Results 91 to 100 of about 4,820 (182)

Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. METHODS Using aged mice, we examined the impact of abdominal surgery on cognition, glymphatic activity, and astrocyte function.
Yuto Hasegawa, Hiroki Kawai, Robyn Wiseman, Gianluca Ursini, Hannah Alton, Feiyi Xiong, Sohan Gummadi, Naomi Mao, Kyle Mailhot, Yannan Li, Xiaolei Zhu, Tomoyo Sawada, Barbara Slusher, Atsushi Kamiya   +13 more
wiley   +1 more source

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

PLoS ONE, 2014
BackgroundHypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma.
Alexandra Arreola, C Lance Cowey, Jonathan L Coloff, Jeffrey C Rathmell, W Kimryn Rathmell   +4 more
doaj   +1 more source

Glutamine Synthetase (GLUL) and Glutaminase GLS Immunohistochemistry in Breast Cancer in Tissue Microarrays with Quantitative Image Analysis

, 2018
Today, breast cancer is one of the most common cancer in women. Approximately 1 out of 8 women in the United States will develop invasive breast cancer over the course of their lifetime.
Ovalle, Gabriela, Jacobsen, Max
core   +1 more source

Enzyme activity measurements of GAD1, GLUL, and ALDH5A1 in PNEC cells following pH stress.

, 2014
The effects of 24-hour acid and alkaline stress on A. GAD1, B. GLUL, and C. ALDH5A1 levels in PNEC cells were measured. D. Protein expression of enzymes correlates with enzyme activities. Beta actin (ACTB) is provided as a loading control.
David Piwnica-Worms (178244), Joseph E. Ippolito (523145)   +1 more
core   +1 more source

Ion channels and atrial fibrillation: mitophagy as a key mediator

Frontiers in Physiology
BackgroundThe prevalence of atrial fibrillation (AF) is increasing due to the aging population. Mitophagy is crucial for maintaining cardiomyocyte function, while ion channels play a key role in cardiac electrical activity.
Xize Wu, Xiaorui Yan, Ruoxi Ma, Qiuying Wu, Xue Pan, Qihua Wu, Jiaqi Ren, Yuxi Huang, Shan Gao, Yue Li, Lihong Gong   +10 more
doaj   +1 more source

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Journal of Neuroinflammation, 2019
Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals.
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda   +5 more
doaj   +1 more source

Localization of KGA, GAC and GLUL relative to mitofilin in quiescent and activated CD4⁺ T cells.

, 2016
α-CD3/CD28 stimulated (+) and unstimulated (-) CD4+ T cells incubated under hypoxia (H) and normoxia (N) were examined by confocal microscopy after immunofluorescence staining using Alexa Flour 488 (green) conjugated α-KGA (A), α-GAC (B) and α-GLUL (C ...
Fritjof H. Cederkvist (3146061), Halvor L. Holen (3146067), Zeynep Sener (3146064), Bjørn S. Skålhegg (171469), Roman Volchenkov (3146058)   +4 more
core   +1 more source

Enzyme activity measurements of GAD1, GLUL, and ALDH5A1 in PNEC cells following nutrient deprivation.

, 2014
The effects of 24-hour glucose and glutamine deprivation on A. GAD1, B. GLUL, and C. ALDH5A1 levels in PNEC cells were measured. D. Protein expression of enzymes correlate with enzyme activities.
David Piwnica-Worms (178244), Joseph E. Ippolito (523145)   +1 more
core   +1 more source

TERT silencing alters the expression of ARG1, GLUL, VIM, NES genes and hsa-miR-29b-3p in the T98G cell line

, 2022
The central function of telomerase is maintaining the telomere length. However, several extra-telomeric roles have been identified for this protein complex.
Andrés Aristizabal-Pachon (14277982), Yeimy González-Giraldo (4599061), Ángela Y. García Fonseca (14277979)   +2 more
core   +1 more source