Molecular evolution of glutamate receptors: a primitive signaling mechanism that existed before plants and animals diverged [PDF]
Joanna C. Chiu+4 more
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The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding+19 more
wiley +1 more source
Polyploidy-mediated variations in glutamate receptor proteins linked to Fusarium wilt resistance in upland cotton. [PDF]
Parris S+18 more
europepmc +1 more source
Metabotropic glutamate receptors trigger postsynaptic protein synthesis.
Ivan Jeanne Weiler, William T. Greenough
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Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1 [PDF]
RW Gereau, P. Jeffrey Conn
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Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury
Traumatic brain injury (TBI) disrupts the blood–brain barrier and activates neuroimmune responses, causing metabolic disturbances and long‐term bone mass loss. Concurrent fractures accelerate healing and enhance osteogenesis but disrupt regulatory mechanisms, leading to altered bone dynamics and exacerbating neuroinflammation, complicating recovery ...
Wei Zhang, Jun Zou, Lingli Zhang
wiley +1 more source
Wolbachia-mediated reduction in the glutamate receptor mGluR promotes female promiscuity and bacterial spread. [PDF]
Warecki B+5 more
europepmc +1 more source
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 [PDF]
C. Joly+5 more
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STING COPII ER Export Trafficking and Signaling Primed by Phosphorylation Switches
This schematic outlines STING trafficking and signaling via coat protein II (COPII)‐mediated endoplasmic reticulum (ER) export. Following cyclic GMP‐AMP (cGAMP) stimulation, TANK‐binding kinase 1 (TBK1) activates on COPII vesicles, partially dissociating into the cytosol to phosphorylate ER‐localized STING, creating pSGME/pFS COPII‐sorting motifs ...
Yanan Nan+10 more
wiley +1 more source
Metabotropic Glutamate Receptor 5: A Potential Target for Neuropathic Pain Treatment. [PDF]
Manengu C+9 more
europepmc +1 more source