Results 111 to 120 of about 4,820 (182)

Additional file 2: of Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

, 2019
Figure with gene expression of SLC1A5, GLS1, GLUL, and GLUD1 in 19 basal-like and 7 luminal B PDX models. The gene expression data of SLC1A5, GLS1, GLUL, and GLUD1 in 19 basal-like PDX tumors (red) and 7 basal-like PDX tumors (cyan) is presented in ...
Jana Kim (6701069), Morten Rye (725101), Maria Grinde (6701054), Bylgja Hilmarsdottir (207231), Gunhild MĂŚlandsmo (5515103), Siver Moestue (6701075), Hanna Tunset (6701063), Mads Haugen (6701072), Ida Henriksen (6701066)   +8 more
core   +1 more source

Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer

Scientific Reports
This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and the risk of gastric cancer using a two-sample Mendelian randomization approach.
Wenhai Fan, Zhenjiang Wu, Shenghao Xu, Zhiheng Liu, Yiming Huang, Pan Wang   +5 more
doaj   +1 more source

Neuroprotective effects of L-Dopa-modified zinc oxide nanoparticles on the rat model of 6-OHDA-ınduced Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the ‘on–off’
Yesim Yeni, Sıdıka Genc, Muhammed Sait Ertugrul, Hayrunnisa Nadaroglu, Arzu Gezer, Ali Sefa Mendil, Ahmet Hacımuftuoglu   +6 more
doaj   +1 more source

The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the potential targets and mechanisms of Draconis Sanguis (DS), a valuable traditional Chinese medicine derived from the resin of the palm tree Daemonorops draco Bl (D. Sanguis, Xue Jie), in the treatment of myocardial infarction
Keyan Wang, Rongxin Zhu, Junjun Li, Binhua Yuan, Xiang Li, Yunlin Li, Mingyue Huang, Fangfang Rui, Chun Li, Wei Wang   +9 more
doaj   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science
Serine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one‐carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one‐carbon metabolism is reported in both Parkinson's disease (PD) patients and animal models ...
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
doaj   +1 more source

P648: De novo GLUL missense variant in individual with neurodevelopmental disorder prompts ClinGen gene curation, ClinVar submission, and new GeneMatcher cohort [PDF]

Eleanor P. Fensterle, Kimberly A. Foss, Scott A. Melville, Bradford Powell, Stephanie L. Peck, Senyene Hunter, Tam P. Sneddon   +6 more
openalex   +1 more source

The Glutamine Synthetases Are Required for Sensory Hair Cell Formation and Auditory Function in Zebrafish

The development of sensory hair cells (HCs) is closely linked to hearing loss. There are still many unidentified genes that may play a crucial role in HC development and function.
Yuanrong Zhao, Guanyun Wei, Fuping Qian, Ziyang Wang, Mengting Xu, Dong Liu   +5 more
core   +1 more source

AR-Induced RP11-893F2.9 Drives Glutamine-Fatty Acid Metabolic Reprogramming and Malignant Behaviors in ccRCC

Background Clear cell renal cell carcinoma (ccRCC) exhibits a high metabolic plasticity and a poor prognosis. However, the mechanisms of long non-coding RNA (lncRNA) RP11-893F2.9 affect the prognosis of ccRCC through metabolic pathways remains unclear ...
Kefeng Wang, Chunming Zhu, Hongyuan Liang, Dan Dong, Puguang Yu, Liqun Yang, Ruiming Li, Peng Su, Yibing Wang   +8 more
core   +1 more source

Biomimicry TRPV1 agonist 6SA attenuates corticosterone-induced depression via targeting Glul-Gm57375 signaling in microglia

Yilu Sun, Weiyao Liao, Stephen Cho Wing Sze, Yibin Feng, Jianhui Rong, Jia Zhao   +5 more
openalex   +1 more source

Human M1-macrophages secrete glutamine: a role for the transporters ASCT2 and SNAT5

Previous results indicated that LPS treatment of human macrophages is associated with the induction of glutamate-ammonia-ligase (GLUL)GLUL, the enzyme that synthesizes glutamine, although the effects on cell Gln level were not assessed by those studies ...
Chiara Ughini, Martina Chiu, Roberta Andreoli, Marco Ventura, Ovidio Bussolati, Chiara Maccari, Giulia Longhi, Massimiliano G Bianchi, Giuseppe Taurino   +8 more
core   +1 more source