Results 131 to 140 of about 228,854 (227)

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

open access: yesFood Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech   +8 more
wiley   +1 more source

Cannabinoid Receptor Type 1 Regulates Drug Reward Behavior via Glutamate Decarboxylase 67 Transcription. [PDF]

open access: yesInt J Mol Sci, 2021
Gu SM   +10 more
europepmc   +1 more source

Substrate specificity of a ketosynthase domain involved in bacillaene biosynthesis

open access: yesBeilstein Journal of Organic Chemistry
An isotopic labelling method was developed to investigate substrate binding by ketosynthases, exemplified by the second ketosynthase of the polyketide synthase BaeJ involved in bacillaene biosynthesis (BaeJ-KS2).
Zhiyong Yin, Jeroen S. Dickschat
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo   +11 more
wiley   +1 more source

Oral Supplementation With a Bovine Thymus Extract Reduces Neuronal Excitability in Aging Mice

open access: yesFASEB BioAdvances, Volume 8, Issue 2, February 2026.
Oral supplementation of aging mice with a nuclear fraction extract of bovine thymus (TNF) leads to significant increases in GAD65, GAD67, and β2/β3 subunits of the GABAA receptor, more so with high dose (HD) TNF treatment compared to low dose (LD) and control condition.
Abdeslem El‐Idrissi   +2 more
wiley   +1 more source

Lifespan‐Extending Endogenous Metabolites

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Weak Association Between the Glutamate Decarboxylase 1 Gene (GAD1) and Schizophrenia in Han Chinese Population. [PDF]

open access: yesFront Neurosci, 2021
Zhang L   +14 more
europepmc   +1 more source

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