Integration of Glutamate Dehydrogenase and Nanoporous Gold for Electrochemical Detection of Glutamate [PDF]
Biosensors, 2023 Glutamate, a non-essential amino acid produced by fermentation, plays a significant role in disease diagnosis and food safety. It is important to enable the real-time monitoring of glutamate concentration for human health and nutrition.
Ting Cai +5 more
doaj +2 more sources
Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment [PDF]
Orphanet Journal of Rare Diseases, 2023 Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration.
Qiao Zeng, Yan-Mei Sang
doaj +2 more sources
Oxoglutarate dehydrogenase complex controls glutamate-mediated neuronal death
Redox Biology, 2023 Brain injury is accompanied by neuroinflammation, accumulation of extracellular glutamate and mitochondrial dysfunction, all of which cause neuronal death. The aim of this study was to investigate the impact of these mechanisms on neuronal death.Patients
Adelheid Weidinger +19 more
doaj +2 more sources
Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons [PDF]
Nature Communications, 2021 α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected
Franziska R. Traube +17 more
doaj +2 more sources
The role of glutamate dehydrogenase in the ageing brain [PDF]
Frontiers in PharmacologyThe homeostasis of glutamate, the primary excitatory neurotransmitter in the brain and is crucial for normal brain function. The mitochondrial enzyme glutamate dehydrogenase (GDH) connects the multifunctional amino acid glutamate, which is intimately ...
Tao Zhou, Haichuan Wang
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Physiological Role of Glutamate Dehydrogenase in Cancer Cells [PDF]
Frontiers in Oncology, 2020 NH4+ increased growth rates and final densities of several human metastatic cancer cells. To assess whether glutamate dehydrogenase (GDH) in cancer cells may catalyze the reverse reaction of NH4+ fixation, its covalent regulation and kinetic parameters ...
Rafael Moreno-Sánchez +7 more
doaj +2 more sources
Serum glutamate dehydrogenase activity enables sensitive and specific diagnosis of hepatocellular injury in humans. [PDF]
Toxicol SciAubrecht J +7 more
europepmc +3 more sources
Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation. [PDF]
J Oncol, 2022 Mao L +8 more
europepmc +3 more sources
Can Macromolecular Crowding Help Regulate Glutamate Dehydrogenase Activity? [PDF]
ACS OmegaGenesis Rosario +8 more
doaj +2 more sources
Glutamate dehydrogenase 2 is required for virulence by facilitating fungal growth in the host hemocoel. [PDF]
VirulenceLu Y +8 more
europepmc +2 more sources