Glutamine synthetase sustains cortical circuit development via mTOR-mediated astrocyte maturation. [PDF]
Gong P +12 more
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Early Müller Glial Activation and Retinal Ganglion Cell Synaptic Dysfunction in APP/PS1 Mice. [PDF]
Zhou Y +8 more
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Multi-omics characterization of diabetic nephropathy in the db/db mouse model of type 2 diabetes. [PDF]
Wang L +6 more
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Prefrontal Cortex Dysregulation of Amino Acid-Glucose Homeostasis Links High-Fat and/or High-Fructose Intake to Cognitive Deficits in Male Mice. [PDF]
Martínez-Orozco H +4 more
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SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes. [PDF]
Marsal-Beltran A +20 more
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Responses of Soil Nitrogen-Cycling Microbial Communities and Functional Potential to Grazing Intensities in Alpine Meadows. [PDF]
Qie T +6 more
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Serum Proteomic Profile Based on the TGF-β Pathway Stratifies Risk of Hepatocellular Carcinoma. [PDF]
Xiang X +19 more
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Integration of single-cell and RNA-seq analysis reveals sepsis heterogeneity and prognostic significance of FCGR3A+ Macrophage subtypes. [PDF]
He Y +5 more
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Variable expression of hepatic genes in different liver tumor cell lines: conclusions for drug testing. [PDF]
Wisniewska MJ +7 more
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GLUL Promotes Cell Proliferation in Breast Cancer
Journal of Cellular Biochemistry, 2017Glutamate-ammonia ligase (GLUL) belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. Here, we found higher expression of GLUL in the breast cancer patients was associated with larger tumor size and higher level of HER2 expression.
Jun Lu, Shaohua Fan, Dongmei Wu
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