Results 91 to 100 of about 2,660,183 (402)

Carbon‐Based Flexible Electrode for Efficient Electrochemical Generation of Reactive Chlorine Species in Tumor Therapy

Advanced Healthcare Materials, EarlyView.
A flexible electrode loaded with a carbon nanowire network (CC@C‐NWN) is developed for electrochemically generating reactive chlorine species (RCS) from abundant chloride ions in body fluids for tumor therapy. CC@C‐NWN enhances chlorine evolution, inducing redox dysregulation and synergistic apoptosis‐ferroptosis in tumor cells.
Cuinan Jiang, Zhaoyu Chen, Ruihao Yang, Ziga Luogu, Qian Ren, Hao Hu, Kaixin Wang, Senlin Li, Changlin Deng, Meng Li, Lu Zheng   +10 more
wiley   +1 more source

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Neurobiology of Disease, 1999
Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez, Carlos Matute   +1 more
doaj  

Glutamate Receptor Signaling in Retina Müller Cells: Plausible Role in Neurodegeneration

Receptors
The retinal network relies on glutamate, the primary excitatory neurotransmitter involved in the visual cycle. Glutamate transactions are carried out by an array of distinct receptors and transporters distributed across both pre- and post-synaptic ...
Bolaji Oyetayo, Yurixy Mendoza-Silva, Temitayo Subair, Luisa C Hernández-Kelly, Marie-Paule Felder-Schmittbuhl, Tatiana N. Olivares-Bañuelos, Arturo Ortega   +6 more
doaj   +1 more source

CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken

Brazilian Journal of Poultry Science, 2019
Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited.
F Ahmadi, M Zendehdel, V Babapour, N Panahi   +3 more
doaj   +1 more source

THE POSSIBILITY OF ADMINISTRATION OF GLUTAMATE RECEPTORS ANTAGONISTS IN THE TREATMENT OF PARKINSON'S DISEASE [PDF]

Research Results in Pharmacology, 2016
Parkinson's disease is the slow-progressing chronic neurodegenerative disease. It caused by the progressive destruction and death of neurons that produce the neurotransmitter dopamine, primarily in the substantia nigra and also in other parts of the ...
Natalya Avdeeva, Vladislava Nikitina, Indira Kochkarova, Anna Litvinova   +3 more
doaj   +3 more sources

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Biomimetic Scaffolds Enhance iPSC Astrocyte Progenitor Angiogenic, Immunomodulatory, and Neurotrophic Capacity in a Stiffness and Matrix‐Dependent Manner for Spinal Cord Repair Applications

Advanced Healthcare Materials, EarlyView.
Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor, Ian Woods, Sarah F. McComish, Sean Kerr, Matthew McGrath, Juan Carlos Palomeque Chávez, Jack Maughan, Tara McGuire, Maeve A. Caldwell, Adrian Dervan, Fergal J. O'Brien   +10 more
wiley   +1 more source

Transport of BMAA into Neurons and Astrocytes by System x\u3csub\u3ec\u3c/sub\u3e- [PDF]

, 2018
The study of the mechanism of β-N-methylamino-l-alanine (BMAA) neurotoxicity originally focused on its effects at the N-methyl-d-aspartate (NMDA) receptor. In recent years, it has become clear that its mechanism of action is more complicated.
Albano, Rebecca, Lobner, Doug
core   +1 more source

The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]

, 2010
The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Beierlein, Bellamy, Boison, Bordey, Boris P. Klyuch, Brasnjo, Clark, Craig, Dale, Dale, Dale, Daniel, Delaney, Edwards, Fredholm, Fredholm, Isope, Jo, Kimura, Li, Llaudet, Llaudet, Magnus J. E. Richardson, Mark J. Wall, Martín, Mitchell, Mitterdorfer, Nedergaard, Neher, Nicholas Dale, Pearson, Pearson, Piet, Richardson, Rossi, Sabatini, Sweeney, Tsodyks, Wall, Wall, Wall, Wong   +41 more
core   +2 more sources

Covalent Organic Frameworks for Photocatalysis

Advanced Materials, EarlyView.
This review provides an overview of recent advances in covalent organic frameworks (COFs) for photocatalysis, focusing on sustainable energy applications like water splitting, hydrogen peroxide generation, and CO2 and N2 reduction. It discusses design principles, structure‐function relationships, challenges in COF photocatalysis, and strategies to ...
Bikash Mishra, Akhtar Alam, Avanti Chakraborty, Bidhan Kumbhakar, Samrat Ghosh, Pradip Pachfule, Arne Thomas   +6 more
wiley   +1 more source