Results 141 to 150 of about 898,814 (388)
Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Excitatory synapses convert presynaptic action potentials into chemical signals that are sensed by postsynaptic glutamate receptors. To eavesdrop on synaptic transmission, genetically encoded fluorescent sensors for glutamate have been ...
N. Helassa +9 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Thermoelectric temperature sensors are developed that directly measure heat changes during optical‐based neural stimulation with millisecond precision. The sensors reveal the temperature windows for safe reversible neural modulation: 1.4–4.5 °C enables reversible neural inhibition, while temperatures above 6.1 °C cause permanent thermal damage.
Junhee Lee +9 more
wiley +1 more source
Enhanced production of gamma-aminobutyrate (GABA) in recombinant Corynebacterium glutamicum by expressing glutamate decarboxylase active in expanded pH range [PDF]
, 2015 Jae Woong Choi +5 more
openalex +1 more source
Decreased MK-801 Binding in Discrete Hippocampal Regions of Prion-Infected Mice
Neurobiology of Disease, 2001 The neurochemical alterations associated with neurodegeneration in prion diseases are not well defined. It is therefore of interest to study the influence of prion infection on messenger molecules and their receptors.
M. Diez +4 more
doaj +1 more source
Advanced Functional Materials, EarlyView.The article presents nanomaterial‐integrated fiber neural probes as innovative tools for deep brain molecular sensing, neural stimulation, and temperature monitoring. It examines breakthroughs in SERS‐based biomolecule detection, thermoplasmonic activation, and luminescent thermometry, alongside strategies to overcome stability, specificity, and ...
Di Zheng +5 more
wiley +1 more source
Depolarization-Induced 65Zinc Influx into Cultured Cortical Neurons
Neurobiology of Disease, 2002 Toxic Zn2+ influx may be a key mechanism underlying selective neuronal death after transient global ischemia in rats. To identify routes responsible for neuronal Zn2+ influx, we measured the accumulation of 65Zn2+ into cultured murine cortical cells ...
Christian T. Sheline +4 more
doaj +1 more source
Glutamate as a neurotransmitter in the healthy brain
Journal of neural transmission, 2014 Glutamate is the most abundant free amino acid in the brain and is at the crossroad between multiple metabolic pathways. Considering this, it was a surprise to discover that glutamate has excitatory effects on nerve cells, and that it can excite cells to
Yun Zhou, N. Danbolt
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel +6 more
wiley +1 more source
The unique invasiveness of glioblastoma and possible drug targets on extracellular matrix
Cancer Management and Research, 2019 Adam Hatoum,1 Raihan Mohammed,1 Omar Zakieh2 1School of Clinical Medicine, University of Cambridge, Cambridge, UK; 2Faculty of Medicine, Imperial College London, London, UK Abstract: Glioblastoma, or glioblastoma multiforme (GBM), is described as ...
Hatoum A, Mohammed R, Zakieh O
doaj
The glutathione cycle shapes synaptic glutamate activity
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Glutathione is a major antioxidant and redox regulator in cells. In addition to its essential roles in redox homeostasis, it functions as cofactors for a multitude of enzymes.
T. Sedlak +8 more
semanticscholar +1 more source