Results 101 to 110 of about 314,122 (297)

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

Frontiers in Molecular Neuroscience, 2019
Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve injury is long lasting and responsible for long-term disability in ...
Vanessa Pereira, Cyril Goudet
doaj   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Glutamate load fosters spreading depolarization under osmotic stress in brain slices

Frontiers in Cellular Neuroscience
IntroductionCerebral edema is a hallmark of lesion progression after acute ischemic stroke (AIS) and a major contributor to the evolution of spreading depolarizations (SDs). SDs trigger extracellular glutamate accumulation and excitotoxic injury, yet the
Rita Frank, Rita Frank, Stephane Marinesco, Ferenc Bari, Ákos Menyhárt, Ákos Menyhárt, Eszter Farkas, Eszter Farkas   +7 more
doaj   +1 more source

Dysfunctional Light-Evoked Regulation of cAMP in Photoreceptors and Abnormal Retinal Adaptation in Mice Lacking Dopamine D4 Receptors [PDF]

, 2002
Dopamine is a retinal neuromodulator that has been implicated in many aspects of retinal physiology. Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.
Grandy, David K., Haque, Rashidul, Harrison, Joseph M., Iuvone, P. Michael, Low, Malcolm J., Nir, Izhak, Rubinstein, Marcelo   +6 more
core   +1 more source

Synchrotron XRF Imaging Reveals Manganese Accumulation in the Golgi and Post‐Synapses of Neurons and Enhanced Uptake in Astrocytes

Advanced Science, EarlyView.
Despite widespread exposure, the mechanisms of manganese neurotoxicity remain poorly understood. Using correlative cryogenic fluorescence and synchrotron X‐ray fluorescence imaging techniques, we show that the Golgi apparatus is the primary accumulation site for manganese in both neurons and astrocytes, and that manganese targets the neuronal ...
Ines Kelkoul, Aiyarin Kittilukkana, Luis C. C. Huarte, Hiram Castillo‐Michel, Murielle Salome, Stéphane Roudeau, Pauline Belzanne, Matthieu Sainlos, Noémie Pied, Monica Fernandez‐Monreal, Daniel Choquet, Richard Ortega, Asuncion Carmona   +12 more
wiley   +1 more source

Control of cortical neuronal migration by glutamate and GABA

Frontiers in Cellular Neuroscience, 2015
Neuronal migration in the cortex is controlled by the paracrine action of the classical neurotransmitters glutamate and GABA. Glutamate controls radial migration of pyramidal neurons by acting primarily on NMDA receptors and regulates tangential ...
Heiko J Luhmann, Werner eKilb, Atsuo eFukuda   +2 more
doaj   +1 more source

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses

, 2012
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP ...
A Araque, A Destexhe, AG Nikonenko, AL Hodgkin, AM Weber, AM Zhabotinsky, B Katz, B Mouillac, B Sahin, BL Bloodgood, BL Sabatini, BL Sabatini, C Agulhon, C Agulhon, C Fall, C Henneberger, C Koch, CLM Bon, D Dumitriu, D Sochivko, DJ Hagler Jr, DX Keller, E Neher, EB Malarkey, ER Higgins, F Erler, F Helmchen, F Taqatqeh, G Perea, GA Rameau, GL Collingridge, GW Young De, H-K Lee, HJ Koester, HV McCue, I Nikonenko, I Wenker, J Bai, J Boehm, J Garthwaite, J Kang, J Keener, J Lisman, J Marchaland, J Sneyd, J-W Shuai, JA Bibb, JE Lisman, JH Bollmann, JH Bollmann, JT Porter, Kaushik Majumdar, KD Micheva, KG Phillips, KM Franks, KT Blackwell, L-C Ching, L-Y Wang, LC Griffith, M Mazzanti, M Pittà De, M Tsodyks, MS Jafri, N Aslam, NC Danbolt, NJ Emptage, P Bezzi, P Miller, PP Atluri, R Anwyl, R Bertram, R Llinas, R Schneggenburger, R Schneggenburger, R Vargas, RA Hopper, RC Malenka, RF Fox, RP Munton, S Ben Achour, S Nadkarni, S Nadkarni, Shivendra Tewari, SJ Taylor, T Ishikawa, TA Fiacco, TP Jensen, TVP Bliss, TVP Bliss, V Calabrese, V Montana, V Parpura, V Parpura, V Volman, WT Coffey, Y Watanabe, Y-X Li, Z Nusser   +97 more
core   +1 more source

Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine [PDF]

, 2014
Peer reviewedPublisher ...
Anne-Sophie eDelbes, Celine eCansell, Francois eTronche, Frederic eAmbroggi, Frederic eAmbroggi, Jacques eBARIK, Jacques eBARIK, Marc eTuriault, Marie-Louise eDongelmans, Pier Vincenzo Piazza, Sebastien eParnaudeau, Sebastien eParnaudeau, Serge H Luquet   +12 more
core   +6 more sources

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source