Results 51 to 60 of about 7,778 (157)

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Activation of mitochondrial CPS1 promotes dormant ovarian follicle activation via arginine elevation and the mTORC1 pathway

Frontiers in Cell and Developmental Biology
BackgroundCarbamoyl phosphate synthetase 1 (CPS1) is a mitochondrial ligase essential for urea production, catalyzing the formation of carbamoyl phosphate from ammonia in a reaction requiring the allosteric activator N acetyl L glutamate (NAG).
Stine Bundgaard Birkebæk, Mahboobeh Amoushahi, Karin Lykke-Hartmann, Karin Lykke-Hartmann   +3 more
doaj   +1 more source

Cotton Recruits Soil‐Derived Delftia tsuruhatensis to Suppress Aphid Detoxification Via Salicylic Acid‐Mediated Defense

Advanced Science, Volume 13, Issue 38, 9 July 2026.
This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue, Fengchao Diao, Qiqing Yu, Xiangzhen Zhu, Tingfang Zhong, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Junyu Luo, Jinjie Cui, Xueke Gao   +11 more
wiley   +1 more source

Apple Pomace Pectin for Gastroprotective Nutraceutical Delivery: Structure–Function Relationships and Nano/Microencapsulation Strategies for Gastric Ulcer Management

Food Frontiers, Volume 7, Issue 4, July 2026.
Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman, Shefali Arora, Parteek Prasher, Sukanya Chhetri, Pankaj Bhandari, William N. Setzer, Javad Sharifi‐Rad   +6 more
wiley   +1 more source

Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells [PDF]

, 1981
Ragg H, Kuhn DN, Hahlbrock K. Coordinated regulation of 4-coumarate: CoA ligase and phenylalanine ammonia-lyase mRNAs in cultured plant cells. J. Biol. Chem.
Hahlbrock, Klaus, Ragg, Hermann, Kuhn, David N   +2 more
core  

The UBR-1 Ubiquitin Ligase Regulates Glutamate Metabolism to Generate Coordinated Motor Pattern in C. elegans [PDF]

, 2018
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C.
Renee Baran, Min Wu, James W. Dennis, John Calarco, Xun Huang, Mei Zhen, Anas M. Abdel Rahman, Jyothsna Chitturi, Wesley Hung, Maria A. Lim   +9 more
core   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Mechanistic Details of Glutathione Biosynthesis Revealed by Crystal Structures of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Glutamate Cysteine Ligase [PDF]

, 2009
Glutathione is a thiol-disulfide exchange peptide critical for buffering oxidative or chemical stress, and an essential cofactor in several biosynthesis and detoxification pathways.
Barycki, Joseph J., Biterova, Ekaterina I.   +1 more
core   +1 more source

Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers. [PDF]

, 2003
The antioxidant glutathione (GSH) is increased in the epithelial lining fluid (ELF) of chronic smokers. The rate-limiting enzyme in GSH synthesis is glutamate-cysteine ligase (GCL), also known as γ‐glutamylcysteine synthetase, consisting of a heavy,
Behr, J., Lenz, A.-G., Ding, I., Kolbe, T., Leuchte, H., Neurohr, C.   +5 more
core   +1 more source

Phytoplasma Effector SJP8 Suppresses Host Immunity by Promoting the Degradation of ZjMYB15 and ZjMYB86‐like to Perturb Jasmonic Acid and Hydrogen Peroxide Homeostasis in Jujube

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
SJP8 suppresses plant immunity by perturbing JA and H2O2 homeostasis via the SJP8‐ZjMYB15/ZjMYB86‐like‐ZjJAIPHX1/ZjPOD43 module, leading to dwarfism and chlorosis. ABSTRACT ‘Candidatus Phytoplasma ziziphi’ infection causes severe damage to jujube (Ziziphus jujuba), inducing symptoms such as branch clustering, dwarfism, chlorosis and phyllody, leading ...
Ying Yang, Haizhen Nie, Weikai Chen, Yaru Xu, Bo Wu, Ling Ma, Zhonghua Liu, Xiaoming Pang   +7 more
wiley   +1 more source