Results 61 to 70 of about 7,748 (154)

Metaproteome Analysis of Short‐Term Thermal Stress in Three Sympatric Coral Species Reveals Divergent Host Responses

Ecology and Evolution, Volume 16, Issue 3, March 2026.
Short‐term thermal stress triggers distinct molecular responses in three sympatric coral species with contrasting thermal resilience. Proteomic and metabolomic profiling reveal both species‐specific and limited shared pathways underlying these stress responses.
Shrinivas Nandi, Timothy G. Stephens, Erin E. Chille, Samantha Goyen, Line K. Bay, Debashish Bhattacharya   +5 more
wiley   +1 more source

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene

, 2006
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients’ cerebrospinal fluid and prefrontal cortex.
Do, Kim Quang, Cuénod, Michel, Solida, Alessandra, Deppen, Patricia, Matthey, Marie-Louise, Parnas, Josef, Preisig, Martin, Bovet, Pierre, Barral, Sandra, Gheorghita, Fulvia, Quang Do, Kim, Ott, Jurg, Wang, August G., Timm, Sally, Saraga, Michael, Werge, Thomas, Wang, August G, Tosic, Mirjana   +17 more
core   +1 more source

Assessment of Metabolites in Noni Fruit Slurry Fermented With Four Non‐Saccharomyces Yeasts

Food Frontiers, Volume 7, Issue 2, March 2026.
Dried noni fruit slurry (DNFS) was fermented for 14 days with selected non‐Saccharomyces yeasts. GCMS, HPLC and amino acid analysis showed that Pichia kluyveri Frootzen and Williopsis saturnus NCYC22 grew well, reduced off‐flavor fatty acids, generated fruity aroma compounds and preserved total phenolic content. ABSTRACT Noni products often suffer from
Zhuoran Zhang, Shao Quan Liu, Yuyun Lu
wiley   +1 more source

Microglial glutathione and glutamate: regulation mechanisms

, 2009
Microglia, the immune cells of the central nervous system (CNS), are important in the protection of the CNS, but may be implicated in the pathogenesis of neuroinflammatory disease.
Fry, V.A.H.
core  

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Elongation of the poly-γ-glutamate tail of F420 requires both domains of the F420:γ-glutamyl ligase (FbiB) of Mycobacterium tuberculosis

, 2016
Cofactor F420 is an electron carrier with a major role in the oxidoreductive reactions of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
Rehan, AM, Sreebhavan, S, Squire, Christopher, Sreebhavan, Sreevalsan, Baker, Heather, Baker, Edward N., Baker, Edward, Baker, Heather M., Mohamed Rehan, Aisyah, Squire, Christopher J., Bashiri, Ghader   +10 more
core   +1 more source

Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells

, 1981
Ragg H, Kuhn DN, Hahlbrock K. Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells. J. Biol. Chem.
Hahlbrock, Klaus, Ragg, Hermann, Kuhn, David N   +2 more
core  

The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in C. elegans

, 2018
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C.
Renee Baran, Min Wu, James W. Dennis, John Calarco, Xun Huang, Mei Zhen, Anas M. Abdel Rahman, Jyothsna Chitturi, Wesley Hung, Maria A. Lim   +9 more
core   +1 more source

Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Glutamate Cysteine Ligase

, 2009
Glutathione is a thiol-disulfide exchange peptide critical for buffering oxidative or chemical stress, and an essential cofactor in several biosynthesis and detoxification pathways.
Barycki, Joseph J., Biterova, Ekaterina I.   +1 more
core