Results 61 to 70 of about 4,820 (182)
Molecular Metabolism, 2022 Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes.
Ji Min Park +10 more
doaj +1 more source
, 2022 Nasopharyngeal carcinoma (NPC) is often associated with the infection of Epstein-Barr virus in nasopharynx and is mainly happened in South China and Southeast Asia. Recently, noncoding RNAs have been reported to regulate NPC carcinogenesis.
Xiaomeng Zhang (182897) +7 more
core +1 more source
HIF2 glutamine utilization is deterred by Glul expression.
, 2014 (A) Glul knockdown by siRNA in HIF2dPA+ cells was ∼15% compared to untreated cells as confirmed by qRT-PCR. (B) Knockdown of Glul in HIF2dPA+ cells in 2 mM L-glutamine-supplemented media showed an increase in OCR over HIF2dPA+ cells. OCR levels decreased
Jeffrey C. Rathmell (570389) +4 more
core +1 more source
Advanced Science, EarlyView.This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang +5 more
wiley +1 more source
Frontiers in Microbiology, 2022 Endo-β-1,4-glucanase is a crucial glycoside hydrolase (GH) involved in the decomposition of cellulosic materials. In this study, to discover a novel cold-adapted β-1,4-D-glucan-degrading enzyme, the gene coding for an extracellular endo-β-1,4-glucanase ...
Do Young Kim +8 more
doaj +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Cancer Science, EarlyView.Antiandrogen‐resistant prostate cancer cells acquire ferroptosis resistance through AMPKα activation and upregulation of ferroptosis suppressor pathways. This adaptive state creates a therapeutic vulnerability, as GPX4 inhibition, particularly in combination with AMPKα inhibition, effectively suppresses the growth of resistant cells.
Masaki Shiota +8 more
wiley +1 more source
The FEBS Journal, EarlyView.MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz +13 more
wiley +1 more source
The expression of GAC, KGA and GLUL is differentially regulated under normoxia and hypoxia.
, 2016 (A) RT-qPCR analysis of GAC, KGA, GLUL and HIF-1α expression after 72 hours of α-CD3/CD28 stimulation. Gene expression values were presented normalized to unstimulated cells after 72h of incubation.
Fritjof H. Cederkvist (3146061) +4 more
core +1 more source
Quantitative Comparative Proteomics Reveal Biomarkers for Dengue Disease Severity
Frontiers in Microbiology, 2019 Dengue fever (DF) could develop into dengue haemorrhagic fever (DHF) with increased mortality rate. Since the clinical characteristics and pathogen are same in DF and DHF.
Lifen Han +6 more
doaj +1 more source