Comparative Study of the Protective and Neurotrophic Effects of Neuronal and Glial Progenitor Cells-Derived Conditioned Media in a Model of Glutamate Toxicity In Vitro [PDF]
Biomolecules, 2023 Cell therapy represents a promising approach to the treatment of neurological diseases, offering potential benefits not only by cell replacement but also through paracrine secretory activities. However, this approach includes a number of limiting factors,
Georgy Leonov +5 more
doaj +2 more sources
J Tradit Complement Med, 2020 Background Neurodegenerative diseases, such as Alzheimer’s disease, cause a great deal of suffering for both patients and carers. Bacopa monnieri (L.) wettst.
Brimson JM +3 more
europepmc +2 more sources
Interplay between Energy Supply and Glutamate Toxicity in the Primary Cortical Culture [PDF]
BiomoleculesLimited substrate availability because of the blood–brain barrier (BBB) has made the brain develop specific molecular mechanisms to survive, using lactate synthesized by astrocytes as a source of energy in neurons.
Annette Vaglio-Garro +6 more
doaj +2 more sources
Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway. [PDF]
Korean J Physiol Pharmacol, 2019 Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke.
Cui Y +8 more
europepmc +2 more sources
SLC38A10 Transporter Plays a Role in Cell Survival Under Oxidative Stress and Glutamate Toxicity [PDF]
Frontiers in Molecular Biosciences, 2021 Solute carrier (SLC) transporters regulate amino acids, glucose, ions, and metabolites that flow across cell membranes. In the brain, SLCs are the key regulators of neurotransmission, in particular, the glutamate/GABA-glutamine (GGG) cycle.
Rekha Tripathi +2 more
doaj +2 more sources
Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex [PDF]
Neurobiology of Disease, 2007 In addition to the loss of spinal motor neurons, amyotrophic lateral sclerosis (ALS) is also associated with degeneration of corticospinal layer V pyramidal neurons and decreased glutamate transport in the cortex. We characterized the glutamate receptors
Kate C. Young +2 more
doaj +3 more sources
KYNA Ameliorates Glutamate Toxicity of HAND by Enhancing Glutamate Uptake in A2 Astrocytes. [PDF]
Int J Mol SciReactive astrocytes are key players in HIV-associated neurocognitive disorders (HAND), and different types of reactive astrocytes play opposing roles in the neuropathologic progression of HAND. A recent study by our group found that gp120 mediates A1 astrocytes (neurotoxicity), which secrete proinflammatory factors and promote HAND disease progression.
Chen J +7 more
europepmc +3 more sources
Cell Journal, 2016 Objective: Chlorpyrifos (CPF) is a neurotoxic organophosphorus (OP) insecticide. Its mechanism of action includes oxidative stress, excitotoxicity, and inhibition of the acetylcholinesterase enzyme (AChE). The aim of the present study is to investigate
Nahid Amani +3 more
doaj +2 more sources
The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis. [PDF]
Cell Calcium, 2018 Maher P +5 more
europepmc +2 more sources
Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation. [PDF]
Cell Mol Neurobiol, 2019 Bao F, Tao L, Zhang H.
europepmc +2 more sources