Results 211 to 220 of about 41,955 (229)

Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)

Phytotherapy Research, 2007
AbstractThe extract of Ginkgo biloba (EGb), containing 24% flavone glycosides and 6% terpenoids, is widely used to treat early‐stage Alzheimer's disease, vascular dementia, peripheral claudication and vascular tinnitus. Its marked antioxidant activity has recently been demonstrated in both cell lines and animals.
Xiao-Ping, Liu, Christopher E P, Goldring, Hai-Yi, Wang, Ian M, Copple, Neil R, Kitteringham, B Kevin, Park, Wei, Wei   +6 more
openaire   +2 more sources

Glutamate Cysteine Ligase (GCL) Transgenic and Gene‐Targeted Mice for Controlling Glutathione Synthesis

Current Protocols in Toxicology, 2009
AbstractThe tripeptide glutathione (GSH) has important antioxidant properties, scavenges free radicals, and serves as a cofactor for glutathione S‐transferase conjugation of many xenobiotics. GSH is synthesized in two steps. The first and, often, rate‐limiting step is the formation of γ‐glutamylcysteine, which is catalyzed by the inducible ...
Isaac, Mohar, Dianne, Botta, Collin C, White, Lisa A, McConnachie, Terrance J, Kavanagh   +4 more
openaire   +2 more sources

Modulating Longevity in Drosophila by Over‐ and Underexpression of Glutamate‐Cysteine Ligase

Annals of the New York Academy of Sciences, 2007
Abstract:  A notable extension of life span (up to 50%) was achieved in Drosophila melanogaster when the catalytic subunit of glutamate‐cysteine ligase (GCLc) was overexpressed in neuronal tissue, while a moderate increase (up to 24%) was observed when the modulatory subunit of GCL (GCLm) was overexpressed globally.
James M, Luchak, Leena, Prabhudesai, Rajindar S, Sohal, Svetlana N, Radyuk, William C, Orr   +4 more
openaire   +2 more sources

Glutamate-Cysteine Ligase Catalytic Subunit

2020
openaire   +1 more source

Glutamate-Cysteine Ligase Regulatory Subunit

2020
openaire   +1 more source

Glutamate-Cysteine Ligase Modifier Knockout Mice

Science of Aging Knowledge Environment, 2002
openaire   +1 more source

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

Molecular Aspects of Medicine, 2009
Donald S. Backos, Henry Jay Forman, Terrance J Kavanagh   +2 more
exaly  

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

Redox Report, 2007
Henry Jay Forman
exaly  

Glutamate-Cysteine Ligase Modifier Subunit Overexpression Confers Resistance Against Busulfan

2020
Gumrukcu, Serhat, Musikanth, Phillip A, Nguyen, Tung   +2 more
openaire   +1 more source

Posttranslational modification and regulation of glutamate–cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

Free Radical Biology and Medicine, 2011
Donald S. Backos, Kristofer S Fritz, James R Roede   +2 more
exaly