Results 91 to 100 of about 7,364 (182)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Journal of Neuroinflammation, 2019
Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals.
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda   +5 more
doaj   +1 more source

Specific Nature of Hydrolysis of Insulin and Tobacco Mosaic Virus Protein by Thermolysin [PDF]

Oxidized bovine insulin and tobacco mosaic virus protein used to determine hydrolysis specificity of ...
Jukes, T. H., Matsubara, H., Sasaki, R., Singer, A.   +3 more
core   +1 more source

Symmetric signaling by an asymmetric 1 erythropoietin : 2 erythropoietin receptor complex [PDF]

, 2008
Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2008.Includes bibliographical references (p. 43-46).One erythropoietin molecule binds asymmetrically to two identical receptor monomers via erythropoietin site 1 ...
Zhang, Yingxin
core  

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Medeniyet Medical Journal
Objective: Metabolic rewiring is a characteristic of cancer cells. Cancer cells require more nutrients for survival and proliferation. Although glutamine can be produced in cells via a series of enzymatic reactions, a group of cancer cells are dependent ...
Ahsen Merve BAYRAK, Burcu YUCEL
doaj   +1 more source

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways [PDF]

, 2017
Intrahepatic malignant tumours include hepatocellular carcinomas (HCC), cholangiocarcinomas (CC) and combined hepatocholangiocarcinomas (cHCC-CC), a group of rare and poorly characterized tumours that exhibit both biliary and hepatocytic differentiation.
Audebourg, Anne, Cavard, Catherine, Clément, Bruno, Coulouarn, Cédric, Dumont, Florent, Gilgenkrantz, Hélène, Jacques, Sébastien, Just, Pierre-Alexandre, Perret, Christine, Rubbia-Brandt, Laura, Terris, Benoît   +10 more
core  

Microwave beam power [PDF]

Information on microwave beam power is given in viewgraph form. Information is given on orbit transfer proulsion applications, costs of delivering 100 kWe of usable power, and costs of delivering a 1 kg payload into ...
Faymon, Karl A.
core   +1 more source

RIP Kinase-Mediated Necrosis as an Alternative Mechanism of Photoreceptor Death [PDF]

, 2013
Photoreceptor cell death is the terminal event in a variety of retinal disorders including age-related macular degeneration, retinitis pigmentosa, and retinal detachment.
Miller, Joan Whitten, Murakami, Yusuke, Vavvas, Demetrios   +2 more
core  

Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations [PDF]

, 2019
Stem cell populations within developing embryos are diverse, composed of many different subpopulations of cells with varying developmental potential. The structure of stem cell populations in cell culture remains poorly understood and presents a barrier ...
Chen, Sisi, Park, Jong H., Rivaud, Paul, Thomson, Matt, Tsou, Tiffany   +4 more
core  

Adaptation to acetaminophen exposure elicits major changes in expression and distribution of the hepatic proteome. [PDF]

Acetaminophen overdose is the leading cause of acute liver failure. One dose of 10-15 g causes severe liver damage in humans, whereas repeated exposure to acetaminophen in humans and animal models results in autoprotection.
A Bertola, A Enomoto, AM Larson, AS Kienhuis, B Eckes, CE Goldring, CJ Omiecinski, CJ Patten, DJ Antoine, DJ Antoine, E Wojcik, H Irie, HE Poulsen, HS Buttar, J Borlak, J Sastre, JR Foster, K Chan, K Dalhoff, K Itoh, LM Aleksunes, M Hadi, M McMahon, M Zeisberg, MA O’Connor, O Strubelt, OH Lowry, P Galand, PR Bushel, PT Manyike, R Buhler, RC Dart, RM Shayiq, S Chanda, S Guo, S Muzeeb, S Rudraiah, SD Ryder, T Oinonen, Y Ito, Y Kurumiya   +40 more
core   +1 more source