Results 161 to 170 of about 7,364 (182)

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia

Psychiatric Genetics, 2009
As dysfunction of glutamatergic neurotransmission is one of the plausible hypotheses for the pathogenesis of schizophrenia, genes involved in the glutamate neurotransmitter system are candidates for schizophrenia susceptibility. The aim of this study is to clarify the contribution of two genes encoding glutamate metabolic enzymes: the glutamic acid ...
Shinsaku, Arai, Hiroki, Shibata, Mayumi, Sakai, Hideaki, Ninomiya, Nakao, Iwata, Norio, Ozaki, Yasuyuki, Fukumaki   +6 more
openaire   +2 more sources

m6A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression

Journal of Hazardous Materials
Hexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI).
Jing-Hua Yang, Ming-Liang He, Jian-Ge Qiu   +2 more
exaly   +3 more sources

GLUL drives metabolic reprogramming and confers docetaxel resistance in prostate cancer

Biochemical Pharmacology
Docetaxel is a first-line chemotherapeutic agent for advanced and castration-resistant prostate cancer (CRPC), yet acquired resistance limits its long-term efficacy. Metabolic reprogramming has emerged as a central mechanism of therapeutic resistance; however, the metabolic determinants of docetaxel resistance remain incompletely defined.Here, we ...
Zihang Wu, Xiangwei Wang, Ran Xu, Yuqi wu, Qiuxia Ding, Wei Huang, Yuanfei Huang, Ying Zhang   +7 more
openaire   +1 more source

Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation

Experimental Eye Research
Idiopathic epiretinal membrane (iERM) represents a fibrocellular proliferation on retinal surface associated with vision loss, with underlying molecular mechanisms that remain undefined. The current work aimed to assess miR-127-5p for its role in the regulation of retinal Müller cell activity in iERM.
Danxue He, Jian Zou, Quanyong Yi
exaly   +3 more sources

Abstract P4-06-10: Epigenetic silencing of glutamine synthetase (Glul) defines glutamine depletion therapy

Cancer Research, 2012
Abstract Background: Methylation-dependent transcriptional silencing of genes involved in amino acid synthesis can provide potential targets for novel synthetic lethality strategies. Glutamine synthetase (Glul) is the key enzyme in the biosynthesis of glutamine.
F Cavicchioli, A Shia, K O'Leary, V Haley, TR Crook, AM Thompson, M Lackner, Nigro C Lo, P Schmid   +8 more
openaire   +1 more source

Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase

American Journal of Human Genetics
Glutamine synthetase (GS), encoded by GLUL, catalyzes the conversion of glutamate to glutamine. GS is pivotal for the generation of the neurotransmitters glutamate and gamma-aminobutyric acid and is the primary mechanism of ammonia detoxification in the brain.
Amy G Jones, Laura Duncan, Gemma L Carvill   +2 more
exaly   +4 more sources

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL

Gut
Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular ...
Mi Zhang, Chanyuan Chen, Haifeng Zhang, Tanqing Long, Tingjie Wang, Nanjin Ding, Ruitao Long, Hua Wu, Zhilu Ma, Zhongyu Cheng, Junyan Tao, Dong Kuang, Lei Li, Chuanrui Xu   +13 more
openaire   +2 more sources

Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis

Biochimica Et Biophysica Acta - Molecular Basis of Disease
The 5-year survival for non-small cell lung cancer (NSCLC) remains
Shuaini Yang
exaly   +3 more sources

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes

Journal of Molecular Neuroscience, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D).
Griffin, Jeddidiah W.D., Liu, Ying, Bradshaw, Patrick C., Wang, Kesheng   +3 more
openaire   +3 more sources

Assignment of the porcine GLUL gene to the distal end of chromosome 9q

Animal Genetics, 2002
A, Stratil, S, Kubícková, A L, Archibald, L J, Peelman, M, McClenaghan, P, Musilová, M, Van Poucke, J, Rubes   +7 more
openaire   +2 more sources