Results 21 to 30 of about 7,748 (154)

Glutamate-ammonia ligase promotes lung cancer cell growth through an enzyme-independent upregulation of CaMK2G under a glutamine-sufficient condition [PDF]

, 2019
SUMMARY Glutamate-ammonia ligase (GLUL) is highly expressed in many cancer cells. Synthesizing glutamine by its enzyme function has been found to be important for supporting cancer cell survival and growth under glutamine restriction. However, GLUL’s functions under a glutamine-sufficient condition still have not been uncovered. Here we
Zhao, Jiangsha, Zeng, Xiankun, Hou, Steven X.   +2 more
openaire   +1 more source

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]

, 2013
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep, Munshi, T, Sanjib Bhakta (106475), Bhakta, S, Gupta, A, Gibbons, S., Simon Gibbons (391868), Nicholas H. Keep (392673), Antima Gupta, Keep, Nicholas H., Gibbons, Simon, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Juan David Guzman (392672), Gibbons, S, Simon Gibbons, Dimitrios Evangelopoulos (392671), Tulika Munshi (392669), Antima Gupta (392670), Juan David Guzman, Evangelopoulos, D, Guzman, Juan David, Gupta, Antima, Dimitrios Evangelopoulos, Munshi, Tulika, Sanjib Bhakta, Keep, NH, Guzman, Juan D., Guzman, JD, Tulika Munshi   +29 more
core   +1 more source

Glucocorticoid-Inducible Glutamine Synthetase in GH Cells of Chick Embryos, Gallus domesticus: Ontogeny of Glutamine Synthetase, GH, and Pit-1 Protein in the Pituitary Gland

The Journal of Poultry Science, 2006
It has been known that glutamine synthetase (GS, L-glutamate ammonia ligase) is an enzyme that catalyzes ATP-dependent condensation of glutamate and ammonia to form glutamine, and that GS and growth hormone (GH) are proteins that are induced by ...
Nobuyuki Shirasawa, Ying-Jie, Yoshihiro Tsuruo, Damon C. Herbert, Akira Naito   +4 more
doaj   +1 more source

Low Abundance Taxa Show Diverse Microbial Symbiotic Interactions With the Freshwater Sponge, Radiospongilla crateriformis, Pre and Post Gemmulation. [PDF]

Environ Microbiol Rep
The microbiome profile of freshwater sponges did not broadly change in taxonomy or functional profile based on metatranscriptome analysis prior to and after formation of sponge dormant bodies (gemmules). Results highlight a subset of taxa that likely associate with the sponge host in different ways from facultative to long‐term symbionts.
Strope TA, Easson CG, Fiore CL.
europepmc   +2 more sources

C-Terminal Part of Glutamate-Ammonia-Ligase Adenyltransferase Gene Identified by RAPD-HRM with 3H Primer for E. Coli Screening

Folia Biologica, 2019
A single random oligonucleotide 3H primer has been previously applied in random-amplified- polymorphic-DNA (RAPD)-PCR to distinguish stocked bacteria E. coli within a cocktail mixture also containing Enterococcus faecalis ...
Y C, Chen, Y S, Lai, D J H, Shyu, Y W, Chang, Z R, Chen, Y K, Liao, C T, Pang, K T, Chang   +7 more
openaire   +2 more sources

Molecular modeling of Trypanosoma cruzi glutamate cysteine ligase and investigation of its interactions with glutathione [PDF]

, 2011
Trypanosoma cruzi glutamate cysteine ligase (TcGCL) is considered a potential drug target to develop novel antichagasic drugs. We have used a variety of computational methods to investigate the interactions between TcGCL with Glutathione (GSH). The three-
Salas, Cristian O., Araya-Secchi, R., Salas Sanchez, Cristian Osvaldo, Pablo Thomas, Lagos, Carlos F., Thomas, P., Cristian O. Salas, Tomás Pérez-Acle, Ricardo A. Tapia, Raul Araya-Secchi, Thomas, Pablo, Tapia, Ricardo A., Pérez-Acle, T., Lagos, C.F., Araya Secchi, Raúl, Carlos F. Lagos, Tapia, R.A., Pérez-Acle, Tomás   +17 more
core   +1 more source

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François, Tom Clarke, Catherine Paradis-Bleau, Blewett, Ann, Roger C Levesque, Clark, Tom, Paradis-Bleau , Catherine, Ann Blewett, Adrian Lloyd, Levesque, Roger C., Lloyd, Adrian, François Sanschagrin, Timothy DH Bugg, Bugg, Tim   +13 more
core   +1 more source

Identification of Blood Pressure-Associated Metabolites by Integrating Metabolomic and Genetic Analysis. [PDF]

MedComm (2020)
This study identified 10 potential causality between metabolites and blood pressure and found potential genetic regulators of two metabolites. Multiomics integration revealed that a genetic variant near the omega‐3 metabolism genes (FADS1/FADS2) may influence blood pressure regulation by modulating prostaglandin E3 levels.
Liu Y, Cheng C, Pan XF, Shao W, Zhou D, Zhu Y.   +5 more
europepmc   +2 more sources

MYELOPEROXIDASE AND GLUTAMATE-CYSTEINE LIGASE POLYMORPHISMS IN TYPE 2 DIABETES MELLITUS: A PRELIMINARY STUDY

, 2014
Background: Oxidative stress can accompany the physiopathology of diabetes mellitus. Myeloperoxidase and glutamate-cysteine ligase catalytic subunit are two important substances which are connected with the maintaining of the redox balance in the body ...
Incekara, Kutluhan, Eksi, Yunus Emre, Ergen, Hayriye Arzu, KARAALI, Zeynep Ermic   +3 more
core   +1 more source

The glutamine synthetase gene family in Populus

BMC Plant Biology, 2011
Background Glutamine synthetase (GS; EC: 6.3.1.2, L-glutamate: ammonia ligase ADP-forming) is a key enzyme in ammonium assimilation and metabolism of higher plants.
Cánovas Francisco M, Kirby Edward G, Avila Concepción, Canales Javier, García-Gutiérrez Angel, Castro-Rodríguez Vanessa   +5 more
doaj   +1 more source