Results 191 to 200 of about 716,780 (343)

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

MGlu5 Dependent Mitochondrial Translocation of PKCδ: A Mechanism Raising Astrocytic Oxidative Metabolism in Response to Extracellular Glutamate. [PDF]

J Neurochem
Farid KMN, Lerchundi R, Rose CR, Derouiche A.   +3 more
europepmc   +1 more source

Piezoelectric Effect in Poly-γ-methyl-L-glutamate [PDF]

, 1966
Eiichi Fukada, Munehiro Date, Nobuyuki Hirai   +2 more
openalex   +1 more source

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Effects of Micro-injections of L-Glutamate into the Hypothalamus on Attack and Flight Behaviour in Cats [PDF]

, 1969
Jill Brody, P. A. Defeudis, F.V. DeFeudis   +2 more
openalex   +1 more source

The Interplay between the Gut and Ketogenic Diets in Health and Disease

Advanced Science, EarlyView.
This review synthesizes current knowledge on the interaction between ketogenic diets and the gut, covering gut physiology, intestinal immunity, and the gut microbiome. It explores innovative methods for tailoring the diet to maximize benefits while reducing side effects. Emphasis is placed on gut‐mediated mechanisms as a critical interface between diet
Chunlong Mu, Jong M. Rho, Jane Shearer
wiley   +1 more source

<i>gltB</i> encoding glutamate synthase is involved in persister and biofilm formation and virulence in <i>Staphylococcus aureus</i>. [PDF]

Microbiol Spectr
Wen X, Tang T, Bao T, Xu T, An B, Zhang Y, Han J.   +6 more
europepmc   +1 more source

Desensitization of glutamate dehydrogenase by reaction of tyrosine residues [PDF]

, 1969
Nicholas C. Price, G. K. Radda
openalex   +1 more source

A Longitudinal Study Reveals Metabolomic Markers for Individuals at Risk, Disease Severity, and Treatment Response in Rheumatoid Arthritis

Advanced Science, EarlyView.
This study investigates plasma metabolomic biomarkers for rheumatoid arthritis (RA) development using longitudinal data from 209 RA patients and 56 individuals at risk. It also reveals metabolic signatures linked to severity, age, sex, and anti‐citrullinated protein autoantibody in RA.
Chenxi Zhu, Jiayi Xu, Siyu He, Qian Niu, Yi Liu, Xin Guo, Huifang Hu, Rui Sun, Tao Chen, Yan Liu, Zhiqiang Xu, Na Jiang, Lipu Yao, Lunzhi Dai, Qinghua Zou, Fanxin Zeng, Liesu Meng, Inger Gjertsson, Rikard Holmdahl, Bin Yang, Dan Du, Yi Zhao   +21 more
wiley   +1 more source

The Need for Uniform Labeling Regulations for Monosodium Glutamate to Address Health Risks and Consumer Protection. [PDF]

Cureus
Purvez A, Valentine MC.
europepmc   +1 more source