Results 61 to 70 of about 12,640 (161)

Quantitative constraint-based computational model of tumor-to-stroma coupling via lactate shuttle

, 2015
Cancer cells utilize large amounts of ATP to sustain growth, relying primarily on non-oxidative, fermentative pathways for its production. In many types of cancers this leads, even in the presence of oxygen, to the secretion of carbon equivalents ...
Capuani, Fabrizio, De Martino, Andrea, De Martino, Daniele, Marinari, Enzo   +3 more
core   +1 more source

Valproate induces the unfolded protein response by increasing ceramide levels [PDF]

, 2016
Bipolar disorder (BD), which is characterized by depression and mania, affects 1–2% of the world population. Current treatments are effective in only 40–60% of cases and cause severe side effects.
Cottier, Stéphanie, Cowart, Ashley, Greenberg, Miriam L., Jadhav, Shyamalagauri, Russo, Sarah, Schneiter, Roger   +5 more
core   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

Oxidative stress: a systemic factor implicated in the pathogenesis of hepatic encephalopathy [PDF]

, 2012
Although ammonia is considered the main factor involved in the pathogenesis of hepatic encephalopathy (HE), it correlates well with the severity of HE in acute liver failure, but not in chronic liver disease.
Bosoi, Cristina R., Rose, Christopher
core   +1 more source

Postnatal development of rat retina: a continuous observation and comparison between the organotypic retinal explant model and in vivo development

Neural Regeneration Research
The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell cultures.
Baoqi Hu, Rui Wang, Hanyue Zhang, Xiou Wang, Sijia Zhou, Bo Ma, Yan Luan, Xin Wang, Xinlin Chen, Zhichao Zhang, Qianyan Kang   +10 more
doaj   +1 more source

Yeast cell factories for fine chemical and API production [PDF]

, 2008
This review gives an overview of different yeast strains and enzyme classes involved in yeast whole-cell biotransformations. A focus was put on the synthesis of compounds for fine chemical and API (= active pharmaceutical ingredient) production employing
Beate Pscheidt, Anton Glieder
core   +3 more sources

Microbial metabolites in tumor epigenetic regulation

iMeta, Volume 5, Issue 1, February 2026.
The gut microbiome modulates tumor epigenetic regulation through bioactive metabolites derived from dietary substrates. Microbiota‐produced SCFAs, secondary BAs, one‐carbon metabolites, and tryptophan‐derived ligands regulate histone acetylation, DNA methylation, and chromatin remodeling via HDAC, DNMT, AhR, and metabolic cofactor‐dependent pathways ...
Wangzheqi Zhang, Haoling Zhang, Yan Liao, Shuya Jiang, Haolong Zhang, Chenwei Huang, Zhijing Song, Rui Zhao, Ping Lu, Xiaohong Kang, Eryan Kong, Yalin Zhu, Wei Wang, Xuesong Liu, Yisheng Chen, Zhiwen Luo, Zhaoyu Li, Di Wang, Na Xing, Yadong Guo, Jingjing Zhang, Xiaojing Wang, Wenyi Wang, Mowaffaq Adam, Bakiah Shaharuddin, Muhamad Yusri Musa, Doblin Sandai, Chenglong Zhu, Aimin Jiang, Peng Luo, Zhijie Zhao, Zui Zou   +31 more
wiley   +1 more source

Combined Analysis of Transcriptome and Metabolome Explains the Differences in Pulp Color in Jackfruit

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT The pulp color of jackfruit reflects variations in its nutritional composition and influences market preference. We investigated the mechanism underlying pulp coloration through an integrated transcriptomic and metabolomic analysis of three jackfruit cultivars—light yellow “THA”, yellow “GTM”, and orange “YNH”.
Jianjun Liang, Xiangwei Ma, Chenxin Yi, Hailan Zhou, Zhuangmin Wei, Xiuguan Tang, Weiyan Ye, Hailing Tang, Pengjin Zhu   +8 more
wiley   +1 more source

Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons

BMC Genomics
Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified.
Fei Ye, Zhi-dan Deng, Kun-yu Liu, Xiu-mei Yao, Wen-xiao Zheng, Qiong Yin, Xiang Hai, Jian-kang Gan, Zheng-Fen Zhang, Zheng Ma, Hua Li   +10 more
doaj   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source