Results 61 to 70 of about 7,778 (157)

The Early Response to Urea, Nitrate, or Ammonium and Iron Resupply in Tomato Roots Highlights the Induction of FER, bHLHs, UMAMITs, and MATEs

Physiologia Plantarum, Volume 178, Issue 4, July/August 2026.
ABSTRACT Depending on the nitrogen (N) form available to roots, plants activate different transcriptional and metabolic pathways; this can consequently translate into differences in the composition and release of root exudates. To address the existing knowledge gap regarding the relationship between the availability of Iron (Fe) and different N forms ...
Arianna Lodovici, Leilei Zhang, Nicola Tomasi, Gabriella Vinci, Fabio Marroni, Barbara Piani, Fatemeh Hassanvand, Mustapha Arkoun, Luigi Lucini, Laura Zanin   +9 more
wiley   +1 more source

Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells [PDF]

, 2017
For decades, Chinese hamster ovary (CHO) cells have been the preferred host for therapeutic monoclonal antibody (mAb) production; however, increasing mAb titer by rational engineering remains a challenge.
Orellana, Camila A., Gray, Peter P., Nielsen, Lars K., Marcellin, Esteban   +3 more
core   +1 more source

Metabolic design considerations for recycling of respiratory CO2 in leaves

The Plant Journal, Volume 127, Issue 1, July 2026.
SUMMARY Net carbon gain in plants is significantly reduced by the loss of assimilated carbon due to respiration and other metabolism in heterotrophic tissues. Avoiding this loss is difficult due to the essential nature of the metabolic processes involved but it could be possible to engineer metabolism to reuse the generated CO2.
Corinna Hartinger, Edward N. Smith, Lee J. Sweetlove   +2 more
wiley   +1 more source

Postnatal development of rat retina: a continuous observation and comparison between the organotypic retinal explant model and in vivo development

Neural Regeneration Research
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.
Baoqi Hu, Rui Wang, Hanyue Zhang, Xiou Wang, Sijia Zhou, Bo Ma, Yan Luan, Xin Wang, Xinlin Chen, Zhichao Zhang, Qianyan Kang   +10 more
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science
Glioblastoma (GBM) is a malignant brain tumor characterized by profound angiogenic activity and immunosuppressive features. A burgeoning body of research has focused on elucidating the functional effects of stromal cells within the tumor microenvironment
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
doaj   +1 more source

The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma [PDF]

Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High‐fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis.
Xinran Liu, Desheng Hu, Ling Zheng, Liangliang Song, Churong Zou, Huidie Xu, Yihao Zhou, Jing Yang, Chen Wang, Yushuo Xiao, Robert B Petersen, Anlin Peng, Junqiu Yue, Qiujin Ma, Yuchen Chen, Yu Sun, Jiajian Shi, Kun Huang, Hong Chen, Yangkai Li, Zhao Jia, Chuyao Ma   +21 more
core   +1 more source

The two major pathways metabolizing ammonia: the urea cycle (periportal), and glutamine synthesis (pericentral). [PDF]

, 2014
In the urea cycle: ammonia and bicarbonate form carbamoylphosphate via carbamoyl phosphate synthetase1 (CPS1). This reaction requires N-acetylglutamate (acquired via a reaction catalysed by N-acetylglutamate synthase (NAGS)), Mg2+ and MgATP ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons

BMC Genomics
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified.
Fei Ye, Zhi-dan Deng, Kun-yu Liu, Xiu-mei Yao, Wen-xiao Zheng, Qiong Yin, Xiang Hai, Jian-kang Gan, Zheng-Fen Zhang, Zheng Ma, Hua Li   +10 more
doaj   +1 more source