Results 31 to 40 of about 2,596,775 (326)

Channel opening and gating mechanism in AMPA-subtype glutamate receptors

Nature, 2017
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system.
E. C. Twomey, M. Yelshanskaya, R. Grassucci, J. Frank, A. Sobolevsky   +4 more
semanticscholar   +1 more source

Structural Mechanisms of Gating in Ionotropic Glutamate Receptors

Biochemistry, 2017
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the central nervous system.
E. C. Twomey, A. Sobolevsky
semanticscholar   +1 more source

Epileptic syndrome in the clinical picture of the diseaseand the level of antibodies to GluR1 subunit of AMPA glutamate receptors in the patients with gliomas in the cerebral hemispheres of a brain

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013
The authors examined 92 patients with gliomas in the cerebral hemispheres. The immunoenzyme method was used for semiquantitative assay of the level of autoantibodies to GluR1 subunit of AMPA receptors of glutamate.
V. N. Ochkolyas, A. F. Gurchin, A. A. Skoromets, A. V. Kostyukevich   +3 more
doaj   +1 more source

Pathophysiological Ionotropic Glutamate Signalling in Neuroinflammatory Disease as a Therapeutic Target

Frontiers in Neuroscience, 2021
Glutamate signalling is an essential aspect of neuronal communication involving many different glutamate receptors, and underlies the processes of memory, learning and synaptic plasticity.
Richard Fairless, Richard Fairless, Hilmar Bading, Ricarda Diem, Ricarda Diem   +4 more
doaj   +1 more source

Astroglial Glutamate Signaling and Uptake in the Hippocampus

Frontiers in Molecular Neuroscience, 2018
Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond
Christine R. Rose, Lisa Felix, Andre Zeug, Dirk Dietrich, Andreas Reiner, Christian Henneberger, Christian Henneberger, Christian Henneberger   +7 more
doaj   +1 more source

Metabotropic glutamate receptor trafficking [PDF]

Molecular and Cellular Neuroscience, 2018
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh, Kai Chang, Katherine W. Roche   +2 more
openaire   +2 more sources

The DLGAP family: neuronal expression, function and role in brain disorders

Molecular Brain, 2017
The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft.
Andreas H. Rasmussen, Hanne B. Rasmussen, Asli Silahtaroglu   +2 more
doaj   +1 more source

Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

bioRxiv, 2016
Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection in insects, recent work has implicated two
Zachary A. Knecht, Ana F. Silbering, Lina Ni, M. Klein, Gonzalo Budelli, R. Bell, L. Abuin, Anggie J. Ferrer, Aravinthan D. T. Samuel, R. Benton, P. Garrity   +10 more
semanticscholar   +1 more source

Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors

Frontiers in Molecular Neuroscience, 2018
Glutamate receptors play a crucial role in the central nervous system and are implicated in different brain disorders. They play a significant role in the pathogenesis of neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease,
Md. Jakaria, Shin-Young Park, Md. Ezazul Haque, Govindarajan Karthivashan, In-Su Kim, Palanivel Ganesan, Palanivel Ganesan, Dong-Kug Choi, Dong-Kug Choi, Dong-Kug Choi   +9 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source