Results 71 to 80 of about 7,748 (154)

Glutamate-cysteine ligase modulatory subunit in BAL alveolar macrophages of healthy smokers.

, 2003
The antioxidant glutathione (GSH) is increased in the epithelial lining fluid (ELF) of chronic smokers. The rate-limiting enzyme in GSH synthesis is glutamate-cysteine ligase (GCL), also known as γ‐glutamylcysteine synthetase, consisting of a heavy,
Behr, J., Lenz, A.-G., Ding, I., Kolbe, T., Leuchte, H., Neurohr, C.   +5 more
core   +1 more source

Genome-Wide Proteomics and Quantitative Analyses on Halophilic Archaea [PDF]

, 2008
The aerobic, haloalkaliphilic archaeon Natronomonas pharaonis is able to survive in salt-saturated lakes of pH 11. With genome-wide shotgun proteomics, 886 soluble proteins (929 proteins in total) of the theoretical Natronomonas pharaonis soluble ...
Konstantinidis, Konstantinos, Konstantinidis, K.   +1 more
core  

Overexpression of the regulatory subunit of glutamate-cysteine ligase enhances monoclonal antibody production in CHO cells

, 2017
For decades, Chinese hamster ovary (CHO) cells have been the preferred host for therapeutic monoclonal antibody (mAb) production; however, increasing mAb titer by rational engineering remains a challenge.
Orellana, Camila A., Gray, Peter P., Nielsen, Lars K., Marcellin, Esteban   +3 more
core   +1 more source

The impact of genetic polymorphisms in glutamate-cysteine ligase, a key enzyme of glutathione biosynthesis, on Ischemic stroke risk and brain infarct size [PDF]

, 2022
The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (GCLC) and modifier (GCLM) subunits of glutamate-cysteine ligase, a rate-limiting enzyme in glutathione synthesis, play a role in the development of ...
Klyosova, E., Polonikov, A., Bocharova, I., Azarova, I., Churnosov, M.   +4 more
core  

Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle [PDF]

In prion diseases (PrDs), aggregates of misfolded prion protein (PrP$^{Sc}$) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally.
Madrigal, Lidia, Aguzzi, Adriano; https://orcid.org/, Koderman, Maruša; https://orcid.org/, Frontzek, Karl J; https://orcid.org/, Sorce, Silvia; https://orcid.org/, Sellitto, Stefano; https://orcid.org/, Streichenberger, Nathalie, Nuvolone, Mario; https://orcid.org/, Bremer, Juliane; https://orcid.org/, Scheckel, Claudia; https://orcid.org/, Caredio, Davide; https://orcid.org/, Mariutti, Giovanni, Mitrovic, Marija, Schwarz, Petra; https://orcid.org/   +13 more
core   +2 more sources

ISG15 Enhances the Activity of γ‐Glutamate Cysteine Ligase to Suppress Apoptosis in High Fat Diet‐Promoted Hepatocellular Carcinoma

Obesity is a leading risk factor for development of hepatocellular carcinoma (HCC). High‐fat intake produces cytotoxic effects in liver cells, such as excessive reactive oxygen species (ROS) accumulation and apoptosis.
Xinran Liu, Desheng Hu, Ling Zheng, Liangliang Song, Churong Zou, Huidie Xu, Yihao Zhou, Jing Yang, Chen Wang, Yushuo Xiao, Robert B Petersen, Anlin Peng, Junqiu Yue, Qiujin Ma, Yuchen Chen, Yu Sun, Jiajian Shi, Kun Huang, Hong Chen, Yangkai Li, Zhao Jia, Chuyao Ma   +21 more
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The two major pathways metabolizing ammonia: the urea cycle (periportal), and glutamine synthesis (pericentral).

, 2014
In the urea cycle: ammonia and bicarbonate form carbamoylphosphate via carbamoyl phosphate synthetase1 (CPS1). This reaction requires N-acetylglutamate (acquired via a reaction catalysed by N-acetylglutamate synthase (NAGS)), Mg2+ and MgATP ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans

, 2018
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C.
Xun Huang (163341), Mei Zhen (42801), Anas M. Abdel Rahman (1908946), Renee Baran, Anas M Abdel Rahman, Maria A Lim, Mei Zhen, Min Wu (41570), Maria A. Lim (5094416), Renee Baran (366407), James W. Dennis (308813), Jyothsna Chitturi, Wesley Hung, Min Wu, James W. Dennis, James W Dennis, Wesley Hung (42797), Jyothsna Chitturi (5094419), John Calarco, Xun Huang, John Calarco (5094422), Anas M. Abdel Rahman, Maria A. Lim   +22 more
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In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes

, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer’s disease (AD), major depressive ...
Kesheng Wang, Liu, Ying, Jeddidiah W. D. Griffin, Griffin, Jeddidiah W.D., Ying Liu, Wang, Kesheng, Bradshaw, Patrick C., Patrick C. Bradshaw   +7 more
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Antibody characteristics, manufacturers, dilutions and protocol specifications for immunohistochemistry.

, 2014
CPS1, carbamoyl phosphate synthetase 1; OTC, ornithine carbamoyltransferase; ASS1, argininosuccinate synthetase; ASL, argininosuccinate lyase; ARG1, arginase; GLUL, glutamate–ammonia ligase; ABD, antibody diluent (DAKO); PBS, Phosphate-buffered saline ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source