Results 81 to 90 of about 7,778 (157)

The impact of genetic polymorphisms in glutamate-cysteine ligase, a key enzyme of glutathione biosynthesis, on Ischemic stroke risk and brain infarct size [PDF]

, 2022
The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (GCLC) and modifier (GCLM) subunits of glutamate-cysteine ligase, a rate-limiting enzyme in glutathione synthesis, play a role in the development of ...
Klyosova, E., Polonikov, A., Bocharova, I., Azarova, I., Churnosov, M.   +4 more
core  

Concentration-Dependent Processivity of Multiple Glutamate Ligations Catalyzed by Folylpoly-γ-glutamate Synthetase [PDF]

, 2016
Folylpoly-γ-glutamate synthetase (FPGS, EC 6.3.2.17) is an ATP-dependent ligase that catalyzes formation of poly-γ-glutamate derivatives of reduced folates and antifolates such as methotrexate and 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDAH4PteGlu1 ...
Richard G. Moran (1318314), John W. Tomsho (2010013), James K. Coward (2298190)   +2 more
core   +1 more source

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle [PDF]

In prion diseases (PrDs), aggregates of misfolded prion protein (PrP$^{Sc}$) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Madrigal, Lidia, Aguzzi, Adriano; https://orcid.org/, Koderman, Maruša; https://orcid.org/, Frontzek, Karl J; https://orcid.org/, Sorce, Silvia; https://orcid.org/, Sellitto, Stefano; https://orcid.org/, Streichenberger, Nathalie, Nuvolone, Mario; https://orcid.org/, Bremer, Juliane; https://orcid.org/, Scheckel, Claudia; https://orcid.org/, Caredio, Davide; https://orcid.org/, Mariutti, Giovanni, Mitrovic, Marija, Schwarz, Petra; https://orcid.org/   +13 more
core   +3 more sources

The JBS-associated E3 Ligase UBR-1 Maintains Synaptic Glutamate Homeostasis and Regulates Neurotransmitter Balance [PDF]

, 2015
Johanson-Blizzard Syndrome (JBS) is a rare, sometimes fatal autosomal recessive multi-systemic congenital genetic disorder, characterized by pancreatic exocrine insufficiency and mental retardation.
Chitturi, Jyothsna
core   +3 more sources

Identification and characterization of proteins interacting with metabotropic glutamate receptor subtype 8 [PDF]

, 2005
Group III presynaptic metabotropic glutamate receptors (mGluRs) play a central role in regulating presynaptic activity through G-protein effects on ion channels and signal transducing enzymes.
Tang, Z., Tang, Zhongshu
core  

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

In-silico study of potential carboxylic acid derivatives as D-glutamate ligase inhibitors in Salmonella typhi [PDF]

, 2018
Salmonella typhi is food-borne as well as water-borne pathogen, which is the main cause of typhoid fever. This disease is affecting people in both developing and underdeveloped countries. The emergence of multidrug resistance in S.
Hina Mushtaq, Tahira Mobeen, Muhammad I. Qadir   +2 more
core   +1 more source

Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications. [PDF]

Amino Acids
Fang J, Ling J, Liu X, Wang Y, Huang Y, Cao Z, Zou Y, Xiong H.   +7 more
europepmc   +1 more source

A Novel Gain-of-Function GLUL Variant Is Associated With Developmental and Epileptic Encephalopathy With Enlarged Perivascular Spaces. [PDF]

Hum Mutat
Wu T, He F, Ni X, Yin F, Peng J.
europepmc   +1 more source

Machine learning-driving optimization and spatial assembly of a cell-free system for high-yield liquiritigenin production. [PDF]

Adv Biotechnol (Singap)
Liu F, Zhao SB, Liu YH, Li JF, Lin NQ, Mutailifu M, Xu P, Liu JZ.   +7 more
europepmc   +1 more source