Results 51 to 60 of about 2,655,971 (425)
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Nature, 2017 AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission throughout the central nervous system.
E. C. Twomey +4 more
semanticscholar +1 more source
bioRxiv, 2016 Ionotropic Receptors (IRs) are a large subfamily of variant ionotropic glutamate receptors present across Protostomia. While these receptors are most extensively studied for their roles in chemosensory detection in insects, recent work has implicated two
Zachary A. Knecht +10 more
semanticscholar +1 more source
Energetics of Glutamate Binding to an Ionotropic Glutamate Receptor [PDF]
The Journal of Physical Chemistry B, 2017 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that are responsible for the majority of excitatory transmission at the synaptic cleft. Mechanically speaking, agonist binding to the ligand binding domain (LBD) activates the receptor by triggering a conformational change that is transmitted to the transmembrane region, opening the ...
Alvin Yu +3 more
openaire +5 more sources
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]
, 2017 Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y +12 more
core +1 more source
Structural Mechanisms of Gating in Ionotropic Glutamate Receptors
Biochemistry, 2017 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory neurotransmission in the central nervous system.
E. C. Twomey, A. Sobolevsky
semanticscholar +1 more source
Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]
, 2003 The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Colquhoun, D., Schorge, S.
core +1 more source
Binding of glutamate to the umami receptor [PDF]
Biophysical Chemistry, 2010 The umami taste receptor is a heterodimer composed of two members of the T1R taste receptor family: T1R1 and T1R3. It detects glutamate in humans, and is a more general amino acid detector in other species. We have constructed homology models of the ligand binding domains of the human umami receptor (based on crystallographic structures of the ...
Lopez Cacales, J. +3 more
openaire +5 more sources
Astroglial Glutamate Signaling and Uptake in the Hippocampus
Frontiers in Molecular Neuroscience, 2018 Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to active signaling and information processing in the brain. Contrary to this classical view, it is now firmly established that astrocytes can specifically respond
Christine R. Rose +7 more
doaj +1 more source
Frontiers in Neuroscience, 2021 Glutamate signalling is an essential aspect of neuronal communication involving many different glutamate receptors, and underlies the processes of memory, learning and synaptic plasticity.
Richard Fairless +4 more
doaj +1 more source