Results 31 to 40 of about 2,689,802 (421)

Effect of glutamate antagonists on nitric oxide production in rat brain following intrahippocampal injection [PDF]

Archives of Biological Sciences, 2007
Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. The involvement of ionotropic glutamate NMDA and AMPA/kainate receptors in induction of NO production in the rat brain was ...
Radenović Lidija, Selaković Vesna, Janać Branka, Todorović Dajana   +3 more
doaj   +1 more source

Ionotropic GABA and Glutamate Receptor Mutations and Human Neurologic Diseases

Molecular Pharmacology, 2015
The advent of whole exome/genome sequencing and the technology-driven reduction in the cost of next-generation sequencing as well as the introduction of diagnostic-targeted sequencing chips have resulted in an unprecedented volume of data directly ...
Hongjie Yuan, C. Low, Olivia A. Moody, A. Jenkins, S. Traynelis   +4 more
semanticscholar   +1 more source

Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction

Biomolecules, 2022
Glutamate excitotoxicity contributes to many neurodegenerative diseases. Excessive glutamate receptor-mediated calcium entry causes delayed calcium deregulation (DCD) that coincides with abrupt mitochondrial depolarization.
Brian M. Polster, Karla A. Mark, Rafael Arze, Derek Hudson   +3 more
doaj   +1 more source

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Science, 2014
Completing the Set G protein–coupled receptors (GPCRs) are membrane proteins that transduce extracellular signals to activate diverse signaling pathways. Significant insight into GPCR function has come from structures of three of four classes of GPCRs—A,
Huixian Wu, Chong Wang, K. Gregory, K. Gregory, G. Han, Hyekyung P. Cho, Yao Xia, C. Niswender, V. Katritch, J. Meiler, V. Cherezov, P. Conn, R. Stevens   +12 more
semanticscholar   +1 more source

Glutamate Receptors in Plants [PDF]

Annals of Botany, 2002
Ionotropic glutamate receptors function in animals as glutamate-gated non-selective cation channels. Numerous glutamate receptor-like (GLR) genes have been identified in plant genomes, and plant GLRs are predicted, on the basis of sequence homology, to retain ligand-binding and ion channel activity. Non-selective cation channels are ubiquitous in plant
openaire   +3 more sources

Binding of glutamate to the umami receptor [PDF]

Biophysical Chemistry, 2010
The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. It detects glutamate in humans, and is a more general amino acid detector in other species. We have constructed homology models of the ligand binding domains of the human umami receptor (based on crystallographic structures of the ...
Lopez Cacales, J., Oliviera Costa, S., de Groot, B., Walters, D.   +3 more
openaire   +6 more sources

Phased Treatment Strategies for Cerebral Ischemia Based on Glutamate Receptors

Frontiers in Cellular Neuroscience, 2019
Extracellular glutamate accumulation following cerebral ischemia leads to overactivation of glutamate receptors, thereby resulting in intracellular Ca2+ overload and excitotoxic neuronal injury. Multiple attempts have been made to counteract such effects
Yongjun Sun, Yongjun Sun, Xue Feng, Yue Ding, Mengting Li, Jun Yao, Long Wang, Zibin Gao, Zibin Gao   +8 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Synergistic inhibition of survival, proliferation, and migration of U87 cells with a combination of LY341495 and Iressa. [PDF]

PLoS ONE, 2013
Glioblastomas exploit various molecular pathways to promote glutamate- dependent growth by activating the AMPA (2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid) receptor, the group II metabotropic glutamate receptor, mGluR, and the epidermal ...
Zarina Yelskaya, Vangie Carrillo, Ewa Dubisz, Hira Gulzar, Devon Morgan, Shahana S Mahajan   +5 more
doaj   +1 more source