Results 71 to 80 of about 7,778 (157)

The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans [PDF]

, 2018
UBR1 is an E3 ubiquitin ligase best known for its ability to target protein degradation by the N-end rule. The physiological functions of UBR family proteins, however, remain not fully understood. We found that the functional loss of C.
Xun Huang (163341), Mei Zhen (42801), Anas M. Abdel Rahman (1908946), Renee Baran, Anas M Abdel Rahman, Maria A Lim, Mei Zhen, Min Wu (41570), Maria A. Lim (5094416), Renee Baran (366407), James W. Dennis (308813), Jyothsna Chitturi, Wesley Hung, Min Wu, James W. Dennis, James W Dennis, Wesley Hung (42797), Jyothsna Chitturi (5094419), John Calarco, Xun Huang, John Calarco (5094422), Anas M. Abdel Rahman, Maria A. Lim   +22 more
core   +1 more source

Metabolic Strategies Under Heat Stress in Non‐Adapted and High‐Temperature‐Adapted Lines of a Marine Diatom

Environmental Microbiology, Volume 28, Issue 6, June 2026.
Proteomics reveal Chaetoceros simplex‐evolved populations adopt a conservative, resource‐recycling strategy when exposed to above‐optimal temperatures. This involves downregulating biosynthesis, which helps the organism withstand heat stress. However, this strategy may limit their ability to adapt to high temperatures in environments with low nitrate ...
María Aranguren‐Gassis, Angel P. Diz, Suzana G. Leles, María Huete‐Ortega, Andrew Allen, Naomi M. Levine, Elena Litchman   +6 more
wiley   +1 more source

Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes

Cardiovascular Diabetology
Background A common genetic variant at the glutamate-ammonia ligase (GLUL) locus has been previously associated with an increased risk of coronary artery disease (CAD) as well as alterations of glutamic acid metabolism and the γ-glutamyl cycle in ...
Fernando M. A. Giuffrida, Sharan K. Rai, Yaling Tang, Christine Mendonça, Scott G. Frodsham, Hetal S. Shah, Marcus G. Pezzolesi, Qi Sun, Alessandro Doria   +8 more
doaj   +1 more source

The Seasonal and Spatial Patterns of Planktonic Bacterial and Fungal Community Structure and the Response to Environmental Factors in the Danjiangkou Reservoir, China

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
This study investigated the spatial and temporal distribution patterns of bacterial and fungal communities in the Danjiangkou Reservoir during dry season and wet season, revealing the mechanism by which seasonal variations drive changes in microbial community composition and function through their influence on the physicochemical properties of the ...
Yarui Cheng, Xiaoyu Lu, Zunwei Ke, Lu Gan, Yaqing Zhou, Fengjian Wang   +5 more
wiley   +1 more source

In Silico Preliminary Association of Ammonia Metabolism Genes GLS, CPS1, and GLUL with Risk of Alzheimer’s Disease, Major Depressive Disorder, and Type 2 Diabetes [PDF]

, 2018
Ammonia is a toxic by-product of protein catabolism and is involved in changes in glutamate metabolism. Therefore, ammonia metabolism genes may link a range of diseases involving glutamate signaling such as Alzheimer’s disease (AD), major depressive ...
Kesheng Wang, Liu, Ying, Jeddidiah W. D. Griffin, Griffin, Jeddidiah W.D., Ying Liu, Wang, Kesheng, Bradshaw, Patrick C., Patrick C. Bradshaw   +7 more
core   +1 more source

Antibody characteristics, manufacturers, dilutions and protocol specifications for immunohistochemistry. [PDF]

, 2014
CPS1, carbamoyl phosphate synthetase 1; OTC, ornithine carbamoyltransferase; ASS1, argininosuccinate synthetase; ASL, argininosuccinate lyase; ARG1, arginase; GLUL, glutamate–ammonia ligase; ABD, antibody diluent (DAKO); PBS, Phosphate-buffered saline ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Primers used for qPCR. [PDF]

, 2014
CPS1, carbamoyl phosphate synthetase 1; OTC, ornithine carbamoyltransferase; ASS1, argininosuccinate synthetase; ASL, argininosuccinate lyase; ARG1, arginase; NAGS, N-acetylglutamate synthase; GLUL, glutamate–ammonia ligase; GLUD1, glutamate ...
Giora van Straten (580550), Frank C. P. Holstege (117137), Robert P. Favier (144780), Marian J. A. Groot Koerkamp (117136), Frank G. van Steenbeek (194928), Hille Fieten (144796), Ingrid H. van Gils (580551), Guy C. M. Grinwis (165277), Bart Spee (66184), Jan Rothuizen (66188), Anne Kummeling (381713)   +10 more
core   +1 more source

Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits [PDF]

, 2011
Glutamate cysteine ligase (GCL) deficiency is a rare autosomal recessive trait that compromises production of glutathione, a critical redox buffer and enzymatic cofactor.
Simpson, Melanie A., Ekaterina I. Biterova, Neely Willis, Melanie, Yilin Liu, Melanie A. Simpson, Heejeong Kim, Melanie Neely Willis, Barycki, Joseph J., Biterova, Ekaterina I., Lee, Jaekwon, Liu, Yilin, Joseph J. Barycki, Kim, Heejeong, Jaekwon Lee   +13 more
core   +2 more sources

Genome-Wide Proteomics and Quantitative Analyses on Halophilic Archaea [PDF]

, 2008
The aerobic, haloalkaliphilic archaeon Natronomonas pharaonis is able to survive in salt-saturated lakes of pH 11. With genome-wide shotgun proteomics, 886 soluble proteins (929 proteins in total) of the theoretical Natronomonas pharaonis soluble ...
Konstantinidis, Konstantinos, Konstantinidis, K.   +1 more
core  

Activation of glutamate-cysteine ligase in lymphocytes [PDF]

, 2000
Thesis (Ph. D.)--University of Washington, 2000Lymphocytes are normally quiescent cells that react to receptor-based signals by developing into functional effector cells that orchestrate immune responses.
Krejsa, Cecile M., 1964-
core