Results 131 to 140 of about 41,693 (219)

GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC

Eye and Brain, 2023
Guihua Xu, Juanjuan Wang, Yiting Zhang, Zilin Chen, Ruidong Deng Eye Department, Huizhou Municipal Central Hospital, Huizhou, Guangdong, People’s Republic of ChinaCorrespondence: Ruidong Deng; Zilin Chen, Email 359849662@qq.com; boydongdong1@126 ...
Xu G, Wang J, Zhang Y, Chen Z, Deng R
doaj  

Método para reconstrução in silico de redes metabólicas de fungos : um estudo de caso para o Paracoccidioides lutzii [PDF]

, 2014
Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Ciência da Computação, 2014.Os fungos produzem uma variedade de metabólitos com aplicações na indústria e na medicina, ao mesmo tempo que podem ser patógenos ...
Silva, Waldeyr Mendes Cordeiro da
core  

Flavonolignan 2,3-dehydrosilydianin activates Nrf2 and upregulates NAD(P)H:quinone oxidoreductase 1 in Hepa1c1c7 cells [PDF]

, 2017
Silybum marianum (milk thistle) is a medicinal plant used for the treatment of various liver disorders. This study examined whether the main flavonolignans from S. marianum (i.e.
Abenavoli, Albena T. Dinkova-Kostova, Baird, Begum, Biedermann, Biedermann, Bonifaz, Borsari, Chambers, Chow, David Biedermann, Dinkova-Kostova, Dvorak, Dzubak, Fahey, Federico, Feher, Gazak, Gazak, Hayes, Jitka Ulrichová, Jiří Vrba, Krenek, Lenka Roubalová, Liang, Nioi, Prochazkova, Pyszkova, Roubalova, Surai, Tanigawa, Thongphasuk, Trouillas, Varga, Vladimír Křen, Vrba, Wang, Zhan, Zhang, Zhao   +39 more
core   +2 more sources

Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury

Redox Biology
Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translational activation ...
Li-Ping Liang, Ashwini Sri Hari, Brian J. Day, Manisha Patel   +3 more
doaj   +1 more source

Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs

Cellular Physiology and Biochemistry, 2018
Background/Aims: Although red blood cells (RBCs) transfusions can be lifesaving, they are not without risk. RBCs storage is associated with the abnormal metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after ...
Yanlian Xiong, Yanlei Xiong, Yueming Wang, Zhuoya Wang, Aiping Zhang, Nannan Zhao, Dongmei Zhao, Zhenhai Yu, Zhiqiang Wang, Junzhu Yi, Xiying Luan   +10 more
doaj   +1 more source

Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]

, 2016
Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E., Capani, Francisco, Castilla Lozano, Maria del Rocio, Holubiec, Mariana Ines, Logica Tornatore, Tamara Maite Ayelén, Riviere, Stephanie   +5 more
core   +1 more source

Arabidopsis thaliana Glutamate-Cysteine Ligase [PDF]

Journal of Biological Chemistry, 2004
Joseph M. Jez, Rebecca E. Cahoon, Sixue Chen   +2 more
openaire   +1 more source

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape [PDF]

, 2018
Numerous small molecules (termed inducers), many of which are electrophiles, upregulate cytoprotective responses and inhibit pro-inflammatory pathways by activating nuclear factor-erythroid 2 p45-related factor 2 (NRF2).
A Cleasby, A Cuadrado, A Kobayashi, AI Rojo, AL Levonen, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, AT Dinkova-Kostova, C Huerta, D Olagnier, DD Zhang, DD Zhang, E Chan, EH Kobayashi, EL Mills, EV Knatko, EV Knatko, FG Favaloro Jr, H Liu, HJ Prochaska, I Almazari, I Pitha-Rowe, J Alam, JD Hayes, K Itoh, K Itoh, K Liby, K Takaya, M Hayashi, M McMahon, MM Yore, N Suh, N Wakabayashi, P Rada, P Rada, P Talalay, R Saito, RK Thimmulappa, RS Sharma, RV Bensasson, RV Kostov, S Chowdhry, S Chowdhry, S Zheng, SB Cullinan, T Honda, T Honda, T Honda, T Honda, T Honda, T Prestera, T Shekh-Ahmad, T Suzuki, T Yamamoto, TW Kensler, V Duplan, V Sihvola, W Li, W Li, W Yao   +61 more
core   +3 more sources

Wogonoside Modulates the Nrf2/SLC40A1 Signaling Axis to Combat Inflammatory Osteolysis

Food Frontiers, Volume 7, Issue 2, March 2026.
This study explores the potential of wogonoside, a flavonoid from Scutellaria baicalensis, for treating inflammatory osteolysis and provides compelling experimental evidence supporting its promise as a functional food ingredient to alleviate associated bone loss.
Siyuan Zhou, Haoyu Lian, Yuangang Su, Li Wang, Jiake Xu, Jinmin Zhao, Qian Liu   +6 more
wiley   +1 more source