Results 31 to 40 of about 2,024,212 (329)

Astrocyte/neuron ratio and its importance on glutamate toxicity: an in vitro voltammetric study. [PDF]

Cytotechnology, 2016
Hacimuftuoglu A, Tatar A, Cetin D, Taspinar N, Saruhan F, Okkay U, Turkez H, Unal D, Stephens RL, Suleyman H.   +9 more
europepmc   +2 more sources

Glutamate-Independent Calcium Toxicity [PDF]

Stroke, 2007
It is widely accepted that a critical factor in determining neuronal death during cerebral ischemia is the progressive accumulation of intracellular Na+ ([Na+]i) and Ca2+ ([Ca2+]i) ions, which can precipitate necrosis and apoptosis of vulnerable neurons.
ANNUNZIATO, LUCIO, CATALDI, MAURO, PIGNATARO, GIUSEPPE, SECONDO, AGNESE, MOLINARO, PASQUALE   +4 more
openaire   +4 more sources

Response of tyramine and glutamate related signals to nanoplastic exposure in Caenorhabditis elegans

Ecotoxicology and Environmental Safety, 2021
Neurotransmission related signals are involved in the control of response to toxicants. We here focused on the tyramine and the glutamate related signals to determine their roles in regulating nanoplastic toxicity in Caenorhabditis elegans.
Shuting Wang, Huanliang Liu, Man Qu, Dayong Wang   +3 more
doaj   +1 more source

Glutamate transmission and toxicity in alzheimer's disease [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1988
1. Despite intensive research, the cause of Alzheimer's disease is unknown. 2. Glutamate is the major excitatory transmitter of the cerebral cortex and hippocampus and it appears to have an important role in learning and memory. In addition to its transmitter function, glutamate is a neurotoxin which has been implicated in the pathogenesis of a variety
Greenamyre, J. Timothy, Maragos, William F., Albin, Roger L., Penney, John B., Young, Anne B.   +4 more
openaire   +3 more sources

Neuroprotective Effects of Extracts from Tiger Milk Mushroom Lignosus rhinocerus Against Glutamate-Induced Toxicity in HT22 Hippocampal Neuronal Cells and Neurodegenerative Diseases in Caenorhabditis elegans

Biology, 2021
Despite the Tiger Milk Mushroom Lignosus rhinocerus (LR) having been used as a traditional medicine, little is known about the neuroprotective effects of LR extracts.
Parinee Kittimongkolsuk, Nattaporn Pattarachotanant, Siriporn Chuchawankul, Michael Wink, Tewin Tencomnao   +4 more
doaj   +1 more source

Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage and Caenorhabditis elegans Lifespan/Healthspan Enhancing Activity of Auricularia polytricha Mushroom Extracts

Pharmaceuticals, 2021
Oxidative stress is associated with several diseases, particularly neurodegenerative diseases, commonly found in the elderly. The attenuation of oxidative status is one of the alternatives for neuroprotection and anti-aging.
Chanin Sillapachaiyaporn, Panthakarn Rangsinth, Sunita Nilkhet, Alison T. Ung, Siriporn Chuchawankul, Tewin Tencomnao   +5 more
doaj   +1 more source

Comparison of the protective effect of cytosolic and mitochondrial Peroxiredoxin 5 against glutamate-induced neuronal cell death

Redox Report, 2021
Objectives: Although glutamate is an essential factor in the neuronal system, excess glutamate can produce excitotoxicity. We previously reported that Peroxiredoxin 5 (Prx5) protects neuronal cells from glutamate toxicity via its antioxidant effects ...
Mi Hye Kim, Da Yeon Kim, Hong Jun Lee, Young-Ho Park, Jae-Won Huh, Dong-Seok Lee   +5 more
doaj   +1 more source

Vitis Vinifera Leaf Extract Protects Against Glutamate-Induced Oxidative Toxicity in HT22 Hippocampal Neuronal Cells and Increases Stress Resistance Properties in Caenorhabditis Elegans

Frontiers in Nutrition, 2021
Vitis vinifea has been used for traditional medicines, food, beverages, and dietary antioxidant supplements. The chemical compositions and biological activities of the fruits and seeds have been extensively investigated.
Chatrawee Duangjan, Chatrawee Duangjan, Chatrawee Duangjan, Panthakarn Rangsinth, Panthakarn Rangsinth, Shaoxiong Zhang, Shaoxiong Zhang, Xiaojie Gu, Xiaojie Gu, Michael Wink, Tewin Tencomnao, Tewin Tencomnao, Tewin Tencomnao   +12 more
doaj   +1 more source

Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway

Frontiers in Pharmacology, 2021
Purpose: It is revealed that Xiaoyaosan could reduce glutamate level in the hippocampus of depressed rats, whose metabolism leads to the pathophysiology of depression. However, the underlying mechanism remains unclear.
Xue-Ming Zhou, Chen-yue Liu, Yue-yun Liu, Qingyu Ma, Xin Zhao, You-ming Jiang, Xiao-Juan Li, Jia-xu Chen   +7 more
semanticscholar   +1 more source

Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate

Progress in Microbes and Molecular Biology, 2020
The increased concentration of extracellular glutamate has been reported to play a key role in most of the neurodegenerative diseases, such as Parkinson’s disease and Alzheimer’s disease, even though its importance as an amino acid neurotransmitter in ...
Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan   +2 more
doaj   +1 more source