Results 191 to 200 of about 396,749 (354)

Correlative Imaging Platform Linking Taste Cell Function to Molecular Identity

Advanced Science, EarlyView.
A correlative imaging platform is developed to study how individual taste cells respond to different taste qualities. By linking cellular activity with molecular identity and environmental context, dual‐tuned taste cells capable of detecting both sweet and umami stimuli are identified.
Sungho Lee, Minjae Kim, Gha Yeon Park, Jubeen Yoon, Kunyoo Shin, Chang Ho Sohn, Myunghwan Choi   +6 more
wiley   +1 more source

Radiosynthesis and evaluation of an ¹⁸F-labeled radioligand for imaging metabotropic glutamate receptor 3 with positron emission tomography. [PDF]

Am J Nucl Med Mol Imaging
Rong J, Zhao C, Chaudhary AF, Chen J, Li Y, Zhou X, Song Z, Sun Z, Gao Y, Feng S, Zhao T, Hu QL, Li C, Haider A, Patel J, Ran C, Yuan H, Liang SH.   +17 more
europepmc   +1 more source

REEP1 Accumulation Disrupts ER Integrity and Drives Spinal Motoneuron Degeneration in Distal Hereditary Motor Neuropathy

Advanced Science, EarlyView.
REEP1 contributes to endoplasmic reticulum (ER) shaping. Variants either cause cortical motoneuron degeneration and hereditary spastic paraplegia (HSP) or spinal motoneuron degeneration and distal hereditary motor neuropathy (dHMN). Knockout causes less complex ER structures and cortical motoneuron loss.
Andrea Bock, Mona Schurig, Miles Willoughby, Andrea Mirecki, Eric Seemann, Kateryna Lohachova, Istvan Katona, Sonnhild Mittag, Lutz Liebmann, Patricia Franzka, Mehdi Heidari Horestani, Mukhran Khundadze, Thorsten Mosler, Timothy Louie, Marianne de Visser, Marian A. J. Weterman, Michael Kiehntopf, Christian Beetz, Sandor Nietzsche, Otmar Huber, Joachim Weis, Michael M. Kessels, Ramachandra M. Bhaskara, Britta Qualmann, Ivan Đikić, Christian A. Hübner   +25 more
wiley   +1 more source

Coordinated actions of NLR-assembled and glutamate receptor-like calcium channels in plant effector-triggered immunity. [PDF]

Proc Natl Acad Sci U S A
Wang J, Sun X, Xiong F, Lapin D, Lee T, Martin-Ramirez S, Prakken A, Shen Q, Bautor J, Maekawa T, Parker JE.   +10 more
europepmc   +1 more source

Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors [PDF]

, 2018
Francesco Matrisciano, Erbo Dong, Ferdinando Nicoletti, Alessandro Guidotti   +3 more
openalex   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, EarlyView.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

Clinical spectrum and outcomes of anti-metabotropic glutamate receptor 5 encephalitis in Chinese patients: a case report and literature review. [PDF]

Front Immunol
Niu Z, Chen S, Wang J, Yu M, Ren J, Liu R, Guo J, Zhang N, Gao F, Hao H.   +9 more
europepmc   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Effects of all-trans retinoic acid on glutamate receptor expression and dendritic spine density in the hypothalamus of rats. [PDF]

Front Neurosci
Kai YZ, Xia C, Shan QH, Tang ZQ.
europepmc   +1 more source

Disruption of Interdomain Interactions in the Glutamate Binding Pocket Affects Differentially Agonist Affinity and Efficacy of N-methyl-d-aspartate Receptor Activation [PDF]

, 2006
Wolfgang Maier, Rudolf Schemm, Christof Grewer, Bodo Laube   +3 more
openalex   +1 more source