Results 121 to 130 of about 4,187 (148)

PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma

Science Advances, 2023
For clear cell renal cell carcinoma (ccRCC), lipid deposition plays important roles in the development, metastasis, and drug resistance. However, the molecular mechanisms underlying lipid deposition in ccRCC remain largely unknown. By conducting an unbiased CRISPR-Cas9 screening, we identified the epigenetic regulator plant homeodomain ...
, Yapeng Wang, Dianzheng Zhang
exaly   +3 more sources

GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism [PDF]

Cancers, 2019
Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the same drugs.
Ranjeet Kumar, Jenny Persson, Ranjeet Kumar   +2 more
exaly   +5 more sources

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Functional Proteomics of Breast Cancer Metabolism Identifies GLUL as Responder during Hypoxic Adaptation

Journal of Proteome Research, 2019
Hypoxia as well as metabolism are central hallmarks of cancer, and hypoxia-inducible factors (HIFs) and metabolic effectors are crucial elements in oxygen-compromised tumor environments. Knowledge of changes in the expression of metabolic proteins in response to HIF function could provide mechanistic insights into adaptation to hypoxic stress ...
Clemens Kreutz, Stephan Bernhardt, Christian Tönsing   +2 more
exaly   +4 more sources

Targeted Knockout of the dhfr, glul, bak1, and bax Genes by the Multiplex Genome Editing in CHO Cells

Doklady Biochemistry and Biophysics, 2022
The Chinese hamster ovary cell line CHO is widely used for biopharmaceutical production. Genome editing makes it possible to improve the growth properties of cells, their auxotrophy, and the functioning of the apoptosis and autophagy induction systems.
N A, Orlova, L K, Dayanova, E A, Gayamova, M V, Sinegubova, S V, Kovnir, I I, Vorobiev   +5 more
openaire   +2 more sources

Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming

Diabetes, 2023
Thermogenic adipocytes have been extensively investigated because of their energy-dissipating property and therapeutic potential for obesity and diabetes. Besides serving as fuel sources, accumulating evidence suggests that intermediate metabolites play critical roles in multiple biological processes.
Xiaowen Pan, Lingxia Ye, Xiaozhen Guo, Weihua Wang, Ziyin Zhang, Qintao Wang, Jingjing Huang, Jingya Xu, Yanhan Cai, Xinxin Shou, Yuting Wang, Yu Feng, Cen Xie, Pengfei Shan, Zhuo-Xian Meng   +14 more
openaire   +2 more sources

Glutamine synthetase activity and the expression of three glul paralogues in zebrafish during transport

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2012
The enzyme glutamine synthetase (GS; glutamate-ammonia ligase, EC 6.3.1.2) plays an important role in the nitrogen metabolism of fish. In this study the GS activity and the corresponding genes were examined to understand how they are regulated in zebrafish in response to hyperammonemic stress during a 72 h simulated transport. Whole body ammonia levels,
Anusha K S, Dhanasiri, Jorge M O, Fernandes, Viswanath, Kiron   +2 more
openaire   +2 more sources

GLUL drives metabolic reprogramming and confers docetaxel resistance in prostate cancer

Biochemical Pharmacology
Docetaxel is a first-line chemotherapeutic agent for advanced and castration-resistant prostate cancer (CRPC), yet acquired resistance limits its long-term efficacy. Metabolic reprogramming has emerged as a central mechanism of therapeutic resistance; however, the metabolic determinants of docetaxel resistance remain incompletely defined.Here, we ...
Zihang Wu, Xiangwei Wang, Ran Xu, Yuqi wu, Qiuxia Ding, Wei Huang, Yuanfei Huang, Ying Zhang   +7 more
openaire   +1 more source

Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia

Psychiatric Genetics, 2009
As dysfunction of glutamatergic neurotransmission is one of the plausible hypotheses for the pathogenesis of schizophrenia, genes involved in the glutamate neurotransmitter system are candidates for schizophrenia susceptibility. The aim of this study is to clarify the contribution of two genes encoding glutamate metabolic enzymes: the glutamic acid ...
Shinsaku, Arai, Hiroki, Shibata, Mayumi, Sakai, Hideaki, Ninomiya, Nakao, Iwata, Norio, Ozaki, Yasuyuki, Fukumaki   +6 more
openaire   +2 more sources

m6A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression

Journal of Hazardous Materials
Hexavalent chromium [Cr(VI)] exposure increases the risk of cancer occurrence. This study found that the levels of an atypical methyltransferase, METTL16 were greatly upregulated in the cells, and mouse tissues with Cr(VI) exposure, and played a critical role in cell proliferation and tumor growth induced by Cr(VI).
Jian-Ge Qiu, Mingliang He, Bing-Hua Jiang   +2 more
exaly   +3 more sources

Downregulation of miR-127-5p promotes idiopathic epiretinal membrane development via GLUL-mediated Müller cell activation

Experimental Eye Research
Idiopathic epiretinal membrane (iERM) represents a fibrocellular proliferation on retinal surface associated with vision loss, with underlying molecular mechanisms that remain undefined. The current work aimed to assess miR-127-5p for its role in the regulation of retinal Müller cell activity in iERM.
Jian Zou, Quanyong Yi, Danxue He
exaly   +3 more sources