Results 41 to 50 of about 7,748 (154)

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase [PDF]

, 2015
INTRODUCTION: Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR).
Kwiatkowski, David J., Urbanska, M., Kotulska, Katarzyna, Perycz, Malgorzata, Malgorzata Perycz, Ewa Liszewska, Lukasz J. Swiech, Iyer, Anand M., Borkowska, J., Jaworski, Jacek, Zarebska, Malgorzata M., Jozwiak, Sergiusz, Jaworski, J., Borkowska, Julita, Eleonora Aronica, Swiech, L.J., Tyburczy, M.E., Agnieszka Skalecka, Urbanska, Malgorzata, Pietruszka, Patrycja, Patrycja Pietruszka, Sergiusz Jozwiak, Magdalena E. Tyburczy, Wieslawa Grajkowska, Zarebska, M.M., Kamil Parobczak, Macias, M., Kwiatkowski, D.J., Jacek Jaworski, Pietruszka, P., Malik, A.R., Swiech, Lukasz J., David J. Kwiatkowski, Parobczak, K., Grajkowska, Wieslawa, Liszewska, E., Jozwiak, S., Skalecka, Agnieszka, Malgorzata Urbanska, Katarzyna Kotulska, Perycz, M., Macias, Matylda, Anand M. Iyer, Parobczak, Kamil, Skalecka, A., Iyer, A.M., Kwiatkowski, David, Grajkowska, W., Liszewska, Ewa, Aronica, E., Kotulska, K., Aronica, Eleonora, Tyburczy, Magdalena E., Matylda Macias, Anna R. Malik, Malik, Anna R., Malgorzata M. Zarebska, Julita Borkowska   +57 more
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The Chemical Structures, Neuroprotective Effects, Structure–Activity Relationships, and Applications of Flavonoids, Phenolic Acids, Terpenoids, and Sterols in Dandelion: A Review

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This review systematically summarizes the chemical structures and structure–activity relationships of key bioactive compounds in dandelion, including flavonoids, phenolic acids, terpenoids, and sterols. It highlights their neuroprotective mechanisms against neuroinflammation and oxidative stress, while outlining their promising dual applications in the
Hongye Li, Bingchan Qu, Jiasu Wu, Menghan Sun, Youlin Xue, Tiejing Li, Chang Tan, Shan Wang, Chong Ning, Chongting Guo   +9 more
wiley   +1 more source

Astrócitos e hormônio da tireóide (T3): desenvolvimento neuronal e neuroproteção [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Neurociências.O hormônio da tireóide (T3) exerce uma importante influência no desenvolvimento e maturação do SNC de mamíferos.
Aguiar, Cláudia Beatriz Nedel Mendes de
core  

Metabolic Strategies Under Heat Stress in Non‐Adapted and High‐Temperature‐Adapted Lines of a Marine Diatom

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Proteomics reveal Chaetoceros simplex‐evolved populations adopt a conservative, resource‐recycling strategy when exposed to above‐optimal temperatures. This involves downregulating biosynthesis, which helps the organism withstand heat stress. However, this strategy may limit their ability to adapt to high temperatures in environments with low nitrate ...
María Aranguren‐Gassis, Angel P. Diz, Suzana G. Leles, María Huete‐Ortega, Andrew Allen, Naomi M. Levine, Elena Litchman   +6 more
wiley   +1 more source

Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum

, 2012
Schneider J, Peters-Wendisch P, Stansen KC, et al. Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum. BMC Microbiology.
Götker Susanne, Stanislav, Maximov, Schneider Jens, Stanislav Maximow, Stansen K Corinna, K Corinna Stansen, Susanne Götker, Reinhard Krämer, Peters-Wendisch Petra, Krämer, Reinhard, Schneider, Jens, Wendisch Volker F, Götker, Susanne, Wendisch, Volker F. ; https://orcid.org/, Volker F Wendisch, Petra Peters-Wendisch, Stansen, K. C., Jens Schneider, Krämer Reinhard, Maximow Stanislav, Peters-Wendisch, Petra   +20 more
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Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study [PDF]

, 2022
Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated in ...
Klyosova, E. Y., Azarova, I. E., Bykanova, M. A., Solodilova, M. A., Churnosov, M.   +4 more
core   +1 more source

The Seasonal and Spatial Patterns of Planktonic Bacterial and Fungal Community Structure and the Response to Environmental Factors in the Danjiangkou Reservoir, China

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study investigated the spatial and temporal distribution patterns of bacterial and fungal communities in the Danjiangkou Reservoir during dry season and wet season, revealing the mechanism by which seasonal variations drive changes in microbial community composition and function through their influence on the physicochemical properties of the ...
Yarui Cheng, Xiaoyu Lu, Zunwei Ke, Lu Gan, Yaqing Zhou, Fengjian Wang   +5 more
wiley   +1 more source

Activation of mitochondrial CPS1 promotes dormant ovarian follicle activation via arginine elevation and the mTORC1 pathway

Frontiers in Cell and Developmental Biology
BackgroundCarbamoyl phosphate synthetase 1 (CPS1) is a mitochondrial ligase essential for urea production, catalyzing the formation of carbamoyl phosphate from ammonia in a reaction requiring the allosteric activator N acetyl L glutamate (NAG).
Stine Bundgaard Birkebæk, Mahboobeh Amoushahi, Karin Lykke-Hartmann, Karin Lykke-Hartmann   +3 more
doaj   +1 more source

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Mutation screening of the glutamate cysteine ligase modifier (GCLM) gene in patients with schizophrenia.

, 2009
BACKGROUND: Experimental evidences show that glutathione and its rate-limiting synthesizing enzyme, the glutamate-cysteine ligase (GCL), are involved in the pathogenesis of schizophrenia.
Do, K.Q., Butticaz, C., Rivolta, C., Werge, T., Beckmann, J.S., Cuénod, M.   +5 more
core   +3 more sources