Results 61 to 70 of about 4,187 (148)

Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Perioperative neurocognitive disorder is a common and debilitating complication in the elderly, yet its cellular and molecular mechanisms in the aging brain remain poorly understood. METHODS Using aged mice, we examined the impact of abdominal surgery on cognition, glymphatic activity, and astrocyte function.
Yuto Hasegawa, Hiroki Kawai, Robyn Wiseman, Gianluca Ursini, Hannah Alton, Feiyi Xiong, Sohan Gummadi, Naomi Mao, Kyle Mailhot, Yannan Li, Xiaolei Zhu, Tomoyo Sawada, Barbara Slusher, Atsushi Kamiya   +13 more
wiley   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

PO-249 GLUL knockdown induces drug resistance in non-small cell lung cancer cells

ESMO Open, 2018
ABSTRACT Introduction Chemotherapy has advanced well in the treatment of Non-Small Cell Lung Cancers (NSCLCs), but its effectiveness is limited by drug resistance. Unfortunately, cancer drug resistance becoming inevitable involving alterations in epigenetic regulation, molecular signalling, and metabolic rewiring.
M. Muthu, A. Nordstrom
openaire   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, Volume 26, Issue 7, Page 111-130, July 2026.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression

Clinical and Translational Medicine
Background Triple‐negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein‐coupled estrogen receptor (GPER), a novel estrogen receptor, is linked
Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu   +13 more
doaj   +1 more source

Mitochondrial Dysfunction at the Crossroads of Necroptosis: Mechanisms, Molecular Mediators, and Therapeutic Opportunities

Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.
ABSTRACT The conceptual landscape of cell death has evolved beyond the traditional dichotomy of apoptosis and necrosis to encompass diverse regulated pathways including necroptosis, autophagy, ferroptosis, and pyroptosis. Necroptosis, a caspase‐independent inflammatory form of programmed cell death, has emerged as a critical driver of the pathogenesis ...
Fengxin Wang, Haiying Rui, Dandan Qin, Huaxiang Yu, Dan Zou, Wenyi Zou, Yuting Li, Ran Li, Yuguo Chen, Li Xue   +9 more
wiley   +1 more source

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

Single‐Nucleus RNA‐Seq Reveals Neuroprotective Effects of Acupuncture in Chronic Migraine Through Modulation of Glial Subtypes

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Acupuncture Alleviates Chronic Migraine by Reprogramming Glial Cells and Restoring Neuronal Homeostasis in the Trigeminal Nucleus Caudalis. It suppresses inflammatory and oxidative stress responses, rebalances neuronal excitability and metabolism, drives microglia and astrocytes toward reparative states, and reconstructs impaired neuron–glia ...
Shiqi Sun, Shuangyuan Hu, Mingsheng Sun, Zili Tang, Yuyan Wang, Longyao Xu, Puhua Cao, Lu Liu, Rong Wang, Jing Yuan, Ying Chen, Ling Zhao   +11 more
wiley   +1 more source

HIF1α and HIF2α exert distinct nutrient preferences in renal cells.

PLoS ONE, 2014
BackgroundHypoxia Inducible Factors (HIF1α and HIF2α) are commonly stabilized and play key roles related to cell growth and metabolic programming in clear cell renal cell carcinoma.
Alexandra Arreola, C Lance Cowey, Jonathan L Coloff, Jeffrey C Rathmell, W Kimryn Rathmell   +4 more
doaj   +1 more source