Results 141 to 150 of about 30,656 (311)

A comprehensive review of UDP-glucuronosyltransferase and esterases for drug development.

Drug Metabolism and Pharmacokinetics, 2015
Shingo Oda, T. Fukami, T. Yokoi, M. Nakajima   +3 more
semanticscholar   +1 more source

Gilbert Syndrome and the Development of Antiretroviral Therapy-Associated Hyperbilirubinemia [PDF]

, 2017
BackgroundUnconjugated hyperbilirubinemia results from Gilbert syndrome and from antiretroviral therapy (ART) containing protease inhibitors. An understanding of the interaction between genetic predisposition and ART may help to identify individuals at ...
Bernasconi, Enos, Bleiber, Gabriela, Drechsler, Henning, Furrer, Hansjakob, Günthard, Huldrych F., Rickenbach, Martin, Rotger, Margalida, Taffé, Patrick, Telenti, Amalio, Vernazza, Pietro   +9 more
core  

Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver.

, 1986
Erin G. Schuetz, G A Hazelton, Judith G. Hall, P B Watkins, Curtis D. Klaassen, Philip S. Guzelian   +5 more
openalex   +1 more source

Regulation and function of family 1 and family 2 UDP-glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus [PDF]

, 1999
Christian P. Strassburg, Ahlke Strassburg, Nghia Nguyen, Qing Li, Michael P. Manns, Robert H. Tukey   +5 more
openalex   +1 more source

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance

AAPS Journal, 2016
U. Argikar, Philip M. Potter, J. Hutzler, Punit H. Marathe   +3 more
semanticscholar   +1 more source

SAFETY EVALUATION OF STATIN IN YOGYAKARTA, INDONESIA [PDF]

, 2009
Background : The 3-hydroxy-3-methylglutaryl-coenzyme (HMG-Co-A) reductase inhibitors, also known as statins, are the most effective class of drugs for lowering serum Low-Density Lipoprotein cholesterol (LDL-c)concentrations.
Anni, Anni, Labado, R.O., Perwitasari, Dyah Aryani, Udu, W.S.A.   +3 more
core  

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders[S]

Journal of Lipid Research, 2013
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones.
Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W. Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J. Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun   +14 more
doaj  

The enzymatic mechanism of glucuronidation catalyzed by two purified rat liver steroid UDP-glucuronosyltransferases.

, 1987
Charles N. Falany, M D Green, Thomas R. Tephly   +2 more
openalex   +1 more source

Xenobiotic Responsive Element-mediated Transcriptional Activation in the UDP-glucuronosyltransferase Family 1 Gene Complex [PDF]

, 1996
Yoshikazu Emi, Shinichi Ikushiro, Takashi Iyanagi   +2 more
openalex   +1 more source

Developmental alterations in hepatic UDP-glucuronosyltransferase

, 1986
Laurene H. Wang, David Zakim, Abraham M. Rudolph, Leslie Z. Benet   +3 more
openalex   +1 more source