Results 41 to 50 of about 2,655,971 (425)

Roles of Glutamate Receptors in Parkinson’s Disease

International Journal of Molecular Sciences, 2019
Parkinson’s disease is a progressive neurodegenerative disorder resulting from the degeneration of pigmented dopaminergic neurons in the substantia nigra pars compacta. It induces a series of functional modifications in the circuitry of the basal ganglia
Zhu Zhang, Shiqing Zhang, Pengfei Fu, Zhang Zhang, Kaili Lin, J. Ko, K. Yung   +6 more
semanticscholar   +1 more source

Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels

Pharmacological Reviews, 2021
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian central nervous system, are mediated via signaling by ionotropic glutamate receptors (iGluRs).
K. Hansen, L. Wollmuth, D. Bowie, Hiro Furukawa, F. Menniti, A. Sobolevsky, G. Swanson, Sharon A. Swanger, I. Greger, T. Nakagawa, C. McBain, V. Jayaraman, C. Low, M. Dell’Acqua, J. Diamond, Chad R. Camp, Riley E. Perszyk, Hongjie Yuan, S. Traynelis   +18 more
semanticscholar   +1 more source

Metabotropic glutamate receptors in cancer [PDF]

Neuropharmacology, 2017
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen, Brian A. Wall, Janet Wangari-Talbot, Lumeng J. Yu   +3 more
openaire   +3 more sources

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +1 more source

Astrocyte Glutamate Uptake and Signaling as Novel Targets for Antiepileptogenic Therapy

Frontiers in Neurology, 2020
Astrocytes regulate and respond to extracellular glutamate levels in the central nervous system (CNS) via the Na+-dependent glutamate transporters glutamate transporter-1 (GLT-1) and glutamate aspartate transporter (GLAST) and the metabotropic glutamate ...
Allison R. Peterson, Devin K. Binder
doaj   +1 more source

Modulation of glutamate transport and receptor binding by glutamate receptor antagonists in EAE rat brain. [PDF]

PLoS ONE, 2014
The etiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The elevation of glutamate in cerebrospinal fluid, as well as changes in the expression of glutamate receptors ...
Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Elżbieta Salińska, Lidia Strużyńska   +3 more
doaj   +1 more source

Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]

EMBO J 22, 18 (15/09/2003) 4656-65, 2007
Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv   +1 more source

Glutamate receptor pores [PDF]

The Journal of Physiology, 2014
AbstractGlutamate receptors are ligand‐gated ion channels that mediate fast excitatory synaptic transmission throughout the central nervous system. Functional receptors are homo‐ or heteromeric tetramers with each subunit contributing a re‐entrant pore loop that dips into the membrane from the cytoplasmic side. The pore loops form a narrow constriction
openaire   +3 more sources

Posttranslational Modification Biology of Glutamate Receptors and Drug Addiction

Frontiers in Neuroanatomy, 2011
Posttranslational covalent modifications of glutamate receptors remain a hot topic. Early studies have established that this family of receptors, including almost all ionotropic and metabotropic glutamate receptor subtypes, undergoes active ...
Li-Min eMao, Ming-Lei eGuo, Dao-Zhong eJin, Eugene E Fibuch, Eun Sang eChoe, John Q Wang   +5 more
doaj   +1 more source

Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]

, 2016
NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E, Lopez, Melany N, Wilding, Timothy J   +2 more
core   +2 more sources