Results 71 to 80 of about 12,640 (161)

Discovering functional gene expression patterns in the metabolic network of with wavelets transforms [PDF]

, 2006
Background Microarray technology produces gene expression data on a genomic scale for an endless variety of organisms and conditions. However, this vast amount of information needs to be extracted in a reasonable way and funneled into manageable and ...
Zapatka Marc, Sager Sebastian, Seitz Hanna, Oswald Marcus, Schramm Gunnar, König Rainer, Reinelt Gerhard, Eils Roland   +7 more
core   +2 more sources

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, Volume 293, Issue 3, Page 781-805, February 2026.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer [PDF]

, 2018
During tumorigenesis, the high metabolic demand of cancer cells results in increased production of reactive oxygen species. To maintain oxidative homeostasis, tumor cells increase their antioxidant production through hyperactivation of the NRF2 pathway ...
Altman, Biancur, Boulahbel, Briggs, Cairns, Cancer Genome Atlas Research Network, Chandel, Chio, Cong, Cox, Davidson, Davies, DeBerardinis, DeBerardinis, DeBerardinis, Deberardinis, DeNicola, Dixon, Fabrizio, Fellmann, Fernandez, Gaglio, Gao, Goldstein, Gorrini, Habib, Hanada, Hanahan, Hosios, Hu, Ishii, Itoh, Itoh, Jaramillo, Kim, King, Kobayashi, Konermann, Konstantinopoulos, Koppula, Lacey, Lane, Larson, Le Gal, Letouzé, Lewerenz, Lewis, Loenarz, Mayers, Mitsuishi, Muscarella, Nicklin, Nioi, Piskounova, Qie, Rhoads, Romero, Sato, Sayin, Sayin, Selak, Shibata, Shibata, Shin, Singh, Sleeman, Son, Taguchi, Tardito, Timmerman, Trachootham, Vander Heiden, Warburg, Watanabe, Waterfall, Welbourne, Wise, Wise, Xiang, Xiao, Yuneva, Yuneva   +81 more
core   +1 more source

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy

Advanced Science, Volume 13, Issue 2, 9 January 2026.
REEP1 contributes to endoplasmic reticulum (ER) shaping. Variants either cause cortical motoneuron degeneration and hereditary spastic paraplegia (HSP) or spinal motoneuron degeneration and distal hereditary motor neuropathy (dHMN). Knockout causes less complex ER structures and cortical motoneuron loss.
Andrea Bock, Mona Schurig, Miles Willoughby, Andrea Mirecki, Eric Seemann, Kateryna Lohachova, Istvan Katona, Sonnhild Mittag, Lutz Liebmann, Patricia Franzka, Mehdi Heidari Horestani, Mukhran Khundadze, Thorsten Mosler, Timothy Louie, Marianne de Visser, Marian A. J. Weterman, Michael Kiehntopf, Christian Beetz, Sandor Nietzsche, Otmar Huber, Joachim Weis, Michael M. Kessels, Ramachandra M. Bhaskara, Britta Qualmann, Ivan Đikić, Christian A. Hübner   +25 more
wiley   +1 more source

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

Co-Cultures of Oophila Amblystomatis Between Ambystoma Maculatum and Ambystoma Gracile Hosts Show Host-Symbiont Fidelity [PDF]

, 2019
A unique symbiosis occurs between embryos of the spotted salamander (Ambystoma maculatum) and a green alga (Oophila amblystomatis). Unlike most vertebrate host-symbiont relationships, which are ectosymbiotic, A.
Burns, John, Hill, Elizabeth M., Kerney, Ryan R., Kim, Eunsoo, Leavitt, Jasper S., Zhang, Huanjia   +5 more
core   +1 more source

Unprecedented Nitrite‐Dependent Aromatic Amination to Synthesize 2,4‐Diamino‐3‐Hydroxybenzoic Acid

ChemBioChem, Volume 27, Issue 2, January 2026.
By comparing the biosynthetic gene clusters for natural products with 2,4‐diamino‐3‐hydroxybenzoic acid (2,4,3‐DAHBA) moiety and heterologous expression in Streptomyces albus, we identified nine genes required for the biosynthesis of 2,4,3‐DAHBA, including nitrite biosynthesis genes.
Ko Kuwabara, Yohei Katsuyama, Yasuo Ohnishi   +2 more
wiley   +1 more source

Global transcriptome response in during growth on ribose [PDF]

, 2011
Background Lactobacillus sakei is valuable in the fermentation of meat products and exhibits properties that allow for better preservation of meat and fish. On these substrates, glucose and ribose are the main carbon sources available for growth. We used
Naterstad Kristine, Snipen Lars, McLeod Anette, Axelsson Lars   +3 more
core   +2 more sources

Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1 [PDF]

, 2011
We investigated the effect of methionine sulfoximine (MetSox), a potent inhibitor of glutamine synthetase, on Mycobacterium tuberculosis. M. tuberculosis encodes four glutamine synthetases, of which MetSox targets the type I enzyme encoded by glnA1 ...
Butcher, Philip D, Carroll, Paul, Parish, Tanya, Waddell, Simon J   +3 more
core   +2 more sources

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates [PDF]

, 2017
Glutamine synthetase (GS) plays an essential role in metabolism by catalyzing the synthesis of glutamine from glutamate and ammonia. Our recent study showed that CRBN, a direct protein target for the teratogenic and antitumor activities of ...
Cathers, Brian E., Deshaies, Raymond J., Li, Jing, Lu, Chin-Chun (Jean), Lu, Gang, Mamrosh, Jennifer L., Nguyen, Van Thang   +6 more
core   +2 more sources