Results 81 to 90 of about 4,820 (182)

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle.

PLoS Pathogens
In prion diseases (PrDs), aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Davide Caredio, Maruša Koderman, Karl J Frontzek, Silvia Sorce, Mario Nuvolone, Juliane Bremer, Giovanni Mariutti, Petra Schwarz, Lidia Madrigal, Marija Mitrovic, Stefano Sellitto, Nathalie Streichenberger, Claudia Scheckel, Adriano Aguzzi   +13 more
doaj   +1 more source

Self‐Organized Vascularized Human Liver Spheroids: Serum‐Free Culture Conditions and Use as Tissue Building Blocks

Small, Volume 22, Issue 49, 1 September 2026.
This approach addresses a major challenge in tissue engineering: creating larger, vascularized tissues. Microvascular networks in liver spheroids are developed through self‐organization mediated by mesenchymal stem cells. These spheroids are maintained in serum‐reduced or serum‐free medium and serve as building blocks to form planar tissue layers ...
Alina Filatova, Olivera Valentirović Dann, Jennifer B. Schwarzkopf, Tengku I. Maulana, Jamina S. Gerhardus, Leon Kaysan, Katja Meier, Andreas Blaeser, Beate K. Straub, Holger Gerhardt, Ulrike A. Nuber   +10 more
wiley   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1613-1632, August 2026.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Exploration, Volume 6, Issue 4, August 2026.
Obesity‐linked hypercoagulation is driven by fibrinogen overproduction in a specific hepatocyte cluster via IL6 signalling. Genetic and mechanistic studies reveal this pathway as a key target for therapies to mitigate clotting risks and associated complications in obese individuals.
Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng, Ziyi Yang, Yue Liu, Yonghui Jiang, Tao Zhu, Teng Liu, Yunfei Xu, Chang Pan, Han Zhao, Shaozhuang Liu, Shigang Zhao, Zi‐Jiang Chen   +14 more
wiley   +1 more source

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis [PDF]

, 2018
Glutamine synthetase, encoded by the gene GLUL, is an enzyme that converts glutamate and ammonia to glutamine. It is expressed by endothelial cells, but surprisingly shows negligible glutamine-synthesizing activity in these cells at physiological ...
Wyns, Sabine, Dewerchin, M, Johan Hofkens, Gervasio, Francesco L., Comitani, F, Gervasio, FL, Federico Comitani, van Buul, Jaap D, Cruys, Bert, Annalisa Zecchin, Cruys, B, Peter Carmeliet, Brepoels, Katleen, Gervasio, Francesco L, Leanne Ramer, Saar Vandekeere, Dewerchin, Mieke, Zecchin, A, Rocha, S, Li, Xuri, Huang, Hongling, Lucas Treps, Comitani, Federico, Dubois, Charlotte, Joanna Kalucka, Schoonjans, L, Jaap D. van Buul, Wyns, S, Dubois, C, Lange, Christian, Treps, Lucas, Brüning, U, Eelen, G, Saladino, G, Lamers, WH, Anna Rita Cantelmo, Kalucka, J, Wu, Y, Wu, Yi, Wu, X, van Buul, Jaap D., Jarugumilli, G, Chen, Rongyuan, Brepoels, K, Ramer, Leanne, Rocha, Susana, Ghesquiere, Bart, Charlotte Dubois, Jos van Rijssel, Schoonjans, Luc, Souffreau, Joris, Ghesquière, B, Morales-Rodriguez, Francisco, Xuri Li, Ramer, L, Guy Eelen, Bert Cruys, Treps, L, Vinckier, Stefan, Cubbon, R, Giorgio Saladino, Joris Souffreau, Liekens, S, Liekens, Sandra, Wu, Xu, Lamers, Wouter H., Cubbon, Richard, Mieke Dewerchin, Richard Cubbon, Lange, C, Sabine Wyns, Wouter H. Lamers, Ulrike Brüning, Stefan Vinckier, Souffreau, J, Hofkens, Johan, Susana Rocha, Christian Lange, Luc Schoonjans, Carmeliet, Peter, Michael DeRan, Goveia, Jermaine, Francesco L. Gervasio, DeRan, Michael, Katleen Brepoels, Lamers, Wouter H, Rongyuan Chen, Bruning, Ulrike, Cantelmo, AR, Francisco Morales-Rodriguez, Vandekeere, S, van Rijssel, J, Vinckier, S, Jarugumilli, Gopala, Hofkens, J, Hongling Huang, Carmeliet, P, Zecchin, Annalisa, DeRan, M, Chen, R, van Buul, JD, Haustraete, J, Eelen, Guy, Saladino, Giorgio, Gopala Jarugumilli, Cantelmo, Anna Rita, Jurgen Haustraete, Jermaine Goveia, Bart Ghesquière, Xu Wu, Goveia, J, Vandekeere, Saar, Sandra Liekens, Kalucka, Joanna, Huang, H, van Rijssel, Jos, Haustraete, Jurgen, Li, X, Yi Wu, Morales-Rodriguez, F   +119 more
core   +2 more sources

Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes

Glia, Volume 74, Issue 8, August 2026.
Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi, Katarzyna M. Tyc, Lauren Dain, Maryam Ashrafi Kheirabadi, Jennifer Hanco, Karli Mockenhaupt, Soha Munir, Adam McQuiston, Sandeep K. Singh, Tomasz Kordula   +9 more
wiley   +1 more source

Microenvironmental G protein‐coupled estrogen receptor‐mediated glutamine metabolic coupling between cancer‐associated fibroblasts and triple‐negative breast cancer cells governs tumour progression

Clinical and Translational Medicine
Background Triple‐negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein‐coupled estrogen receptor (GPER), a novel estrogen receptor, is linked
Chongwu He, Meixi Peng, Xiaoqiang Zeng, Hanzhi Dong, Zhengkui Sun, Jiawei Xu, Manran Liu, Liyan Liu, Yanxiao Huang, Zhiqiang Peng, Yu‐An Qiu, Chunling Jiang, Bin Xu, Tenghua Yu   +13 more
doaj   +1 more source

High‐throughput multispecies quantitative polymerase chain reaction assays to study the effects of acute thermal stress in three species of Acipenser sturgeon

Journal of Fish Biology, Volume 109, Issue 2, Page 899-914, August 2026.
Abstract Fishes experience thermal stress in their natural environment that can be caused by natural or anthropogenic factors and can directly affect their physiology. In this study, we developed a multispecies OpenArray™ qPCR (quantitative polymerase chain reaction) ‘chip’ to measure the effects of acute thermal stress on the mRNA response of ...
Hossein Haghighi, Kyle Madden, William S. Bugg, Faith M. Penny, Scott A. Pavey, Nicholas J. Bernier, Kenneth M. Jeffries   +6 more
wiley   +1 more source

Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction

Frontiers in Immunology
BackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity.
Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng   +6 more
doaj   +1 more source