Results 71 to 80 of about 4,187 (148)

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

S100A8+S100A9+ transitional macrophages are associated with pulmonary fibrosis progression by integrating immunometabolism and fibrogenic crosstalk

Frontiers in Immunology
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. Although macrophage heterogeneity has been implicated in pathogenesis, the contribution of transitional macrophage states remains ...
Censhan Lin, Mingyue Wu, Mingyue Wu, Ziying Zhang, Muxu Zheng, Huiqin Li, Huiqin Li, Yufang Wang, Zhanxin Du, Linxiang Wu, Junjie Dai, Yu Yu, Xuhang Du, Yehui Wu, Jie Xu, Jie Xu, Zhongxing Wang, Fu-Li Xiang, Fu-Li Xiang   +18 more
doaj   +1 more source

Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment

Journal of Neuroinflammation, 2019
Background Extracellular vesicles (EVs) are nano-sized particles present in most body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in HIV+ individuals.
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda   +5 more
doaj   +1 more source

AMPK Activation in TET2 Downregulated Leukemia Cells Upon Glutamine Limitation

Medeniyet Medical Journal
Objective: Metabolic rewiring is a characteristic of cancer cells. Cancer cells require more nutrients for survival and proliferation. Although glutamine can be produced in cells via a series of enzymatic reactions, a group of cancer cells are dependent ...
Ahsen Merve BAYRAK, Burcu YUCEL
doaj   +1 more source

cpt1b Regulates Cardiomyocyte Proliferation Through Modulation of Glutamine Synthetase in Zebrafish

Journal of Cardiovascular Development and Disease
Carnitine palmitoyltransferase 1b (Cpt1b) is a crucial rate-limiting enzyme in fatty acid metabolism, but its role and mechanism in early cardiac development remains unclear. Here, we show that cpt1b regulates cardiomyocyte proliferation during zebrafish
Xiaohan Cheng, Jingyi Ju, Wenping Huang, Zongyi Duan, Yanchao Han   +4 more
doaj   +1 more source

Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer

Scientific Reports
This study aimed to elucidate the potential causal relationship between 4,907 plasma proteins and the risk of gastric cancer using a two-sample Mendelian randomization approach.
Wenhai Fan, Zhenjiang Wu, Shenghao Xu, Zhiheng Liu, Yiming Huang, Pan Wang   +5 more
doaj   +1 more source

The cardioprotective mechanisms of draconis sanguis: An integrated network pharmacology, bioinformatics, and experimental validation study

Journal of Traditional Chinese Medical Sciences
Objective: To investigate the potential targets and mechanisms of Draconis Sanguis (DS), a valuable traditional Chinese medicine derived from the resin of the palm tree Daemonorops draco Bl (D. Sanguis, Xue Jie), in the treatment of myocardial infarction
Keyan Wang, Rongxin Zhu, Junjun Li, Binhua Yuan, Xiang Li, Yunlin Li, Mingyue Huang, Fangfang Rui, Chun Li, Wei Wang   +9 more
doaj   +1 more source

Neuroprotective effects of L-Dopa-modified zinc oxide nanoparticles on the rat model of 6-OHDA-ınduced Parkinson’s disease

Scientific Reports
Parkinson’s disease (PD) is a chronic neurodegenerative case. As the disease progresses, the response time to doses of levodopa (L-Dopa) becomes shorter and the effects of the drug are severely limited by some undesirable side effects such as the ‘on–off’
Yesim Yeni, Sıdıka Genc, Muhammed Sait Ertugrul, Hayrunnisa Nadaroglu, Arzu Gezer, Ali Sefa Mendil, Ahmet Hacımuftuoglu   +6 more
doaj   +1 more source

Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats

Frontiers in Pharmacology
Chronic liver disease, a long-term condition resulting from various causes such as alcohol abuse, metabolic disorders, and viral hepatitis, is becoming a significant global health challenge.
Yu Chen, Lizhou Ma, Yibo Wang, Jiarui Zhang, Tianhe Pei, Miao Wang   +5 more
doaj   +1 more source

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science
Serine Hydroxymethyltransferase 1 (SHMT1) plays a pivotal role in one‐carbon metabolism, facilitating the production of SAM. In this study, dysregulation of one‐carbon metabolism is reported in both Parkinson's disease (PD) patients and animal models ...
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
doaj   +1 more source