Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease [PDF]
Frontiers in Neuroscience, 2020 Parkinson’s disease (PD) is a common neurodegenerative disease, the pathological features of which include the presence of Lewy bodies and the neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta.
Ji Wang +10 more
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Astrocyte senescence promotes glutamate toxicity in cortical neurons. [PDF]
PLoS ONE, 2020 Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer's and related dementias and cancer patients after chemo- or radio-therapies.
Chandani Limbad +7 more
doaj +8 more sources
Potential Thai medicinal plants for neurodegenerative diseases: A review focusing on the anti-glutamate toxicity effect [PDF]
Journal of Traditional and Complementary Medicine, 2020 Neurodegenerative diseases (NDD) are a range of debilitating conditions of the brain involving progressive loss of neurons, many of which are still currently incurable despite enormous efforts on drug discovery and development in the past decade.
Anchalee Prasansuklab +2 more
doaj +3 more sources
Chronic glutamate toxicity in neurodegenerative diseases-what is the evidence? [PDF]
Frontiers in Neuroscience, 2015 Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain. Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate receptors) and a class of G-protein coupled receptors (metabotropic glutamate ...
Pamela eMaher, Jan eLewerenz
doaj +3 more sources
Natural products as safeguards against monosodium glutamate-induced toxicity [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory ...
Mahdi Hajhasani +4 more
doaj +4 more sources
In vivo evidence of glutamate toxicity in multiple sclerosis. [PDF]
Ann Neurol, 2014 ObjectiveThere is increasing evidence that altered glutamate (Glu) homeostasis is involved in the pathophysiology of multiple sclerosis (MS). The aim of this study was to evaluate the in vivo effects of excess brain Glu on neuroaxonal integrity measured by N‐acetylaspartate (NAA), brain volume, and clinical outcomes in a large, prospectively followed ...
Azevedo CJ +8 more
europepmc +8 more sources
Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2. [PDF]
ACS Chem Biol, 2021 The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer’s disease.
Rosarda JD +7 more
europepmc +2 more sources
Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity. [PDF]
Biomolecules, 2021 Oxidative stress is one of the main causes of brain cell death in neurological disorders. The use of natural antioxidants to maintain redox homeostasis contributes to alleviating neurodegeneration. Glutamate is an excitatory neurotransmitter that plays a
Trinh TA +4 more
europepmc +2 more sources
Pathological Interplay between Inflammation and Mitochondria Aggravates Glutamate Toxicity. [PDF]
Int J Mol SciMitochondrial dysfunction and glutamate toxicity are associated with neural disorders, including brain trauma. A review of the literature suggests that toxic and transmission actions of neuronal glutamate are spatially and functionally separated.
Vaglio-Garro A +3 more
europepmc +2 more sources
Mitochondrial Cyclosporine A-Independent Palmitate/Ca2+-Induced Permeability Transition Pore (PA-mPT Pore) and Its Role in Mitochondrial Function and Protection against Calcium Overload and Glutamate Toxicity [PDF]
Cells, 2021 A sharp increase in the permeability of the mitochondrial inner membrane known as mitochondrial permeability transition (or mPT) occurs in mitochondria under the conditions of Ca2+ and ROS stress.
Galina D. Mironova, Evgeny V. Pavlov
doaj +2 more sources