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Integration of Glutamate Dehydrogenase and Nanoporous Gold for Electrochemical Detection of Glutamate [PDF]
Biosensors, 2023 Glutamate, a non-essential amino acid produced by fermentation, plays a significant role in disease diagnosis and food safety. It is important to enable the real-time monitoring of glutamate concentration for human health and nutrition.
Ting Cai +5 more
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Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment [PDF]
Orphanet Journal of Rare Diseases, 2023 Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration.
Qiao Zeng, Yan-Mei Sang
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Isoenzymes of Glutamate Dehydrogenase in Plants [PDF]
Plant Physiology, 1969 Glutamate dehydrogenase of several different plants was resolved by polyacrylamide gel electrophoresis into separate molecular forms and the isoenzymic patterns detected by the tetrazolium technique were compared. The number of isoenzymes and their electrophoretic mobilities varied among the different plants studied.
Shuang Yue
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Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons [PDF]
Nature Communications, 2021 α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected
Franziska R. Traube +17 more
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Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes
Frontiers in Endocrinology, 2013 We recently found evidence for anatomic and physical linkages between the astroglial Na+-dependent glutamate transporters (GLT-1/EAAT2 and GLAST/EAAT1) and mitochondria.
Brendan S Whitelaw +3 more
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Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
Malaria Journal, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
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Physiological Role of Glutamate Dehydrogenase in Cancer Cells [PDF]
Frontiers in Oncology, 2020 NH4+ increased growth rates and final densities of several human metastatic cancer cells. To assess whether glutamate dehydrogenase (GDH) in cancer cells may catalyze the reverse reaction of NH4+ fixation, its covalent regulation and kinetic parameters ...
Rafael Moreno-Sánchez +7 more
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The role of glutamate dehydrogenase in the ageing brain [PDF]
Frontiers in PharmacologyThe homeostasis of glutamate, the primary excitatory neurotransmitter in the brain and is crucial for normal brain function. The mitochondrial enzyme glutamate dehydrogenase (GDH) connects the multifunctional amino acid glutamate, which is intimately ...
Tao Zhou, Haichuan Wang
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Frontiers in Cell and Developmental Biology, 2023 Glutamate dehydrogenases are enzymes that take part in both amino acid and energy metabolism. Their role is clear in many biological processes, from neuronal function to cancer development. The putative testis-specific Drosophila glutamate dehydrogenase,
Viktor Vedelek +6 more
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A glutamate dehydrogenase gene sequence [PDF]
Nucleic Acids Research, 1989 A Chlorella sorokiniana genomic DNA library was screened with a NADP-specific glutamate dehydrogenase (GDH) cDNA. Two putative GDH sequences were isolated. One sequence is typically eukaryotic in that its coding region is interrupted by many introns (1). Southern blots showed that C.
Cock, J. Mark, Schmidt, Robert
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