Results 151 to 160 of about 7,364 (182)
Neuro-Transcriptomic Responses to Polypharmacological Agents in <i>Danio rerio</i>: Implications for Translational Drug Repurposing in Neurodevelopmental Disorders. [PDF]
Brain SciBartkowiak AD, Mooney MR.
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High-concentration peat drives divergent transcriptomic responses to enhance saline-alkaline tolerance and phytoremediation in two <i>Suaeda</i> species. [PDF]
Front Plant SciZhou L, Du Z, Lv P, Wang Z, Cai C, Li J.
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GLUL Promotes Cell Proliferation in Breast Cancer
Journal of Cellular Biochemistry, 2017Glutamate-ammonia ligase (GLUL) belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. Here, we found higher expression of GLUL in the breast cancer patients was associated with larger tumor size and higher level of HER2 expression.
Shaohua Fan, Jun Lu, Dong-Mei Wu
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PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma
Science Advances, 2023 For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown. By conducting an unbiased CRISPR-Cas9 screening, we identified the epigenetic regulator plant homeodomain ...
Song Peng, Ze Wang, Peng Tang
exaly +3 more sources
GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]
Cancers, 2019 Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the same drugs.
Magesh Muthu +2 more
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Journal of Proteome Research, 2019
Hypoxia as well as metabolism are central hallmarks of cancer, and hypoxia-inducible factors (HIFs) and metabolic effectors are crucial elements in oxygen-compromised tumor environments. Knowledge of changes in the expression of metabolic proteins in response to HIF function could provide mechanistic insights into adaptation to hypoxic stress ...
Stephan Bernhardt +2 more
exaly +4 more sources
Hypoxia as well as metabolism are central hallmarks of cancer, and hypoxia-inducible factors (HIFs) and metabolic effectors are crucial elements in oxygen-compromised tumor environments. Knowledge of changes in the expression of metabolic proteins in response to HIF function could provide mechanistic insights into adaptation to hypoxic stress ...
Stephan Bernhardt +2 more
exaly +4 more sources
Doklady Biochemistry and Biophysics, 2022
The Chinese hamster ovary cell line CHO is widely used for biopharmaceutical production. Genome editing makes it possible to improve the growth properties of cells, their auxotrophy, and the functioning of the apoptosis and autophagy induction systems.
N A, Orlova +5 more
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The Chinese hamster ovary cell line CHO is widely used for biopharmaceutical production. Genome editing makes it possible to improve the growth properties of cells, their auxotrophy, and the functioning of the apoptosis and autophagy induction systems.
N A, Orlova +5 more
openaire +2 more sources
Diabetes, 2023
Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Xiaowen Pan +14 more
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Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Xiaowen Pan +14 more
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2012
The enzyme glutamine synthetase (GS; glutamate-ammonia ligase, EC 6.3.1.2) plays an important role in the nitrogen metabolism of fish. In this study the GS activity and the corresponding genes were examined to understand how they are regulated in zebrafish in response to hyperammonemic stress during a 72 h simulated transport. Whole body ammonia levels,
Anusha K S, Dhanasiri +2 more
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The enzyme glutamine synthetase (GS; glutamate-ammonia ligase, EC 6.3.1.2) plays an important role in the nitrogen metabolism of fish. In this study the GS activity and the corresponding genes were examined to understand how they are regulated in zebrafish in response to hyperammonemic stress during a 72 h simulated transport. Whole body ammonia levels,
Anusha K S, Dhanasiri +2 more
openaire +2 more sources