Results 41 to 50 of about 88,094 (191)

Adjunctive perampanel for glioma-associated epilepsy

Epilepsy and Behavior Case Reports, 2018
Glioma-associated epilepsy is associated with excessive glutamate signaling. We hypothesized that perampanel, an amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor antagonist, would treat glioma-related epilepsy.
Anastasie M. Dunn-Pirio, Sarah Woodring, Eric Lipp, James E. Herndon, II, Patrick Healy, Mallika Weant, Dina Randazzo, Annick Desjardins, Henry S. Friedman, Katherine B. Peters   +9 more
doaj   +1 more source

L-Glutamate Dehydrogenase Isoenzymes [PDF]

Nature, 1962
SEVERAL dehydrogenases have been resolved into isoenzymes by electrophoresis in starch gel. Attempts to fractionate L-glutamate dehydrogenase in this way, however, have so far failed. Markert and Moller1 found that this enzyme was electrophoretically immobile in starch gel, and Tsao2 obtained negative results in attempts to fractionate and render gluta-
openaire   +3 more sources

L-leucine stimulates glutamate dehydrogenase activity and glutamate synthesis by regulating mTORC1/SIRT4 pathway in pig liver

Animal Nutrition, 2018
The liver is the most essential organ for the metabolism of ammonia, in where most of ammonia is removed by urea and glutamine synthesis. Regulated by leucine, glutamate dehydrogenase (GDH) catalyzes the reversible inter-conversion of glutamate to ...
Tongxin Wang, Weilei Yao, Qiongyu He, Yafei Shao, Ruilong Zheng, Feiruo Huang   +5 more
doaj   +1 more source

Isoenzyme pattern of glutamate dehydrogenase as a reflection of nitrogen metabolism in Lupinus albus

Acta Societatis Botanicorum Poloniae, 2015
Glutamate dehydrogenase (L-glutamate: NAD dehydrogenase, EC 1.4. 1.2; GDH) activity and electrophoretic separation pattern of the enzyme were studied. The enzyme was extracted from embryos of Lupinus albus decotyledonized and cultured for 24, 48 and 72 ...
Lech Ratajczak, Wiktoria Ratajczak, Hanna Mazurowa   +2 more
doaj   +1 more source

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution

Cell Reports, 2015
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain.
Melis Karaca, Francesca Frigerio, Stephanie Migrenne, Juliette Martin-Levilain, Dorte M. Skytt, Kamilla Pajecka, Rafael Martin-del-Rio, Rolf Gruetter, Jorge Tamarit-Rodriguez, Helle S. Waagepetersen, Christophe Magnan, Pierre Maechler   +11 more
doaj   +1 more source

Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

Biology, 2017
The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake.
Leif Hertz, Douglas L Rothman
doaj   +1 more source

Suppressive effect of Yokukansan on glutamate released from canine keratinocytes

Open Veterinary Journal
Background: Canine atopic dermatitis (CAD) is caused by skin barrier dysfunction due to allergen exposure. Excessive glutamate release in the skin is associated with delayed skin barrier function recovery and epidermal thickening and lichenification ...
Yoichiro Kasuga, Ailing Hu, Zenji Kawakami, Masahiro Tabuchi, Takuji Yamaguchi, Hiroyuki Kobayashi, Shigaku Ikeda   +6 more
doaj   +1 more source

Molecular characterization of the Iranian isolates of Giardia lamblia: application of the glutamate dehydrogenase gene [PDF]

Iranian Journal of Public Health, 2008
Background: This study was conducted to determine of molecular epidemiology of the Giardia lamblia by PCR-RFLP method in Tehran, capital of Iran. Methods: Thirty eight stool samples were randomly selected from 125 patients diagnosed with giardiasis ...
Z Babaei, H Oormazdi, L Akhlaghi, S Rezaie, E Razmjou, SK Soltani- Arabshahi, AR Meamar, R Hadighi   +7 more
doaj   +1 more source

Blood AST, ALT and UREA/BUN Level Analysis

Bio-Protocol, 2013
AST (aspartate aminotransferase; GOT, glutamate oxalacetate transaminase) and ALT (alanine aminotransferase; GPT, glutamate pyruvate transaminase) are sensitive indicators to monitor the liver function under drugs treatment or with acute viral hepatitis.
Yuh-Pyng Sher, Mien-Chie Hung
doaj   +1 more source

Bioinformatics analysis identifies GLUD1 as a prognostic indicator for clear cell renal cell carcinoma

European Journal of Medical Research
Background Renal cell carcinoma (RCC) is a common primary tumor of the kidney and is divided into three major subtypes, of which clear cell renal cell carcinoma (ccRCC) has the highest incidence.
Shuang Liu
doaj   +1 more source