Results 61 to 70 of about 383,376 (207)

Functional Interactions of Alcohol-sensitive Sites in the \u3cem\u3eN\u3c/em\u3e-Methyl-d-aspartate Receptor M3 and M4 Domains [PDF]

, 2008
The N-methyl-d-aspartate receptor is an important mediator of the behavioral effects of ethanol in the central nervous system. Previous studies have demonstrated sites in the third and fourth membrane-associated (M) domains of the N-methyl-d-aspartate ...
Dwyer, Donard S., Lamb, Kaitlin A., Paul, Jaclyn M., Peoples, Robert W., Ren, Hong, Salous, Abdelghaffar K.   +5 more
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Intersubunit Interactions at Putative Sites of Ethanol Action in the M3 and M4 Domains of the NMDA Receptor GluN1 and GluN2B Subunits [PDF]

, 2016
Background and Purpose: The N-methyl-D-aspartate (NMDA) receptor is an important target of alcohol action in the brain. Recent studies in this laboratory have demonstrated that alcohol-sensitive positions in the intersubunit interfaces of the M3 and M4 ...
Alexander, Banke, Blanke, Boyce-Rustay, Chandrasekar, Chang, Chazot, Curtis, Dopico, Erreger, Gass, Gogas, Holmes, Honse, Jones, Karakas, Kash, Kash, Kash, Koob, Krystal, Krystal, Laha, Lee, Lima-Landman, Lovinger, Low, Low, Moykkynen, Moykkynen, Nagy, Pawson, Peoples, Ren, Ren, Ren, Ren, Ren, Ren, Ronald, Ryan, Schorge, Smothers, Sobolevsky, Sobolevsky, Sobolevsky, Venkatachalan, Wang, Wills, Woodward, Wright, Xu, Yuan, Zhao, Zheng   +54 more
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Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells

BMC Musculoskeletal Disorders, 2017
Background A body of evidence demonstrating changes to the glutaminergic system in tendinopathy has recently emerged. This hypothesis was further tested by studying the effects of glutamate on the tenocyte phenotype, and the impact of loading and ...
Christoph Spang, Ludvig J. Backman, Sandrine Le Roux, Jialin Chen, Patrik Danielson   +4 more
doaj   +1 more source

Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons [PDF]

, 2009
Burst firing of substantia nigra dopamine (SN DA) neurons is believed to represent an important teaching signal that instructs synaptic plasticity and associative learning.
Atherton, J.F., Bevan, M.D., Blythe, S.N., Wokosin, D.   +3 more
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Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration

Life, 2022
Glutamate neurotransmission and metabolism are finely modulated by the retinal network, where the efficient processing of visual information is shaped by the differential distribution and composition of glutamate receptors and transporters.
Isabella Boccuni, Richard Fairless
doaj   +1 more source

New Perspectives in the Studies on Endocannabinoid and Cannabis: Abnormal Behaviors Associate With CB1 Cannabinoid Receptor and Development of Therapeutic Application

Journal of Pharmacological Sciences, 2004
Δ9-Tetrahydrocannabinol (Δ9-THC), the major psychoactive component of marijuana, induces catalepsy-like immobilization and impairment of spatial memory in rats. Δ9-THC also induces aggressive behavior in isolated housing stress.
Michihiro Fujiwara, Nobuaki Egashira
doaj   +1 more source

Electrophysiological studies of Nephila clavata venom and toxin influence on hippocampal neuronal membranes after pretreatment with Aspergillus oryzae proteases

Біологічні студії, 2020
Background. The use of Arthropodae toxins for electrophysiological experiments is very important, but experimental data in this regard are scarce. The aim of this study was to obtain experimental data about the influence of Nephila clavata spider venom ...
O. M. Klyuchko
doaj   +1 more source

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders [PDF]

, 2013
Understanding the neurochemical basis for cognitive function is one of the major goals of neuroscience, with a potential impact on the diagnosis, prevention and treatment of a range of psychiatric and neurological disorders.
Akagbosu, Akladios, Alexander, Alkondon, Alkondon, Alkondon, Amori, Andersen, Atlas, Autier, Backman, Beal, Benatti, Bonda, Breese, Carpenedo, Carpenedo, Casazza, Castellano, Ceresoli-Borroni, Cesura, Chess, Chess, Chess, Chiarugi, Chiarugi, Clark, Cochran, Cozzi, Cui, Daily, Dalley, Dantzer, Darlington, Darlington, Davidson, Deiana, Della Torre, DiNatale, Dobelis, Dounay, Eastman, Erhardt, Forrest, Forrest, Forrest, Forrest, Fukui, Gellert, Giordani, Giorgini, Gold, Graef, Guidetti, Guidetti, Guidetti, Guidetti, Guillemin, Guillemin, Hardingham, Hedges, Henderson, Heng, Hernandez, Heyes, Hilmas, Holtze, Jason, Jauch, Jentsch, Jurgens, Kalisch, Kandanearatchi, Kiank, Kihara, Kloet, Kocki, Konradsson-Geuken, Lawrence, Lawrence, Linderholm, Lindsley, Luchowski, Luchowski, Lupien, Marin, Mexal, Millan, Miller, Minzenberg, Miura, Moeller, Mok, Muchowski, Muchowski, Mueller, Muscatell, Myint, Nagy, Neill, Newcomer, Newcomer, Nilsson, Nilsson, Nozaki, O'Connor, Olsson, Onur, Owe-Young, Paterson, Pearson, Pechtel, Pellicciari, Pellicciari, Perkins, Pertovaara, Pevarello, Phillips, Pocivavsek, Pocivavsek, Popoli, Popoli, Potter, Rahman, Raison, Rassoulpour, Ren, Robert, Rodgers, Rossi, Ryu, Röver, Saito, Salazar, Sapko, Sarter, Sathyasaikumar, Sathyasaikumar, Schwarcz, Schwarcz, Schwarcz, Schwarcz, Shear, Speciale, Speciale, Stazka, Stazka, Stone, Stone, Stone, Stone, Stone, Stoy, Tadaiesky, Tatter, Teichberg, Teichberg, Ting, Trecartin, Tse, Varasi, Vezzani, Walker, Wang, Wang, Wejksza, Wejksza, Wonodi, Xu, Yamada, Yuen, Zisapel, Zmarowski   +172 more
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High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

Neurobiology of Disease, 2013
Glutamate excitotoxicity is a consolidated hypothesis in neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor mediated effects.
Vincent Jean Henry, Maryline Lecointre, Vincent Laudenbach, Carine Ali, Richard Macrez, Amandine Jullienne, Vincent Berezowski, Peter Carmeliet, Denis Vivien, Stéphane Marret, Bruno José Gonzalez, Philippe Leroux   +11 more
doaj   +1 more source

Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression. [PDF]

, 2011
Several studies have proposed that brain glutamate signaling abnormalities and glial pathology have a role in the etiology of major depressive disorder (MDD).
Akil, H, Barchas, JD, Bernard, R, Bunney, WE, Jones, EG, Kerman, IA, Myers, RM, Schatzberg, AF, Thompson, RC, Watson, SJ   +9 more
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