Results 11 to 20 of about 7,748 (154)

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain

Biomolecules, 2016
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
doaj   +3 more sources

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer. [PDF]

J Cell Mol Med
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Ong HTM, Ates E, Jung J, Sung JS, Pyun JC, Kang MJ.   +5 more
europepmc   +2 more sources

The Use of Cell-penetrating Peptide for Delivery of Recombinant Transcription Factor DNA into Primary Human Fibroblast

MCBS (Molecular and Cellular Biomedical Sciences), 2023
Background: Reprogrammed cell therapy has not been applied for clinical purposes due to the malignancy issue. The aim of this study was to design the recombinant vector of the transcription factors and analyze the effectiveness of cell-penetrating ...
Melinda Remelia, Budiman Bela, Silvia Tri Widyaningtyas, Radiana Dhewayani Antarianto, Nuzli Fahdia Mazfufah, Jeanne Adiwinata Pawitan   +5 more
doaj   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Sylke Müller, Aparicio, I., Eva-Maria Patzewitz, Perner Jan, Isabela Aparicio, Patzewitz, E.-M., Llinas, M., Storm, J., Llinas Manuel, Engel Paul C, Olszewski Kellen, Janet Storm, Perner, J., Storm Janet, Paul C Engel, Kellen Olszewski, Engel, P.C., Manuel Llinas, Olszewski, K., Muller, S., Müller Sylke, Aparicio Isabela, Patzewitz Eva-Maria, Jan Perner   +23 more
core   +1 more source

GLUL gene knockdown and restricted glucose level show synergistic inhibitory effect on the luminal subtype breast cancer MCF7 cells’ proliferation and metastasis

EXCLI Journal : Experimental and Clinical Sciences, 2023
The glutamine synthetase path is one of the most important metabolic pathways in luminal breast cancer cells, which plays a critical role in supplying glutamine as an intermediate in the biosynthesis of amino acids and nucleotides.
Arezu Karimpur Zahmatkesh, Mohammad Khalaj-Kondori, Mohammad Ali Hosseinpour Feizi, Behzad Baradaran   +3 more
doaj   +1 more source

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

Cell Reports, 2019
Summary: Glutamine is thought to play an important role in cancer cells by being deaminated via glutaminolysis to α-ketoglutarate (aKG) to fuel the tricarboxylic acid (TCA) cycle. Supporting this notion, aKG supplementation can restore growth/survival of
Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong   +28 more
doaj   +1 more source

Genome-Wide Characterization of Glutamine Synthetase Family Genes in Cucurbitaceae and Their Potential Roles in Cold Response and Rootstock-Scion Signaling Communication

Agriculture, 2021
Glutamine synthetase (GS; EC 6.3.1.2, L-glutamate: ammonia ligase ADP-forming) is the key enzyme responsible for the primary assimilation and reassimilation of nitrogen (N) in higher plants.
Xiaojun Li, Xiaohong Lu, Mengshuang Liu, Chenggang Xiang, Wenqian Liu, Cuicui Wang, Xiaojing Zhang, Tao Wang, Zixi Liu, Lihong Gao, Wenna Zhang   +10 more
doaj   +1 more source

Exercise induced upregulation of glutamate-cysteine ligase catalytic subunit and glutamate-cysteine ligase modifier subunit gene expression in Thoroughbred horses [PDF]

, 2017
Objective This study was performed to reveal the molecular structure and expression patterns of horse glutamate-cysteine ligase catalytic subunit (GCLC) and glutamate-cysteine ligase modifier subunit (GCLM) genes whose products form glutamate cysteine ...
Nam Young Kim, Jeong-Woong Park, Byung-Wook Cho, Jae-Young Choi, Seul A Hong, Kyoung-Tag Do, Ki-Duk Song   +6 more
core   +1 more source

Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis [PDF]

, 2023
Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of cancer cells are particularly vulnerable to inhibition of their cellular antioxidant capacity.
Qian Shao, Tao, Xavier, Kasano, Miki, Ishikawa, Yoshinori, Inukai, Takayuki, Miki Kasano, Daniel K Nomura, Tang, Michelle, Zhang, Lydia, Thomas, Vienna, Lydia Zhang, Michelle Tang, Saki Shimizu, Nomura, Daniel, Yoshinori Ishikawa, Shimizu, Saki, Vienna Thomas, Shao, Qian, Xavier Tao, Takayuki Inukai   +19 more
core   +1 more source

Gene expression changes in the septum: possible implications for microRNAs in sculpting the maternal brain. [PDF]

PLoS ONE, 2012
The transition from the non-maternal to the maternal state is characterized by a variety of CNS alterations that support the care of offspring. The septum (including lateral and medial portions) is a brain region previously linked to various emotional ...
Changjiu Zhao, Michael C Saul, Terri Driessen, Stephen C Gammie   +3 more
doaj   +1 more source