Results 181 to 190 of about 898,814 (388)
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Editorial: The known, the unknown, and the future of glutamate transporters
Frontiers in Cellular Neuroscience, 2022 Zila Martinez-Lozada +4 more
doaj +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury
, 2018 Amber W. Wang +6 more
openalex +2 more sources
Anatomy and Function of Ventral Tegmental Area Glutamate Neurons [PDF]
, 2022 Jing Cai, Qingchun Tong
openalex +1 more source
Advanced Science, EarlyView.Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li +13 more
wiley +1 more source
Trifluoperazine and dibucaine‐induced inhibition of glutamate‐induced mitochondrial depolarization in rat cultured forebrain neurones [PDF]
, 1997 Kari R. Hoyt +2 more
openalex +1 more source
Regulation of Glutamate, GABA and Dopamine Transporter Uptake, Surface Mobility and Expression [PDF]
, 2021 Renae M. Ryan +2 more
openalex +1 more source
Advanced Science, EarlyView.Psychological stress activates the sympathetic–adrenal axis, elevating norepinephrine (NE) and suppressing reproductive hormones, thereby impairing male reproduction. Excess NE overactivates and desensitizes β‐adrenergic receptors (β‐ARs), triggering Sertoli cell ferroptosis and disrupting spermatogenesis.
Lingyu Zhang +12 more
wiley +1 more source