Results 131 to 140 of about 662,038 (354)
Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]
, 2012 Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna +17 more
core +1 more source
Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery
Advanced Functional Materials, EarlyView.This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar +4 more
wiley +1 more source
Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity [PDF]
, 2003 A reduction in microglial activation and subsequent neurotoxicity may prove critical for neuroprotection in neurodegenerative diseases. We examined the expression and functionality of group III metabotropic glutamate (mGlu) receptors on microglia.
Taylor, D.L., Pocock, J.M., Diemel, L.T.
core
Regulation of Arabidopsis 14-3-3 gene expression by GABA. [PDF]
, 2006 The function in plants of the non-protein amino acid, gamma-aminobutyric acid (GABA) is poorly understood. In this study, we show that GABA down-regulates the expression of a large sub-set of 14-3-3 gene family members in Arabidopsis thaliana seedlings ...
Lancien, Muriel +3 more
core +1 more source
Dynamic Network Connectivity: from monkeys to humans
Frontiers in Human NeuroscienceHuman brain imaging research using functional MRI (fMRI) has uncovered flexible variations in the functional connectivity between brain regions. While some of this variability likely arises from the pattern of information flow through circuits, it may ...
Amy F. T. Arnsten +2 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco +7 more
wiley +1 more source
Plants, 2016 In the context of climatic change, more heavy precipitation and more frequent flooding and waterlogging events threaten the productivity of arable farmland.
Houssein Diab, Anis M. Limami
doaj +1 more source
Advanced Materials, EarlyView.Clinically, intermittent hypoxia (IH) is often accompanied by periodontitis, which accelerates cognitive impairment induced by IH. Novel Janus mesoporous gold‐silica nanoformulations (RVG‐Au&mSiO2‐TPP‐VB) enable intranasal delivery, achieve hierarchical targeting to neuronal mitochondria, effectively scavenge reactive oxygen species, inhibit the HIF‐1α/
Kai‐Run Zhang +15 more
wiley +1 more source
Prevalence of autoantibodies to the 65- and 67-kD isoforms of glutamate decarboxylase in insulin-dependent diabetes mellitus [PDF]
, 1993 We investigated the presence of autoantibodies to baculovirus-expressed human recombinant 65- and 67-kD isoforms of glutamate decarboxylase (GAD65 and GAD67) in insulin-dependent diabetes mellitus (IDDM).
Haubruck, Heinz +20 more
core +1 more source
Gut microbiota and stress ulcers: unraveling the neurotransmitter connection
Frontiers in NeuroscienceBackgroundNeurotransmitters are key signaling molecules in the brain-gut axis, may be involved in stress-induced ulcer damage.ObjectiveThis study aims to address the relationship between gut microbiota and the stress response is examined in this review ...
Khaled A. Abdel-Sater, Heba A. Hassan
doaj +1 more source