Results 191 to 200 of about 898,814 (388)

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Ripa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma [PDF]

Lemeng Feng, Shirui Dai, Cheng Zhang, Wulong Zhang, Weiming Zhu, Chao Wang, Ye He, Weitao Song   +7 more
openalex   +1 more source

Glutamate Cysteine Ligase—Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage [PDF]

, 2016
Suzie Lavoie, Pascal Steullet, Anita Kulak, Frédéric Preitner, Kim Q., Pierre J. Magistretti   +5 more
openalex   +1 more source

Brain pericytes increase sodium-dependent glutamate uptake in astrocytes.

, 2021
Fuyuko Takata, Kenta Sakai, Takuro Iwao, Junichi Matsumoto, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohgu   +6 more
openalex   +2 more sources

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

Neuron, 1996
J. Rothstein, M. Dykes‐Hoberg, C. Pardo, L. Bristol, Lin Jin, R. Kuncl, Y. Kanai, M. Hediger, Yanfeng Wang, Jerry P Schielke, D. Welty   +10 more
semanticscholar   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Targeting Adipose Tissue Function Protects Against Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
This study explores the role adipose tissue (AT) phenotypes have in determining cardiovascular outcomes in an obesity‐related heart failure with preserved ejection fraction (HFpEF) model. Pharmacological induction of thermogenesis promoted resilience to HFpEF‐induced remodeling of AT and conferred cardioprotection. Surgical and genetic models confirmed
Jordan Jousma, Zhenbo Han, Jooman Park, Gege Yan, Sen Zhang, Youjeong Kwon, Sarath Babu Nukala, Jindpreet Kandola, Sandra Pinho, Chong Wee Liew, Yuwei Jiang, Sang‐Ging Ong   +11 more
wiley   +1 more source

Effects of intra-accumbal administration of dopamine and ionotropic glutamate receptor drugs on delay discounting performance in rats.

, 2017
Justin R. Yates, Michael T. Bardo
openalex   +1 more source

Ameliorative potentials of methanol leaf extract of Newbouldia laevis on monosodium glutamate induced toxicity in female albino rats

, 2020
Itez Paul, Aloh Godwin S, Osuocha Kelechi U, Iwueke Adaku, C. Ezinne Chukwu   +4 more
openalex   +1 more source

198. In Vitro and In Vivo Gene-Transferring Characteristics of Novel Cationic Lipids, DMKD(O,O′-dimyristyl-N-lysyl aspartate) and DMKE(O,O′-dimyristyl-N-lysyl Glutamate) [PDF]

, 2006
Hong Sung Kim, In Ho Song, Jong Chul Kim, Eun‐Jung Kim, Yeon Kyung Lee, Jung Seok Kim, Kyung Hye Koo, Doo Ok Jang, Yong Serk Park   +8 more
openalex   +1 more source