Results 1 to 10 of about 2,024,212 (329)

Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters

Neurobiology of Disease, 2009
Glutamate excitotoxicity has been implicated in the neuropathology of Huntington's disease (HD), due to the toxicity of glutamate receptor agonists on striatal medium spiny neurons (MSN), the most affected neuronal population in HD.
Ana María Estrada-Sánchez, Teresa Montiel, José Segovia, Lourdes Massieu   +3 more
doaj   +1 more source

Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions

Cells, 2022
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases.
Viswanthram Palanivel, Vivek Gupta, Seyed Shahab Oddin Mirshahvaladi, Samridhi Sharma, Veer Gupta, Nitin Chitranshi, Mehdi Mirzaei, Stuart L Graham, Devaraj Basavarajappa   +8 more
doaj   +1 more source

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]

, 2011
Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey, Asrari, Barthel, Bègue-Kirn, Cabrera, Camargo, Doug Lobner, Duailibi, D’Souza, Fogal, Franco, Furey, Goldberg, Gronthos, Hansen, Hu, Kalyva, Katherine Pauly, Kaur, Keelan, Kim, Kim, Kymberly Fritz, Lobner, Lovschall, Marcato, Nie, Onishi, Pacheco, Paranjpe, Piani, Piattelli, Ricketts, Rutherford, Stanley, Stockton, Tziafas, Tziafas, Ward, Wood   +39 more
core   +2 more sources

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source

Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway

Neurobiology of Disease, 2008
The neurotransmitter glutamate mediates excitatory synaptic transmission in the brain and spinal cord. In pathological conditions massive glutamate release reaches near millimolar concentrations in the extracellular space and contributes to neuron ...
Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Kay L. Saving, Meena Gujrati, Dan Fassett, Jeffrey D. Klopfenstein, Dzung H. Dinh, Jasti S. Rao   +7 more
doaj   +1 more source

Role of Aβ in Alzheimer’s-related synaptic dysfunction

Frontiers in Cell and Developmental Biology, 2022
Synaptic dysfunction is closely related to Alzheimer’s disease (AD) which is also recognized as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which disrupts synaptic plasticity and mediates the synaptic toxicity through ...
Huiqin Zhang, Xuefan Jiang, Lina Ma, Wei Wei, Zehui Li, Surui Chang, Jiayu Wen, Jiahui Sun, Hao Li, Hao Li   +9 more
doaj   +1 more source

Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. [PDF]

, 2014
BackgroundIn dementia with Lewy bodies (DLB) abnormal interactions between α-synuclein (α-syn) and beta amyloid (Aβ) result in selective degeneration of neurons in the neocortex, limbic system and striatum.
Cartier, Anna, Desplats, Paula, Masliah, Eliezer, Overk, Cassia R, Patrick, Christina, Price, Diana L, Rockenstein, Edward, Shaked, Gideon, Spencer, Brian, Ubhi, Kiren   +9 more
core   +3 more sources

Pre- and postnatal exposure to moderate levels of ethanol can have long-lasting effects on hippocampal glutamate uptake in adolescent offspring. [PDF]

PLoS ONE, 2015
The developing brain is vulnerable to the effects of ethanol. Glutamate is the main mediator of excitatory signals in the brain and is probably involved in most aspects of normal brain function during development. The aim of this study was to investigate
Giovana Brolese, Paula Lunardi, Daniela F de Souza, Fernanda M Lopes, Marina C Leite, Carlos-Alberto Gonçalves   +5 more
doaj   +1 more source

Kaempferia parviflora Rhizome Extract Inhibits Glutamate-Induced Toxicity in HT-22 Mouse Hippocampal Neuronal Cells and Extends Longevity in Caenorhabditis elegans

Biology, 2021
Kaempferia parviflora Wall. ex Baker (KP) or “Kra-chai-dam” has been shown to exhibit several pharmacological effects including anti-inflammation, antimicrobial, and sexual-enhancing activity. The objectives of this study included an investigation of the
Aunchalee Tonsomboon, Mani Iyer Prasanth, Waluga Plaingam, Tewin Tencomnao   +3 more
doaj   +1 more source

Protective activity of aromatic amines and imines against oxidative nerve cell death [PDF]

, 2001
Oxidative stress is a widespread phenomenon in the pathology of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.
Behl, Christian, Beyer, Klaus, Moosmann, Bernd, Skutella, Thomas   +3 more
core   +1 more source