the carrier protein through an (O-carboxymethyl)oxime bridge at the C-6 position on the steroid nucleus, have been described.
Nambara Toshio, Shimada Kazutake, Yamaki Teruko, Ohkubo Tadashi   +3 more
openaire   +3 more sources

Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism?

Drug Metabolism Reviews, 1992
(1992). Acyl Glucuronides Revisited: Is the Glucuronidation Proces a Toxification as Well as a Detoxification Mechanism? Drug Metabolism Reviews: Vol. 24, No. 1, pp. 5-47.
Leslie Z. Benet, Hildegard Spahn-Langguth   +1 more
openaire   +3 more sources

The Effect of Raltegravir on the Glucuronidation of Lamotrigine

The Journal of Clinical Pharmacology, 2009
The authors studied the effect of raltegravir on the pharmacokinetics of the antiepileptic agent lamotrigine. Twelve healthy volunteers (group A) received 400 mg raltegravir twice daily from days 1 to 5. On day 4, a single dose of 100 mg lamotrigine was administered.
Luin, M. van, Colbers, A., Verwey-van Wissen, C.P.W.G.M., Ewijk-Beneken Kolmer, E.W.J. van, Kolk, M. van der, Hoitsma, A.J., Silva, H.G. da, Burger, D.M.   +7 more
openaire   +4 more sources

Identification and characterization of human UDP-glucuronosyltransferases responsible for the glucuronidation of fraxetin.

Drug Metabolism and Pharmacokinetics, 2014
Fraxetin, a major constituent of the traditional medicine plant Fraxinus rhynchophylla Hance (Oleaceae), has been found to possess multiple bioactivities. However, the metabolic pathway(s) of fraxetin in human tissues has not been reported yet.
Yang-Liu Xia, S. Liang, Liangliang Zhu, Guangbo Ge, G. He, Jing Ning, X. Lv, Xiaochi Ma, Ling Yang, Sheng-Li Yang   +9 more
semanticscholar   +1 more source

Human liver glucuronidation of benzidine

Carcinogenesis, 1994
Although glucuronidation is considered an important pathway in aromatic amine-induced bladder cancer, benzidine glucuronidation has not been assessed in humans. Glucuronidation of benzidine was assessed with human liver microsomes and slices. Emulgen 911-treated microsomes exhibited a Km for benzidine of 0.8 +/- 0.06 mM and a Vmax of 4.2 +/- 0.7 nmol ...
Ida S. Owens, Satram R. Babu, Terry V. Zenser, Bernard B. Davis, Vijaya M. Lakshmi   +4 more
openaire   +3 more sources

Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes

Xenobiotica; the fate of foreign compounds in biological systems, 2018
Li Wang, X. Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, F. Gonzalez, X. Yao   +8 more
semanticscholar   +1 more source

19. EFFECT OF GLUCURONIDES ON THE GLUCURONIDE BIOSYNTHESIS

Acta Paediatrica, 1970
J. Marniemi, O. Hänninen
openaire   +2 more sources

Glucuronidation of Drugs and Other Compounds

, 2019
G. Dutton
semanticscholar   +1 more source