Results 241 to 250 of about 585,844 (339)

VGLUT2 in Parkinson's disease: an emerging therapeutic target. [PDF]

Expert Opin Ther Targets
Freyberg Z, Torregrossa MM, Rocha EM.
europepmc   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

CB1 Receptor Activation Provides Neuroprotection in an Animal Model of Glutamate‐Induced Excitotoxicity Through a Reduction of NOX‐2 Activity and Oxidative Stress

Ataúlfo Martı́nez-Torres, Julio Morán   +1 more
openalex   +1 more source

Pharmacological analysis on the rise of the nuclear calcium by glutamate and its role in neuronal cell death

, 2000
Kohtaro Kato, Jie Li, Jun-iti Ikeda, Ikuo Morita, Sei‐itsu Murota   +4 more
openalex   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Endothelium glutamate receptors in brain pathology. [PDF]

Front Pharmacol
Pirozhkov SV, Vukolova MN, Bulgakova VV, Lutokhina YA, Bolevich SB, Sobolevsky AI, Yelshanskaya MV.   +6 more
europepmc   +1 more source

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

, 2008
P. Jeffrey Conn, Craig W. Lindsley, Carrie K. Jones   +2 more
openalex   +1 more source

Competition Between Liquid‐Liquid Crystalline Phase Separation (LLCPS) and Liquid‐Liquid Phase Separation (LLPS) in Amyloid Fibril Colloidal Systems

Advanced Science, EarlyView.
This study shows that amyloid fibrils form nematic condensates via liquid–liquid crystalline phase separation (LLCPS). With increasing pH, this transition shifts toward disordered condensates formed through liquid–liquid phase separation (LLPS), in which birefringence with lack of a coherent nematic field symmetry originates from enthalpic fibril ...
Milad Radiom, Raffaele Mezzenga
wiley   +1 more source

Acute Intravenous Astaxanthin Administration Modulates Hyperexcitability in Rat Nociceptive Secondary Sensory Neurons Induced by Inflammation. [PDF]

Mar Drugs
Chida R, Takeda M.
europepmc   +1 more source

Glutamate metabolism and HIV-associated neurocognitive disorders

, 2014
Fabián J Vázquez-Santiago, Richard J. Noel, James T. Porter, Vanessa Rivera‐Amill   +3 more
openalex   +2 more sources