Results 271 to 280 of about 396,749 (354)

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Effectiveness of positive allosteric modulators of metabotropic glutamate receptor 2/3 (mGluR2/3) in animal models of schizophrenia. [PDF]

Transl Psychiatry
Olivares-Berjaga D, Martínez-Pinteño A, Rodríguez N, Mas S, Morén C, Parellada E, Gassó P.   +6 more
europepmc   +1 more source

HLA‐DQA1*01:02 is associated with antibody multi‐reactivity with citrulline‐containing type II collagen epitopes while HLA‐DRB1*04:01 is associated with more private antibody reactivity with citrulline‐containing IgG epitopes in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Anti‐citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among RA patients, including for motif‐containing epitopes in important self‐antigens like collagen ...
S. Janna Bashar, Courtney B. Myhr, Adam H. Titi, Zihao Zheng, Miriam A. Shelef   +4 more
wiley   +1 more source

Exploring the activation mechanism of metabotropic glutamate receptor 2. [PDF]

Proc Natl Acad Sci U S A
Zhu X, Luo M, An K, Shi D, Hou T, Warshel A, Bai C.   +6 more
europepmc   +1 more source

Specific Association Patterns Between Brain Glutathione Levels, Myelination, and Functional Connectivity in Adults With Autism Spectrum Disorder

Autism Research, EarlyView.
ABSTRACT Recent studies have implicated oxidative stress in the pathophysiology of autism spectrum disorder (ASD). Postmortem brain studies have revealed decreased levels of the reduced form of glutathione (GSH), an important antioxidant, in some brain regions in individuals with ASD; however, in vivo evidence is lacking.
Toshiki Iwabuchi, Takaharu Hirai, Naoko Umeda, Hideto Yogo, Yuuta Nishimiya, Yuuki Nishigaki, Masaru Watanabe, Hidenori Yamasue, Masatsugu Tsujii, Kenji J. Tsuchiya, Hideo Matsuzaki   +10 more
wiley   +1 more source

Discovery of Thieno[3,2-<i>b</i>]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5. [PDF]

ACS Med Chem Lett
Crocker KE, Henderson SH, Capstick RA, Whomble DL, Bender AM, Felts AS, Han C, Engers JL, Billard NB, Maurer MA, Cho HP, Rodriguez AL, Niswender CM, O'Neill J, Watson KJ, Chang S, Blobaum AL, Boutaud O, Peng W, Rook JM, Conn PJ, Lindsley CW, Temple KJ.   +22 more
europepmc   +1 more source

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

A Scoping Review of Corticosterone-Induced Changes in Ionotropic Glutamate Receptor Levels and Localization in the Rodent Brain: Implications for the Auditory System. [PDF]

Brain Sci
Edlund E, Domarecka E, Olze H, Szczepek A.   +3 more
europepmc   +1 more source

Production and Formulation of Alcanivorax borkumensis SK2 Cell Powders for Marine Oil Spill Bioremediation

Biotechnology and Applied Biochemistry, EarlyView.
Abstract Oil spills pose severe threats to marine ecosystems and coastal communities. Alcanivorax borkumensis SK2, a marine bacterium with superior hydrocarbon‐degrading capabilities, emerges as a promising agent for bioremediation. This study identified an economical growth substrate for A.
Élisabeth Perreault, Denis Groleau, Patrick Vermette   +2 more
wiley   +1 more source

Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy <i>via</i> activation of the AMPK signaling pathway. [PDF]

World J Gastroenterol
Tao M, Zhang LL, Zhou GH, Wang C, Luo X.
europepmc   +1 more source