Results 131 to 140 of about 41,955 (229)

Chronic exposure to simulated space conditions predominantly affects cytoskeleton remodeling and oxidative stress response in mouse fetal fibroblasts [PDF]

, 2014
Microgravity and cosmic rays as found in space are difficult to recreate on earth. However, ground-based models exist to simulate space flight experiments.
Abou-El-Ardat, Khalil, Baatout, Sarah, Beck, Michaël, De Vos, Winnok, El-Saghire, Hussein, Janssen, Ann, Michaux, Arlette, Moreels, Marjan, Neefs, Mieke, Quintens, Roel, Tabury, Kevin, Van Oostveldt, Patric   +11 more
core   +2 more sources

Coenzyme A mitigates cystine‐deprivation‐induced ferroptosis by suppressing the iron‐starvation response

The FEBS Journal, EarlyView.
Cystine (Cys2) deprivation in pancreatic cancer cells induces oxidative stress that destabilizes cytosolic iron–sulfur cluster (ISC) proteins, triggering an iron‐regulatory protein (IRP)‐mediated iron‐starvation response (ISR). This leads to increased iron uptake (via TFRC), an expanded labile iron pool, and ferroptosis.
Mingjun Tan, Yunzhan Li, Lei Sang, Min Wang, Qin Li, Zekun Li, Dongxiao Sun, Xiuchao Wang, Shengyu Yang   +8 more
wiley   +1 more source

Astaxanthin attenuates AFB1-induced hepatotoxicity by activating Nrf2 and inhibiting the NF-κB signaling pathway

Ecotoxicology and Environmental Safety
Aflatoxin B1 (AFB1)-induced hepatotoxicity is a common toxic disease in poultry farming. However, there is currently a lack of effective pharmaceutical interventions for treating AFB1.
Kai Kang, Yueying Zhang, Weitian Xie, Wenao Ma, Jinjun Chen, Zhibao Chen   +5 more
doaj   +1 more source

GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC

Eye and Brain, 2023
Guihua Xu, Juanjuan Wang, Yiting Zhang, Zilin Chen, Ruidong Deng Eye Department, Huizhou Municipal Central Hospital, Huizhou, Guangdong, People’s Republic of ChinaCorrespondence: Ruidong Deng; Zilin Chen, Email 359849662@qq.com; boydongdong1@126 ...
Xu G, Wang J, Zhang Y, Chen Z, Deng R
doaj  

Analysis of cellular responses of macrophages to zinc ions and zinc oxide nanoparticles: a combined targeted and proteomic approach [PDF]

, 2014
Two different zinc oxide nanoparticles, as well as zinc ions, are used to study the cellular responses of the RAW 264 macrophage cell line. A proteomic screen is used to provide a wide view of the molecular effects of zinc, and the most prominent results
Armand, Lucie, Aude-Garcia, Catherine, Carrière, Marie, Collin-Faure, Véronique, Diemer, Hélène, Gerdil, Adèle, Habert, Aurélie, Hanau, Daniel, Herlin, Nathalie, Proamer, Fabienne, Rabilloud, Thierry, Strub, Jean-Marc, Triboulet, Sarah, Van Dorsselaer, Alain   +13 more
core   +4 more sources

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury

Redox Biology
Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translational activation ...
Li-Ping Liang, Ashwini Sri Hari, Brian J. Day, Manisha Patel   +3 more
doaj   +1 more source

Inhibition of Glutathione Synthesis via Decreased Glucose Metabolism in Stored RBCs

Cellular Physiology and Biochemistry, 2018
Background/Aims: Although red blood cells (RBCs) transfusions can be lifesaving, they are not without risk. RBCs storage is associated with the abnormal metabolism of glutathione (GSH), which may increase the risk of the oxidative damage of RBCs after ...
Yanlian Xiong, Yanlei Xiong, Yueming Wang, Zhuoya Wang, Aiping Zhang, Nannan Zhao, Dongmei Zhao, Zhenhai Yu, Zhiqiang Wang, Junzhu Yi, Xiying Luan   +10 more
doaj   +1 more source

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. [PDF]

, 2017
Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol and toxin metabolism by catalyzing the conversion of substrates into more polar metabolites and producing reactive oxygen species.
Brenner, David A, Davidson, Nicholas O, Dennis, Edward A, Hu, Ronglin, Karin, Gabriel, Kisseleva, Tatiana, Koyama, Yukinori, Liang, Shuang, Ma, Hsiao-Yen, Quehenberger, Oswald, Sun, Mengxi, Xu, Jun   +11 more
core   +1 more source

Arabidopsis thaliana Glutamate-Cysteine Ligase [PDF]

Journal of Biological Chemistry, 2004
Joseph M. Jez, Rebecca E. Cahoon, Sixue Chen   +2 more
openaire   +1 more source