Results 31 to 40 of about 142,175 (352)

Branched‐chain α‐keto acids and glutamate/glutamine: Biomarkers of insulin resistance in childhood obesity

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Insulin resistance (IR) in adolescents with obesity is associated with a sex‐dependent metabolic “signature” comprising the branched‐chain amino acids (BCAAs), glutamate/glutamine, C3/C5 acylcarnitines, and uric acid. Here, we compared the levels of branched‐chain α‐keto acids (BCKAs) and glutamate/glutamine, which are byproducts of BCAA catabolism, as
Pinar Gumus Balikcioglu, Catherine Jachthuber Trub, Metin Balikcioglu, Olga Ilkayeva, Phillip J. White, Michael Muehlbauer, James R. Bain, Sarah Armstrong, Michael Freemark   +8 more
wiley   +1 more source

Filamentous invasive growth of mutants of the genes encoding ammonia-metabolizing enzymes in the fission yeast Schizosaccharomyces pombe. [PDF]

PLoS ONE, 2017
The fission yeast Schizosaccharomyces pombe undergoes a switch from yeast to filamentous invasive growth in response to certain environmental stimuli. Among them is ammonium limitation.
Yoshie Sasaki, Ayumi Kojima, Yuriko Shibata, Hiroshi Mitsuzawa   +3 more
doaj   +1 more source

Molecular mechanisms of adaptation of the moderately halophilic bacterium Halobacillis halophilus to its environment [PDF]

, 2013
The capability of osmoadaptation is a prerequisite of organisms that live in an environment with changing salinities. Halobacillus halophilus is a moderately halophilic bacterium that grows between 0.4 and 3 M NaCl by accumulating both chloride and ...
Hänelt, Inga, Müller, Volker
core   +2 more sources

Differential Levels of Glutamate Dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 Mice and the Effects of Overexpression of the Gene on Glutamate Release in Striatum

ASN Neuro, 2011
We have previously shown that overexpression of the Glud1 (glutamate dehydrogenase 1) gene in neurons of C57BL/6 mice results in increased depolarization-induced glutamate release that eventually leads to selective neuronal injury and cell loss by 12 ...
Kevin N Hascup, Xiaodong Bao, Erin R Hascup, Dongwei Hui, Wenhao Xu, Francois Pomerleau, Peter Huettl, Mary L Michaelis, Elias K Michaelis, Greg A Gerhardt   +9 more
doaj   +1 more source

Platelet glutamate dehydrogenase activity and efficacy of antipsychotic therapy in patients with schizophrenia [PDF]

Journal of Medical Biochemistry, 2020
Background: Evaluation of possible relationship between platelet glutamate dehydrogenase (GDH) activity and mental state of schizophrenia patients after antipsychotic pharmacotherapy. Methods: Patients (n = 50) with chronic paranoid schizophrenia (F20.0)
Savushkina Olga K., Tereshkina Elena B., Prokhorova Tatiana A., Boksha Irina S., Burminskii Denis S., Vorobyeva Elena A., Morozova Margarita A., Burbaeva Gulnur Sh.   +7 more
doaj  

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease [PDF]

, 2009
Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals.
Ara  jo, Ba  os, Cremer, Crome, Daniel, Dhopeshwarkar, Dodd, G. E. Homanics, H. S. Paul, Hariharan, Hauber, Homanics, J. Lazovic, J. M. Flanagan, Jan, K. C. Cheng, K. F. LaNoue, K. Griffin, K. J. Skvorak, Kamei, Killian, Le Masurier, Lowry, Lo  , M. C. Bewley, Mackenzie, McKean, Morton, O'Callaghan, Ouary, Patel, Patel, Regunathan, Schadewaldt, Schmithorst, Schonberger, Sgaravatti, She, SILBERMAN, Simon, Tews, W. J. Zinnanti, Wajner, Williamson, Yudkoff   +44 more
core   +2 more sources

Evaluating and forecasting the associated main flavor components in Baijiu (Chinese distilled spirits) with alcohol metabolism and hangover symptoms through mice acute withdrawal model

Food Science &Nutrition, Volume 11, Issue 1, Page 334-343, January 2023., 2023
Chinese distilled spirits (Baijiu) is one of the most favourite alcohol beverages. The flavor quality of Baijiu is supposed to be one of the key factors which caused the hangover. However, little systematic study has been done to estimate the flavors effects on the hangover in the different aroma‐type of Baijiu.
Jie Huangfu, Jun Lu, Changwen Li, Deliang Wang, Chunguang Luan, Xin Jiang, Tao Song, Wei Jiang, Xinlin Han, Jing Feng, Yanli Liu, Mengchao He   +11 more
wiley   +1 more source

METABOLIC PLATELET STATUS IN PATIENTS WITH STABLE ANGINA

Российский кардиологический журнал, 2013
Aim. To study the activity of NAD- and NADP-dependent platelet dehydrogenases in patients with various functional classes of angina. Material and methods. The study included 91 men with Functional Class II–IV angina, aged 45–72 years. In all participants,
I. Yu. Grinstein, A. A. Savchenko, E. A. Savchenko, A. A. Kosinova, Yu. I. Grinstein   +4 more
doaj   +1 more source

Gray and white matter astrocytes differ in basal metabolism but respond similarly to neuronal activity

Glia, Volume 71, Issue 2, Page 229-244, February 2023., 2023
Main Points Gray and white matter astrocytes have different basal NADH/NAD+ redox states and ATP levels. Metabolism of both cell populations responds similarly to neuronal activity. Glutamate induced ATP loss is prevented by increasing extracellular K+.
Susanne Köhler, Ulrike Winkler, Tabea Junge, Kristina Lippmann, Jens Eilers, Johannes Hirrlinger   +5 more
wiley   +1 more source

Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain

Biomolecules, 2016
Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a
Arthur J. L. Cooper, Thomas M. Jeitner
doaj   +1 more source