Results 151 to 160 of about 4,820 (182)

Aspartame may promote erectile dysfunction via DPP4-mediated endothelial dysfunction and apoptosis: evidence from network toxicology, molecular dynamics simulation, and experimental validation. [PDF]

Front Nutr
Dai Z, Wang S, Chen Z, Zhang Q, Wang B.
europepmc   +1 more source

BMAL1 modulates glutamine supply to control haematopoietic stem and progenitor cell expansion. [PDF]

Development
Petzold T, Lutes LK, Navarro i Batista K, Navarro i Batista K, Konle A, Baechler B, Jemelin S, Gerhardt H, Golub R, Scheiermann C, Bertrand JY.   +10 more
europepmc   +1 more source

Metabolomics and Transcriptomics Reveal the Effects of Fermented Lycium barbarum (Goji) Berry Residue on Muscle Nutrition and Flavor Quality in Fattening Tan Sheep. [PDF]

Metabolites
Zhan C, Li M, Li D, Li P, Zhang Q, Wu M, Zhong G, Xu X.   +7 more
europepmc   +1 more source

ABCC2 as a novel therapeutic target in lung adenocarcinoma: a machine learning-driven discovery linking ammonia metabolism to prognosis and drug resistance. [PDF]

J Transl Med
Liao S, Huang Z, Liu X, Wang K, Zheng Z, Li Y, Liu S, Dai Z, Yang M, Jiang L, Dai J, Liu Q.   +11 more
europepmc   +1 more source

The Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk. [PDF]

Cell Mol Gastroenterol Hepatol
Han X, Hou Y, Chen T, Jia Z, Yuan F, Wang M, Su Y, Yan R, Wang X, Jin W, Zhou Y, Li Y, Zhang L.   +12 more
europepmc   +1 more source

Impaired nitrogenous waste clearance promotes hepatocellular carcinoma. [PDF]

Sci Adv
Han X, Shen J, Yan J, Tacke R, Dai W, Mao Q, Queen Daguplo H, Liu S, Islam A, Liu T, Koch MC, Lin RZ, Li H, Anthony T, Xie P, Zhang L, Gao S, Simon MC, Chen X, Yang J, Su X, Zong WX.   +21 more
europepmc   +1 more source

Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency [PDF]

Clinical Genetics, 2020
AbstractGlutamine synthetase (GS) is the enzyme responsible for the biosynthesis of glutamine, providing the only source of endogenous glutamine necessary for several critical metabolic and developmental pathways. GS deficiency, caused by pathogenic variants in the glutamate‐ammonia ligase (GLUL) gene, is a rare autosomal recessive inborn error of ...
Saadet Mercimek-Mahmutoglu, Andreas Schulze, Susan Blaser   +2 more
exaly   +8 more sources

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]

Cancers, 2019
Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the same drugs.
Ranjeet Kumar, Jenny Persson, Ranjeet Kumar   +2 more
exaly   +8 more sources

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes [PDF]

Diabetes, 2015
Single nucleotide polymorphism (SNP) rs10911021 at the glutamate-ammonia ligase (GLUL) locus has been associated with an increased risk of coronary heart disease in individuals with type 2 diabetes. The effect of this SNP on mortality was investigated among 1,242 white subjects with type 2 diabetes from the Joslin Kidney Study (JKS) (n = 416) and the ...
Diego Bailetti, Salvatore de Cosmo, Sabrina Prudente   +2 more
exaly   +6 more sources

Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase [PDF]

American Journal of Human Genetics
Glutamine synthetase (GS), encoded by GLUL, catalyzes the conversion of glutamate to glutamine. GS is pivotal for the generation of the neurotransmitters glutamate and gamma-aminobutyric acid and is the primary mechanism of ammonia detoxification in the brain.
Amy Jones, Stephen Robertson, Muriel Holder-Espinasse   +2 more
exaly   +6 more sources