GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer
Acta Pharmaceutica Sinica BGlutamate-ammonia ligase (GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation.
Qiwei Jiang +11 more
doaj
Diabetes, 2015 Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D).
semanticscholar +1 more source
Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway [PDF]
, 2009 Deamidation of N-terminal Gln by Nt^Q-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of protein degradation. We detected the activity of Nt^Q-amidase, termed Ntaq1, in mouse tissues, purified Ntaq1 from bovine brains ...
Brower, Christopher S. +3 more
core +1 more source
DIFFERENTIAL ACTIVITY AND CONTENT OF HIGH-AFFINITY GLUTAMATE TRANSPORTERS, CONTENT OF THEIR REGULATORY PROTEINS, AND CAPACITY FOR GLUTAMINE AND GLUTATHIONE SYNTHESIS IN TISSUES OF FINISHED VERSUS GROWING STEERS [PDF]
, 2017 Improvement of feeding regimens for production animals has been hindered by a lack of fundamental knowledge about how the capacity to regulate nutrient absorption across cell membranes affects the function of nutrient metabolizing enzymes.
Huang, Jing
core +1 more source
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]
, 2008 Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama +4 more
core +1 more source
Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle
, 2015 Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents ...
Capuani, Fabrizio +3 more
core +1 more source
The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan [PDF]
, 2018 BACKGROUND: rs10911021 (a single nucleotide polymorphism present upstream of the GLUL gene) affects glutamic acid metabolism, and was shown to be associated with coronary heart disease (CHD) in patients with T2DM but a definite mechanism is unknown.
Humphries, Shabana +2 more
core
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria [PDF]
The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and ...
Barber, Abigail R +30 more
core +1 more source
Involvement of Serine Threonine Protein Kinase, PknL, from Mycobacterium Tuberculosis H37Rv in Starvation Response of Mycobacteria [PDF]
, 2000 The adaptation to nutrient depletion in bacteria involves a highly organized series of intracellular events that enable them to adapt to starvation conditions.
Lakshminarayan, H +2 more
core
On an RNA-membrane protogenome [PDF]
arXivSelected ribonucleotide sequences bind well to zwitterionic phospholipid bilayer membranes, though randomized RNAs do not. There are no evident repeated sequences in selected membrane binding RNAs. This implies small and varied motifs responsible for membrane affinity. Such subsequences have been partially defined. Bound RNAs require divalents like Mg2+
arxiv