Results 141 to 150 of about 662,038 (354)
Advanced Materials, EarlyView.Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi +3 more
wiley +1 more source
Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]
, 2011 Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana +11 more
core +1 more source
Glutamate and dopamine in schizophrenia: an update for the 21st century
Journal of Psychopharmacology, 2015 The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of schizophrenia. Both were initially based on indirect evidence from pharmacological studies supported by post-mortem findings, but have since been substantially advanced ...
O. Howes, R. McCutcheon, J. Stone
semanticscholar +1 more source
Advanced Materials Interfaces, EarlyView.PEG‐guided mitochondrial surface engineering supports structural stabilization and controlled presentation of cell‐penetrating peptides. CPP–PEG‐modified mitochondria exhibit enhanced cellular uptake and uptake‐associated respiratory modulation, providing a proof‐of‐concept framework for modular organelle engineering and future bioenergetic modulation ...
Masahiro Shiraishi +9 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2017 Excitatory amino acid transporters (EAATs) are secondary active transporters of L-glutamate and L- or D-aspartate. These carriers also mediate a thermodynamically uncoupled anion conductance that is gated by Na+ and substrate binding.
Christopher B. Divito +6 more
doaj +1 more source
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila
Cell, 2009 Summary Ionotropic glutamate receptors (iGluRs) mediate neuronal communication at synapses throughout vertebrate and invertebrate nervous systems.
R. Benton +3 more
semanticscholar +1 more source
MANGO‐“Fruitcage”: A Conditional Photocage Utilizing a Fluorescence Light‐Up Aptamer
Advanced Optical Materials, EarlyView.Fruitcaging ‐ a proof of concept study of a conditional photocage (Thiazol‐Orange) activated upon binding to the fluorescence light up aptamer (Mango). The prolongation of the excited state lifetime explains the redirection of the reactive pathway toward photocleavage and provides a sensitive spectroscopic readout.
Konstantinos Stamatakis +6 more
wiley +1 more source
Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived fas ligand [PDF]
, 2005 Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic benefit.
Taylor, DL +3 more
core
Counting the Number of Glutamate Molecules in Single Synaptic Vesicles [PDF]
, 2019 Analytical tools for direct quantitative measurements of glutamate, the principal excitatory neurotransmitter in brain, are lacking. Here, we introduce a new enzyme-based amperometric sensor technique for direct counting of the number of glutamate ...
Hoda, fathali +6 more
core +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source