Results 41 to 50 of about 7,778 (157)

GLUL stabilizes N-Cadherin by antagonizing β-Catenin to inhibit the progresses of gastric cancer

Acta Pharmaceutica Sinica B
Glutamate-ammonia ligase (GLUL, also known as glutamine synthetase) is a crucial enzyme that catalyzes ammonium and glutamate into glutamine in the ATP-dependent condensation.
Qiwei Jiang, Yong Li, Songwang Cai, Xingyuan Shi, Yang Yang, Zihao Xing, Zhenjie He, Shengte Wang, Yubin Su, Meiwan Chen, Zhesheng Chen, Zhi Shi   +11 more
doaj   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Elongation of the poly-γ-glutamate tail of F420 requires both domains of the F420:γ-glutamyl ligase (FbiB) of Mycobacterium tuberculosis [PDF]

, 2016
Cofactor F420 is an electron carrier with a major role in the oxidoreductive reactions of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB).
Rehan, AM, Sreebhavan, S, Squire, Christopher, Sreebhavan, Sreevalsan, Baker, Heather, Baker, Edward N., Baker, Edward, Baker, Heather M., Mohamed Rehan, Aisyah, Squire, Christopher J., Bashiri, Ghader   +10 more
core   +1 more source

Targeting AQP5-mediated arginine deprivation in gastric cancer stem cells restores NK cell anti-tumor immunity

Cell Reports Medicine
Summary: Natural killer (NK) cells exhibit impaired anti-tumor activity upon entering the tumor microenvironment (TME); however, the precise mechanism(s) remains elusive.
Rou Zhao, Baoyu He, Lunhua Huang, Yanli Wu, Ting Liu, Jilan Liu, Mingsheng Zhao, Tao Zhong, Yanhua Zhang, Xiao Zhang, Huabao Xiong, Bin Zhang, Qingli Bie   +12 more
doaj   +1 more source

Nutrient disturbance in a shallow aquaculture pond impacts Microcystis gene expression but does not impact bacterial community function during bloom conditions

Journal of Phycology, EarlyView.
Abstract Cyanobacterial harmful algal blooms (cHABs) are worldwide issues. Reduced nitrogen forms (ammonium and urea) have recently been measured in freshwater systems at concentrations not previously recorded. These reduced nitrogen forms have been shown to favor the proliferation of harmful cyanobacteria.
Matthew F. Gladfelter, Hunter R. Baylous, Alan E. Wilson, Morgan M. Steffen   +3 more
wiley   +1 more source

Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase [PDF]

, 2015
INTRODUCTION: Tuberous sclerosis complex (TSC) is a genetic disease resulting from mutation in TSC1 or TSC2 and subsequent hyperactivation of mammalian Target of Rapamycin (mTOR).
Kwiatkowski, David J., Urbanska, M., Kotulska, Katarzyna, Perycz, Malgorzata, Malgorzata Perycz, Ewa Liszewska, Lukasz J. Swiech, Iyer, Anand M., Borkowska, J., Jaworski, Jacek, Zarebska, Malgorzata M., Jozwiak, Sergiusz, Jaworski, J., Borkowska, Julita, Eleonora Aronica, Swiech, L.J., Tyburczy, M.E., Agnieszka Skalecka, Urbanska, Malgorzata, Pietruszka, Patrycja, Patrycja Pietruszka, Sergiusz Jozwiak, Magdalena E. Tyburczy, Wieslawa Grajkowska, Zarebska, M.M., Kamil Parobczak, Macias, M., Kwiatkowski, D.J., Jacek Jaworski, Pietruszka, P., Malik, A.R., Swiech, Lukasz J., David J. Kwiatkowski, Parobczak, K., Grajkowska, Wieslawa, Liszewska, E., Jozwiak, S., Skalecka, Agnieszka, Malgorzata Urbanska, Katarzyna Kotulska, Perycz, M., Macias, Matylda, Anand M. Iyer, Parobczak, Kamil, Skalecka, A., Iyer, A.M., Kwiatkowski, David, Grajkowska, W., Liszewska, Ewa, Aronica, E., Kotulska, K., Aronica, Eleonora, Tyburczy, Magdalena E., Matylda Macias, Anna R. Malik, Malik, Anna R., Malgorzata M. Zarebska, Julita Borkowska   +57 more
core   +1 more source

Systemic acquired resistance: an emerging role for jasmonates in local signal biogenesis, translocation and distal signal decoding

New Phytologist, EarlyView.
Jasmonate signalling underpins establishment of plant systemic acquired resistance (SAR). Activation of the hypersensitive response (HR) not only contains the pathogen but establishes broad spectrum resistance in unchallenged leaves. The strong burst of reactive oxygen/nitrogen species initiating the HR results in lipid peroxidation (illustrated by ...
Fay Bennett, Erin Stroud, Pradeep Kachroo, Murray Grant   +3 more
wiley   +1 more source

Astrócitos e hormônio da tireóide (T3): desenvolvimento neuronal e neuroproteção [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Neurociências.O hormônio da tireóide (T3) exerce uma importante influência no desenvolvimento e maturação do SNC de mamíferos.
Aguiar, Cláudia Beatriz Nedel Mendes de
core  

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study [PDF]

, 2022
Glutathione is a tripeptide detoxifying a variety of exogenous and endogenous free radicals and carcinogens, and a deficiency of glutathione is associated with an increased host susceptibility to oxidative stress, a pathological condition implicated in ...
Klyosova, E. Y., Azarova, I. E., Bykanova, M. A., Solodilova, M. A., Churnosov, M.   +4 more
core   +1 more source