Results 131 to 140 of about 4,187 (148)

SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL

Gut
Background SIRT6 acts as a tumour suppressor in multiple cancers by regulating glucose and lipid metabolism, but its role in intrahepatic cholangiocarcinoma (ICC) remains unclear. Objective We investigated the role and molecular ...
Mi Zhang, Chanyuan Chen, Haifeng Zhang, Tanqing Long, Tingjie Wang, Nanjin Ding, Ruitao Long, Hua Wu, Zhilu Ma, Zhongyu Cheng, Junyan Tao, Dong Kuang, Lei Li, Chuanrui Xu   +13 more
openaire   +2 more sources

Abstract P4-06-10: Epigenetic silencing of glutamine synthetase (Glul) defines glutamine depletion therapy

Cancer Research, 2012
Abstract Background: Methylation-dependent transcriptional silencing of genes involved in amino acid synthesis can provide potential targets for novel synthetic lethality strategies. Glutamine synthetase (Glul) is the key enzyme in the biosynthesis of glutamine.
F Cavicchioli, A Shia, K O'Leary, V Haley, TR Crook, AM Thompson, M Lackner, Nigro C Lo, P Schmid   +8 more
openaire   +1 more source

Clustered de novo start-loss variants in GLUL result in a developmental and epileptic encephalopathy via stabilization of glutamine synthetase

American Journal of Human Genetics
Glutamine synthetase (GS), encoded by GLUL, catalyzes the conversion of glutamate to glutamine. GS is pivotal for the generation of the neurotransmitters glutamate and gamma-aminobutyric acid and is the primary mechanism of ammonia detoxification in the brain.
Amy Jones, Stephen Robertson, Muriel Holder-Espinasse   +2 more
exaly   +4 more sources

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes

Journal of Molecular Neuroscience, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer's disease (AD), major depressive disorder (MDD), and type 2 diabetes (T2D).
Griffin, Jeddidiah W.D., Liu, Ying, Bradshaw, Patrick C., Wang, Kesheng   +3 more
openaire   +3 more sources

Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis

Biochimica Et Biophysica Acta - Molecular Basis of Disease
The 5-year survival for non-small cell lung cancer (NSCLC) remains
Changsen, Bai, Chaomin, Wang, Jialei, Hua, Na, Zhao, Tong, Li, Wenxin, Li, Wenhao, Niu, Benfu, Zhong, Shuaini, Yang, Chunda, Chen, Gang, Zhao, Li, Qiu, Zhansheng, Jiang, Lifang, Li, Yueguo, Li, Hailong, Wang   +15 more
exaly   +3 more sources

Assignment of the porcine GLUL gene to the distal end of chromosome 9q

Animal Genetics, 2002
A, Stratil, S, Kubícková, A L, Archibald, L J, Peelman, M, McClenaghan, P, Musilová, M, Van Poucke, J, Rubes   +7 more
openaire   +2 more sources

The bovine glutamine synthase gene ( GLUL ) maps to 10q33 and a pseudogene ( GLULP ) to 16q21

Mammalian Genome, 1997
Masabanda J, Wigger G, Eggen A, Stranzinger G, Fries R   +4 more
openaire   +3 more sources

Two Siblings With Valproate-Related Hyperammonemia and Novel Mutations in Glutamine Synthetase (GLUL) Treated With Carglumic Acid

Child Neurology Open, 2020
Jennifer Bennett
exaly  

Homozygous GLUL deletion is embryonically viable and leads to glutamine synthetase deficiency

Clinical Genetics, 2020
Saadet Mercimek-Andrews, Andreas Schulze, Susan Blaser   +2 more
exaly  

Genetic Variant at the GLUL Locus Predicts All-Cause Mortality in Patients With Type 2 Diabetes

Diabetes, 2015
Diego Bailetti, Salvatore De Cosmo, Sabrina Prudente   +2 more
exaly