Results 161 to 170 of about 732,660 (295)

Changing hydration level in an internal cavity modulates the proton affinity of a key glutamate in cytochromecoxidase [PDF]

, 2013
Puja Goyal, Jianxun Lu, Shuo Yang, M. R. Gunner, Qiang Cui   +4 more
openalex   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Distribution of glutamate receptor subtypes in the vertebrate retina

, 1995
Yuandong Peng, Craig Blackstone, Richard L. Huganir, King‐Wai Yau   +3 more
openalex   +1 more source

PRDM16 Reduces Cellular Senescence by Upregulating GSTM1

Advanced Science, EarlyView.
Cellular senescence drives aging and aging‐related organ disorders, yet PRDM16's role remains unexplored. This work uncovers that PRDM16 decreases significantly in aged organs, while its loss accelerates cellular senescence and aging‐related organ injury.
Qian Yuan, Yuting Zhu, Ben Tang, Yaru Xie, Mingcun Hu, Hua Su, Youhua Liu, Chun Zhang   +7 more
wiley   +1 more source

Glutamate Uptake Is Not Impaired by Hypoxia in a Culture Model of Human Fetal Neural Stem Cell-Derived Astrocytes [PDF]

, 2022
Vadanya Shrivastava, Devanjan Dey, Chitra Mohinder Singh Singal, Paritosh Jaiswal, Ankit Singh, Jai Bhagwan Sharma, Parthaprasad Chattopadhyay, Nihar R. Nayak, Jayanth Kumar Palanichamy, Subrata Sinha, Pankaj Seth, Sudip Sen   +11 more
openalex   +1 more source

Effect of Additional Terminal Residues on the Folding and Unfolding Dynamics of Cold Shock Protein

Advanced Science, EarlyView.
Enhancing protein stability through N‐ and C‐terminal modifications presents a safe and cost‐effective strategy. We investigated this by combining single‐molecule magnetic tweezers experiments and molecular dynamics simulations to study the folding and unfolding dynamics of CSP with various appended residues (LE‐CSP‐GS, KL‐CSP‐GS, KL‐CSP‐LE).
Dan Hu, Yang Wang, Huanjie Jiang, Hai Pan, Yunqiang Bian, Weitong Ren, Hu Chen, Zilong Guo, Yanwei Wang   +8 more
wiley   +1 more source

Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions

Advanced Science, EarlyView.
Transition metals trigger distinct regulated cell death pathways beyond traditional apoptosis. This review examines ferroptosis (iron‐catalyzed lipid peroxidation) and cuproptosis (copper‐induced mitochondrial proteotoxicity), while exploring hypothetical “cobaltosis” as a novel pathway.
Qinghang Song, Yuxuan Yang, Lina Yang
wiley   +1 more source

Glutamate in unusual places

, 2003
Nicole LeBrasseur, Nicole LeBrasseur
openalex   +1 more source

Phorbol Myristate Acetate-Dependent Interaction of Protein Kinase Cα and the Neuronal Glutamate Transporter EAAC1 [PDF]

, 2003
Marco I. González, Peter Bannerman, Michael B. Robinson   +2 more
openalex   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

Advanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang, Qinyu Li, Zijie Li, Xuejiao Wang, Hui Yuan, Pingting Yang, Ling Qin   +6 more
wiley   +1 more source