Results 181 to 190 of about 732,660 (295)

Myocardial protection by acidic amino acids and natural dipeptides: potential for an underused resource. [PDF]

Amino Acids
King N.
europepmc   +1 more source

eIF4E Enriched Extracellular Vesicles Induce Immunosuppressive Macrophages through HMGCR‐Mediated Metabolic Rewiring

Advanced Science, EarlyView.
Here, it is revealed that ovarian cancer cells release extracellular vesicles enriched with eIF4E, which alters protein production in macrophages. This leads to increased expression of 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase (HMGCR), boosting cholesterol synthesis and activating an immunosuppressive pathway through X‐box binding protein 1 and ...
Sonam Mittal, Minal Nenwani, Ishaque Pulikkal Kadamberi, Sudhir Kumar, Olamide Animasahun, Jasmine George, Shirng‐Wern Tsaih, Prachi Gupta, Mona Singh, Anjali Geethadevi, Chandrima Dey, Noah Meurs, Ajay Shankaran, Pradeep Chaluvally Raghavan, Deepak Nagrath, Sunila Pradeep   +15 more
wiley   +1 more source

Modulatory effects of GLT-1 enhancer, MC-100093, on glutamate uptake and associated signaling pathways in female and male alcohol preferring rats exposed to ethanol. [PDF]

Int J Neuropsychopharmacol
Alotaibi A, Bhowmik KK, Wong W, Mohammed AS, Abou-Gharbia M, Childers W, Sari Y.   +6 more
europepmc   +1 more source

Facilitation of glutamate receptors reverses an age-associated memory impairment in rats [PDF]

, 1996
Richard Granger, Sam A. Deadwyler, Mike Davis, Brian Moskovitz, Markus Kessler, Gary A. Rogers, Gary Lynch   +6 more
openalex   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Glutamate decreases oxidative stress and lipid droplet formation in astrocytes. [PDF]

J Cell Sci
Rubio-Atonal LF, Chang J, Jacquemyn J, Ralhan I, Ilarraza I, Ioannou MS.   +5 more
europepmc   +1 more source

Dual‐Emission Carbon Dot Nanozymes Mitigate Salt Stress and Enhance Photosynthesis for Crop Germination and Growth

Advanced Science, EarlyView.
Dual‐emission carbon dot nanozymes are synthesized via microwave method. The nanozymes enhance photosynthesis corn seedlings through spectral‐matched light conversion. Their superoxide dismutase‐mimetic activity scavenges salt stress‐induced reactive oxygen species and circumvents energy‐intensive stress responses.
Chengfu Su, Xin Peng, Jingying Tan, Yujie Chang, Naifei Pan, Haiying Chen, Xiaokai Xu, Lei Han   +7 more
wiley   +1 more source

The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia. [PDF]

Front Cardiovasc Med
Wang R, Yuan X, Xie T, Zhao X, Li J, Zhang X, Lv C.   +6 more
europepmc   +1 more source

A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate

Advanced Science, EarlyView.
Here, a genetically encoded glutarate biosensor, Glusor, is developed based on transcriptional regulator CsiR. Glusor can quantify glutarate concentrations with good accuracy and precision. Then, the role of KgtP and YnfM are identified and characterized by using Glusor. Glusor also allows glutarate spatiotemporal resolution in live cells, facilitating
Kaiyu Gao, Hui Zhang, Yidong Liu, Xianzhi Xu, Wei Liu, Zhaoqi Kang, Rong Xu, Shuang Hou, Ping Han, Chuanjuan Lü, Cuiqing Ma, Ping Xu, Chao Gao   +12 more
wiley   +1 more source

Ceftriaxone suppresses the severity of paclitaxel-induced glutamate-mediated chronic pain in experimental animals. [PDF]

Sci Rep
Taspinar N, Hacimuftuoglu A, Binnetoglu D, Kocpinar EF, Baltaci NG, Budak H, Abd El-Aty AM.   +6 more
europepmc   +1 more source