Schematic overview of the GS/GOGAT pathway (A) and the diaminopimelate biosynthesis (B). [PDF]
GDH: glutamate dehydrogenase; GS: glutamate-ammonia ligase; GOGAT: glutamate synthase; Atase: glutamate-ammonia ligase adenylyltransferase; DapD: tetrahydrodipicolinate succinylase; Ddh: diaminopimelate dehydrogenase.
Lorenz C. Reimer (519603) +3 more
core +1 more source
Glutamate cysteine ligase (GCL) and self reported depression: An association study from the HUNT [PDF]
Glutamate cysteine ligase (GCL) and self reported depression: An association study from the ...
NR Wray (9898862) +6 more
core +3 more sources
Glutamate-ammonia ligase promotes lung cancer cell growth through an enzyme-independent upregulation of CaMK2G under a glutamine-sufficient condition [PDF]
SUMMARY Glutamate-ammonia ligase (GLUL) is highly expressed in many cancer cells. Synthesizing glutamine by its enzyme function has been found to be important for supporting cancer cell survival and growth under glutamine restriction. However, GLUL’s functions under a glutamine-sufficient condition still have not been uncovered. Here we
Zhao, Jiangsha +2 more
openaire +1 more source
Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep +29 more
core +1 more source
It has been known that glutamine synthetase (GS, L-glutamate ammonia ligase) is an enzyme that catalyzes ATP-dependent condensation of glutamate and ammonia to form glutamine, and that GS and growth hormone (GH) are proteins that are induced by ...
Nobuyuki Shirasawa +4 more
doaj +1 more source
A single random oligonucleotide 3H primer has been previously applied in random-amplified- polymorphic-DNA (RAPD)-PCR to distinguish stocked bacteria E. coli within a cocktail mixture also containing Enterococcus faecalis ...
Y C, Chen +7 more
openaire +2 more sources
Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum [PDF]
Schneider J, Peters-Wendisch P, Stansen KC, et al. Characterization of the biotin uptake system encoded by the biotin-inducible bioYMN operon of Corynebacterium glutamicum. BMC Microbiology.
Götker Susanne +20 more
core +2 more sources
Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione [PDF]
Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL with Glutathione (GSH). The three-
Salas, Cristian O. +17 more
core +1 more source
Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François +13 more
core +1 more source
Mutation screening of the glutamate cysteine ligase modifier (GCLM) gene in patients with schizophrenia. [PDF]
BACKGROUND: Experimental evidences show that glutathione and its rate-limiting synthesizing enzyme, the glutamate-cysteine ligase (GCL), are involved in the pathogenesis of schizophrenia.
Do, K.Q. +5 more
core +5 more sources

