Results 101 to 110 of about 4,820 (182)

RHBG and GLUL are highly expressed in HepG2 hepatoma cells.

, 2015
A) The level of mRNA expression of RHBG in HEK293T, HepG2 and Hep3B cells was determined by qRT-PCR and normalized to β-actin. B) The mRNA expression of GLUL in HepG2 and Hep3B was determined by qRT-PCR.
Jennifer Victoria Alberola (747939), Anna Maria Marini (445235), Christelle De Mees (445233), Rami Abdo (747938), Ahmad Merhi (224244)   +4 more
core   +1 more source

Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy [PDF]

, 2015
PurposeValproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia. However, the mechanism responsible for this adverse effect is not readily apparent.
Hirai, Keita, Tsuji, Daiki, Yamamoto, Yoshiaki, Takahashi, Toshiki, Inoue, Yushi, Inoue, Kazuyuki, Itoh, Kunihiko, Suzuki, Eri, Takahashi, Yukitoshi, Imai, Katsumi   +9 more
core   +1 more source

Quantitative real-time PCR analysis of Fabp7, Gal, Glul, Igfbp3, Npy1r and Sstr1 expression in the septum.

, 2012
Relative expression distribution of mRNA (y-axis) represented as a ratio of maternal versus virgin mice, was calculated using Ywhaz and CycA as reference genes, and shown by box-and-whisker plot as medians (dashed lines), interquartile range (boxes) and ...
Stephen C. Gammie (89652), Terri Driessen (160124), Michael C. Saul (160120), Changjiu Zhao (160116)   +3 more
core   +1 more source

Increased glutamine anabolism sensitizes non-small cell lung cancer to gefitinib treatment [PDF]

, 2018
To better understand the resistance mechanism of non-small cell lung cancers (NSCLCs) to gefitinib, the metabolic profiles of gefitinib-resistant A549 cells and gefitinib-sensitive PC-9 cells were analyzed with a metabolomics analytical platform.
Deng, Pengchi, Zhao, Ying-Lan, Wu, Tianming, Peng, Wen, Wang, Liang   +4 more
core   +1 more source

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Medeniyet Medical Journal
Objective: Metabolic rewiring is a characteristic of cancer cells. Cancer cells require more nutrients for survival and proliferation. Although glutamine can be produced in cells via a series of enzymatic reactions, a group of cancer cells are dependent ...
Ahsen Merve BAYRAK, Burcu YUCEL
doaj   +1 more source

Cellular localization of Prss56 and Glul in B6 (C57BL/6J) and Mfrp^rd6/Mfrp^rd6 mice.

, 2014
(A) By in situ hybridization, in B6 (C57BL/6J) controls at P14, we observed Prss56 transcript in only very few cells of the inner nuclear layer (INL) of the retina (top panel), whereas in Mfrprd6/Mfrprd6 mutants, an intense staining of Prss56 transcript ...
Timothy M. Stearns (304280), Jeremy R. Charette (651917), Ramani Soundararajan (651915), Jürgen K. Naggert (223486), Mark P. Krebs (651919), Patsy M. Nishina (651920), Gayle B. Collin (223482), Wanda L. Hicks (651918), Jungyeon Won (651916)   +8 more
core   +1 more source

Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration

, 2019
Glutamate-ammonia ligase (glutamine synthetase; Glul) is enriched in astrocytes and serves as the primary enzyme for ammonia detoxification and glutamate inactivation in the brain.
Dhaher, Roni, Parent, Maxime, Hyder, Fahmeed, Hu, Qiu Xiang, Zhou, Yun, Yee, Siu-Pok, Hassel, Bjørnar, Gruenbaum, Shaun E., Eid, Tore, Danbolt, Niels Christian   +9 more
core   +1 more source

Investigating autophagy and glutamine metabolism as therapeutic targets for pancreatic cancer.

, 2015
381 Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer, for which new therapeutic approaches are urgently needed.
Donald Yapp, Sharon Gorski, David Schaeffer, Daniel John Renouf, Paalini Sathiyaseelan, Nancy Erro Go, Christina Iggulden, Mario Jardon, Steve Kalloger   +8 more
core   +1 more source

Impaired E-cadherin expression and glutamine synthetase overexpression in solid pseudopapillary neoplasm of the pancreas

, 2008
OBJECTIVES: To analyze in solid pseudopapillary neoplasm of the pancreas (SPNP) the consequences of the deregulated Wnt pathway by studying the expression of Wnt target glutamine synthetase (GLUL), cyclin D1, and E-cadherin, which is one of the beta ...
Audard, Virginie, Flejou, Jean-Francois, Terris, Benoit, Cavard, Catherine, Richa, Hubert, Couvelard, Anne, Genevay-Infante, Muriel, Paye, Francois, Sauvanet, Alain   +8 more
core   +1 more source

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
doaj   +1 more source